List of works - Samuel H. Gellman

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

scientific article published on 01 January 2007

A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation

scientific article published on 15 January 2019

Catalytic Intramolecular Conjugate Additions of Aldehyde-Derived Enamines to α,β-Unsaturated Esters

scientific article published on 27 May 2020

Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes

scientific article

Crystal structure of the β2 adrenergic receptor-Gs protein complex

scientific article

Differential Effects of β - versus β -Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3-Derived α/β-Peptides

scientific article published on 20 September 2018

Diverse Impacts on Prokaryotic and Eukaryotic Membrane Activities from Hydrophobic Subunit Variation Among Nylon-3 Copolymers

scientific article published on 11 December 2020

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent

scientific article published on 05 August 2019

Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein

scientific article published on 21 July 2020

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

scientific article

Foldamer Catalysis

scientific article published on 29 September 2020

Foldamer-templated catalysis of macrocycle formation

scientific article published on 03 February 2020

Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

scientific article published on 17 March 2020

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

scientific article

Impact of Substitution Registry on the Receptor-Activation Profiles of Backbone-Modified Glucagon-like Peptide-1 Analogues

scientific article published on 20 September 2019

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

preprint posted on 05 November 2020

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

scientific article published on 17 February 2021

Iterative Nonproteinogenic Residue Incorporation Yields α/β-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF.

scientific article published on 29 November 2016

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

scientific article published on 30 July 2019

Preparation of β2-Homologous Amino Acids Bearing Polar Side Chains via a Collective Synthesis Strategy

scientific article published on 10 January 2020

Receptor selectivity from minimal backbone modification of a polypeptide agonist

scientific article published on 15 November 2018

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids

scientific article published on 07 August 2019

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

scientific article published on 07 May 2015

Retention of Coiled-Coil Dimer Formation in the Absence of Ion Pairing at Positions Flanking the Hydrophobic Core

scientific article published on 18 November 2019

Retention of Native Quaternary Structure in Racemic Melittin Crystals

scientific article published on 06 May 2019

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

scientific article published on 05 October 2021

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

scientific article

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

scientific article

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

scientific article published on 23 January 2020

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

scientific article

Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy

scientific article published on 14 July 2020

Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

scientific article published on 09 September 2019

Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity

scientific article published on 02 May 2019

Versatile Open-Source Photoreactor Architecture for Photocatalysis Across the Visible Spectrum

scientific article published in 2021

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

scientific article published on 28 August 2015

List of works by Samuel H. Gellman

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation

Catalytic Intramolecular Conjugate Additions of Aldehyde-Derived Enamines to α,β-Unsaturated Esters

Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Differential Effects of β - versus β -Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3-Derived α/β-Peptides

Diverse Impacts on Prokaryotic and Eukaryotic Membrane Activities from Hydrophobic Subunit Variation Among Nylon-3 Copolymers

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent

Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Foldamer Catalysis

Foldamer-templated catalysis of macrocycle formation

Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Impact of Substitution Registry on the Receptor-Activation Profiles of Backbone-Modified Glucagon-like Peptide-1 Analogues

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Iterative Nonproteinogenic Residue Incorporation Yields α/β-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF.

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

Preparation of β2-Homologous Amino Acids Bearing Polar Side Chains via a Collective Synthesis Strategy

Receptor selectivity from minimal backbone modification of a polypeptide agonist

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.

Retention of Coiled-Coil Dimer Formation in the Absence of Ion Pairing at Positions Flanking the Hydrophobic Core

Retention of Native Quaternary Structure in Racemic Melittin Crystals

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy

Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity

Versatile Open-Source Photoreactor Architecture for Photocatalysis Across the Visible Spectrum

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells