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List of works by Howard Y. Chang

3D ATAC-PALM: super-resolution imaging of the accessible genome

scientific article published on 16 March 2020

A dermal HOX transcriptional program regulates site-specific epidermal fate

scientific article

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells

scientific article published on 13 May 2020

A histone H3 lysine 27 demethylase regulates animal posterior development

scientific article

A systems biology approach to anatomic diversity of skin

scientific article published on April 2008

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

scientific article published on 06 February 2020

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development

scientific article published on 12 August 2019

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues.

scientific article published on 28 August 2017

Author Correction: Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

scientific article published on 14 December 2020

BRD2 compartmentalizes the accessible genome

scientific article published on 11 April 2022

CRISPR-engineered T cells in patients with refractory cancer

scientific article published on 07 February 2020

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set

scientific article published on 01 December 2020

Challenges and recommendations for epigenomics in precision health.

scientific article published in December 2017

Chromatin accessibility associates with protein-RNA correlation in human cancer

scientific article published on 30 September 2021

Chromatin accessibility dynamics in a model of human forebrain development

scientific article published on 01 January 2020

Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

scientific article published on 17 November 2020

Clonal replacement of tumor-specific T cells following PD-1 blockade

scientific article published on 29 July 2019

Cryptic activation of an Irf8 enhancer governs cDC1 fate specification

scientific article published on 12 August 2019

Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

scientific article

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

scientific article published on 01 July 2021

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.

scientific article published on 25 September 2017

Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

scientific article published on 17 August 2020

Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes

scientific article published on 24 February 2020

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

scientific article

Functional significance of U2AF1 S34F mutations in lung adenocarcinomas

scientific article published on 13 December 2019

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

scientific article published on 31 October 2019

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

scientific article published on 09 July 2018

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

scientific article published on 15 January 2019

HiChIRP reveals RNA-associated chromosome conformation

scientific article published on 27 May 2019

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

scientific article published on 13 July 2020

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

scientific article published in Nature Communications

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

scientific article published on 02 August 2021

Landscape and variation of RNA secondary structure across the human transcriptome

scientific article

Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

scientific article published on 14 August 2017

Locus specific epigenetic modalities of random allelic expression imbalance

scientific article published on 09 September 2021

Long noncoding RNA as modular scaffold of histone modification complexes

scientific article

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

scientific article published on 02 August 2019

Mechanistic insights in X-chromosome inactivation.

scientific article

PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments

scientific article published on 23 November 2021

Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

scientific article published on 30 March 2020

RNA structure maps across mammalian cellular compartments

scientific article published on 18 March 2019

RNA-binding proteins direct myogenic cell fate decisions

scientific article published on 13 June 2022

Rapid chromatin repression by Aire provides precise control of immune tolerance

scientific article published on 15 January 2018

Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment

scientific article published on 05 November 2018

Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

scientific article published on 19 July 2019

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases

scientific article published on 26 October 2020

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

scientific article published on 09 April 2019

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

scientific article published on 02 December 2019

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

scientific article published on 07 May 2020

Structural modularity of the XIST ribonucleoprotein complex

scientific article published on 02 December 2020

The RNA Base-Pairing Problem and Base-Pairing Solutions

scientific article published on 03 December 2018

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

scientific article published on 31 October 2017

The histone demethylase UTX enables RB-dependent cell fate control

scientific article

The novel lncRNA is pro-neurogenic and mutated in human neurodevelopmental disorders

scientific article published on 10 January 2019

The road ahead in genetics and genomics

scientific article published on 24 August 2020

Transcript-indexed ATAC-seq for precision immune profiling.

scientific article published on 23 April 2018

Transcription coactivator and lncRNA duet evoke Hox genes.

scientific article published on 29 June 2017

Tumor suppression by the histone demethylase UTX

scientific article published in June 2010

ecDNA hubs drive cooperative intermolecular oncogene expression

scientific article published on 24 November 2021

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