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List of works by Bruce L. Levine

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

scientific article

A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside

scientific article

A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients

scientific article published on 22 July 2008

A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies

scientific article published on 21 August 2019

A novel dendritic cell-based immunization approach for the induction of durable Th1-polarized anti-HER-2/neu responses in women with early breast cancer.

scientific article published on January 2012

A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells

scientific article published in June 2004

A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation

scientific article published on 3 November 2005

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

scientific article published in July 2017

Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers

scientific article published in August 2015

Accelerating the development of innovative cellular therapy products for the treatment of cancer

scientific article published on 18 March 2020

Activating Signals Dominate Inhibitory Signals in CD137L/IL-15 Activated Natural Killer Cells

scientific article published on March 1, 2011

Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

scientific article published on 19 March 2018

Adoptive T-cell therapy for malignant disorders

scientific article published on 01 October 2008

Adoptive immunotherapy for cancer or viruses

scientific article published on 09 January 2014

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

scientific article published on January 2008

Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.

scientific article published on 23 October 2012

Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.

scientific article published in January 2002

Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation

scientific article published on 22 May 2003

Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells

scientific article

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma

scientific article published on 21 February 2019

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

scientific article published on 19 April 2018

Anti-CD3/anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma

scientific article published on 01 April 2000

Anti-CD3/anti-CD28 monoclonal antibody-coated suture enhances the immune response of patients with head and neck squamous cell carcinoma

scientific article published on 01 November 1999

Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation

scientific article published in June 1996

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

scientific article published on 20 December 2012

Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies

scientific article published on 01 January 2020

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals

scientific article published on 10 November 2020

Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.

scientific article published on January 2013

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma

scientific article published on 21 March 2019

Blocking HIV's attack

scientific article published on 01 March 2012

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

scientific article published in June 1995

CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success

article by Kristen B Long et al published 3 December 2018 in Frontiers in Immunology

CAR T cell viability release testing and clinical outcomes: is there a lower limit?

scientific article published on 01 November 2019

CAR T-cell product performance in haematological malignancies before and after marketing authorisation

scientific article published on 01 February 2020

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

scientific article published on 01 February 2020

CD28 co-receptor signal transduction in T-cell activation

scientific article published on May 1997

CD28 costimulation is essential for human T regulatory expansion and function

scientific article published on August 2008

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro

scientific article published on 01 June 1995

CD28-mediated regulation of multiple myeloma cell proliferation and survival

scientific article published on 20 February 2007

CRISPR-engineered T cells in patients with refractory cancer

scientific article published on 07 February 2020

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction

scientific article published on 01 January 1998

Cancer Killers

scientific article

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

scientific article published on 14 June 2013

Cell therapy medical tourism: time for action

scientific article published on 01 December 2010

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia

scientific article

Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

scientific article

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

scientific article published on 10 December 2017

Chimeric Antigen Receptor T-Cell Therapy for the Community Oncologist

scientific article published on 23 March 2016

Chimeric Antigen Receptor Therapy for B-cell Malignancies

scientific article published on January 1, 2011

Chimeric antigen receptor T cells for sustained remissions in leukemia

scientific article (publication date: 16 October 2014)

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

scientific article published on September 2015

Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods

scientific article published on 13 February 2019

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

scientific article (publication date: 18 April 2013)

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

scientific article

Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor

scientific article published on May 2002

Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells

scientific article

Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.

scientific article

Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy

scientific article published on 31 July 2017

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

scientific article

Convergence of Gene and Cell Therapy

scientific article published on November 1, 2012

Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

scientific article published on 16 September 2004

Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation

scientific article published on 30 January 2012

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

scientific article

Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity

scientific article published on 5 February 2004

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

scientific article published on September 2009

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

scientific article published on 30 April 2018

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children

scientific article published on 01 October 2020

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

scientific article

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

scientific article published in Nature

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

scientific article published on 21 July 2020

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells

scientific article published on December 15, 1997

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

scientific article published on March 6, 2013

Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program

scientific article published on 01 January 2009

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

scientific article

Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells

scientific article published on 01 November 2000

Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies

scientific article published on 07 May 2020

Engineered T cells for cancer therapy.

scientific article

Engineered T cells: the promise and challenges of cancer immunotherapy.

scientific article published on August 2016

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

scientific article

Ex vivo replicative potential of adult human peripheral blood CD4+ T cells

scientific article published on 01 June 1997

Exploring synthetic immunity: From boutique to global

scientific article published on 25 September 2017

Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma.

scientific article

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

scientific article (publication date: 6 March 2014)

Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging

scientific article published in June 2005

Gene transfer in humans using a conditionally replicating lentiviral vector

scientific article

Global Manufacturing of CAR T Cell Therapy

scientific article published on 31 December 2016

HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ.

scientific article published on 17 January 2012

High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses

scientific article

Hope, hype and help: ethically assessing the growing market in stem cell therapies

scientific article published on May 2010

Human naive and memory T lymphocytes differ in telomeric length and replicative potential

scientific article

IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA.

scientific article

ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19

scientific article published on 16 May 2020

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

scientific article published on 26 January 2016

Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

scientific article (publication date: May 2008)

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

scientific article

Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

scientific article published on August 2013

Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4(+) T cells to HIV-infected persons

scientific article published in June 2004

Impaired induction of the apoptosis-protective protein Bcl-xL in activated PBMC from asymptomatic HIV-infected individuals

scientific article published in May 1997

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

scientific article

In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

scientific article published on 18 March 2004

Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells

scientific article published on 01 July 1999

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

scientific article published on 01 October 2018

Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment

scientific article published on 8 February 2016

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

scientific article published on October 15, 2010

Innovation and opportunity for chimeric antigen receptor targeted T cells

scientific article published on 02 April 2013

Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation

scientific article published on June 1997

L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

scientific article published on 3 August 2004

Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation

scientific article published on 01 October 1998

Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells

scientific article

Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia

scientific article published on 16 April 2020

Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

scientific article published on May 2011

Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

scientific article published on February 2014

Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells

scientific article published on January 1, 2004

Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function.

scientific article published on 11 May 2017

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

scientific article published on 05 October 2010

NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.

scientific article

Naı̈ve and Memory CD4 T Cells Differ in Their Susceptibilities to Human Immunodeficiency Virus Type 1 Infection following CD28 Costimulation: Implications for Transmission and Pathogenesis

scientific article published on October 1, 1998

Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma

scientific article published on 20 June 2018

Novel gene and cellular therapy approaches for treating HIV.

scientific article published on April 2016

Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials

scientific article published on 22 November 2016

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia

scientific article published on 09 December 2019

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate

scientific article published on 14 November 2011

Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells

scientific article

PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

scientific article published on 28 December 2016

Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells

scientific article

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

scientific article published in April 2018

Personalized gene therapy locks out HIV, paving the way to control virus without antiretroviral drugs

scientific article published on 07 May 2015

Perspective: Assembly line immunotherapy

scientific article published on June 27, 2013

Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

scientific article published on 20 February 2013

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers

scientific article published on 30 July 2019

Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

scientific article published on September 26, 2011

Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation

scientific article published on 01 November 2006

Phase I clinical trial of donor T-helper type-2 cells after immunoablative, reduced intensity allogeneic PBSC transplant

scientific article published on 01 January 2002

Phase I study of multi-gene cell therapy in patients with peripheral artery disease

scientific article

Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

scientific article published on 22 October 2011

Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling

scientific article published on April 15, 1998

Pilot Study of Prophylactic Ex Vivo Costimulated Donor Leukocyte Infusion After Reduced-Intensity Conditioned Allogeneic Stem Cell Transplantation

scientific article published on April 28, 2013

Powered and controlled T-cell production

scientific article published on 01 March 2018

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

scientific article published on 7 October 2002

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

scientific article

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

scientific article published on 16 May 2010

Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.

scientific article

Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

scientific article published on 20 July 2018

Regulated expression of telomerase activity in human T lymphocyte development and activation

scientific article

Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

scientific article published in April 1997

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

scientific article

Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector

scientific article

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

scientific article published on 16 October 2005

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients

scientific article published on 20 October 2017

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

scientific article published on 6 November 2017

Showcasing Clinical Development and Production of Cellular Therapies

scientific article published on 22 March 2017

Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization

scientific article published on 01 October 1996

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

scientific article

Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma

scientific article

Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

scientific article published on 27 September 2005

Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs

scientific article published on 01 July 2006

T cell engineering as therapy for cancer and HIV: our synthetic future

scientific article

T cells coactivated with immobilized anti-CD3 and anti-CD28 as potential immunotherapy for cancer

scientific article published on 01 July 1999

T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

scientific article published on July 2013

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

scientific article

T lymphocyte engineering ex vivo for cancer and infectious disease

scientific article published in April 2008

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

scientific article published on 01 October 2019

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.

scientific article published on April 2003

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

scientific article published on December 1, 1997

Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.

scientific article

Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins

scientific article

The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.

scientific article published on 23 February 2015

The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells

scientific article published on November 30, 2011

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma

scientific article published on 15 September 2021

The coronavirus pandemic: a pitfall or a fast-track for validating cell therapy products?

scientific article published on 14 December 2020

The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19

scientific article published on 01 February 2020

The peril of the promise of speculative cell banking: Statement from the ISCT Committee on the Ethics of Cell and Gene Therapy

scientific article published on 21 February 2022

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

scientific article published in June 1998

Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

scientific article published on 7 March 2019

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

scientific article published in February 2018

Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.

scientific article

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation

scientific article

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

scientific article published on 12 November 2015

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

scientific article published on 2 August 2016