List of works - Ignacio Moraga

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

scientific article published on 06 August 2019

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

scientific article published on 01 December 2020

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

scientific article published on 16 April 2010

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

scientific article published in March 2017

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

scientific article published on 15 September 2020

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

scientific article

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

scientific journal article

Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis

scientific article published on 31 March 2021

Insights into cytokine-receptor interactions from cytokine engineering

scientific article

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

scientific article

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

scientific article published on 27 November 2019

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells

scientific article published in May 2008

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

scientific article

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22:

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

scientific article published on 26 November 2019

Mapping Determinants of Cytokine Signaling via Protein Engineering

scientific article published on 27 September 2018

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

scientific article published on 07 February 2020

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

scientific article

Multifarious determinants of cytokine receptor signaling specificity.

scientific article published on January 2014

Receptor density is key to the alpha2/beta interferon differential activities.

scientific article published on 29 June 2009

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

scientific article

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

scientific article

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

scientific article published on 02 October 2007

SS2-3 A cross-talk between the Stat3/SOCS3 and the IRS-1/PI3K/p70S6K pathways regulates antiproliferative activity of IFNβ

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

scientific article

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

scientific article published in 2024

Superkines: cytokines displaying better targeted functions

scientific article published on 26 April 2013

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

scientific article

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

scientific article published on March 2017

The role of RPGR in cilia formation and actin stability

scientific article

Translational control as the basis of the differential antiproliferative potency of IFNα2 and IFNβ

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

scientific article published on 26 February 2015

List of works by Ignacio Moraga

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis

Insights into cytokine-receptor interactions from cytokine engineering

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22:

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Mapping Determinants of Cytokine Signaling via Protein Engineering

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Multifarious determinants of cytokine receptor signaling specificity.

Receptor density is key to the alpha2/beta interferon differential activities.

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

SS2-3 A cross-talk between the Stat3/SOCS3 and the IRS-1/PI3K/p70S6K pathways regulates antiproliferative activity of IFNβ

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Superkines: cytokines displaying better targeted functions

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

The role of RPGR in cilia formation and actin stability

Translational control as the basis of the differential antiproliferative potency of IFNα2 and IFNβ

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands