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List of works by Thaddeus S. Stappenbeck

A Common Mechanism Links Activities of Butyrate in the Colon

scientific article published on 10 April 2018

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

scientific article

A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19

scientific article published on 02 July 2020

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability

scientific article published on 20 June 2019

A common mechanism links activities of butyrate in the colon

scientific article published in 2017

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease

scientific article published on 8 February 2009

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

scientific article (publication date: 13 November 2008)

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

scientific article published on 06 November 2020

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

scientific article

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

scientific article published on 25 April 2018

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease

scientific article published on 18 May 2018

Accounting for reciprocal host-microbiome interactions in experimental science

scientific article

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

scientific article

Adaptive immunity restricts replication of novel murine astroviruses

scientific article

Altered intestinal ACE2 levels are associated with inflammation, severe disease and response to anti-cytokine therapy in IBD

scientific article published on 02 November 2020

An antibiotic-responsive mouse model of fulminant ulcerative colitis

scientific article

Angiogenins: a new class of microbicidal proteins involved in innate immunity

scientific article

Assigning function to symbionts

scientific article published in January 2018

Atg14 protects the intestinal epithelium from TNF-triggered villus atrophy

scientific article published on 03 April 2019

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

scientific article

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection

scientific article published on 21 August 2013

Autophagy and Intestinal Homeostasis ⬇️

scientific article published on 03 December 2012

Autophagy proteins are required for club cell structure and function in airways

scientific article published on 22 May 2019

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

scientific journal article

B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.

scientific article published on 2 November 2017

BHLHE40 Promotes TH2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines

scientific article published on 03 January 2020

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

scientific article published on 06 May 2019

Biofilm Formation and Virulence of Shigella flexneri Are Modulated by pH of Gastrointestinal Tract

scientific article published on 16 August 2021

Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly

scientific article

Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.

scientific article published on 26 August 2016

Cellular differentiation: Potential insight into butyrate paradox?

scientific article published on 27 February 2018

Challenges in IBD Research: Preclinical Human IBD Mechanisms

scientific article published on 01 May 2019

Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda

scientific article published on March 2013

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

scientific article published on May 2015

Colonic epithelial response to injury requires Myd88 signaling in myeloid cells

scientific article published on 18 January 2012

Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease

scientific article

Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells

scientific article

Counteracting stem cell expansion during wound repair: distinct roles of non-canonical Wnt and TGF-β.

scientific article published on 16 January 2013

Crohn disease: a current perspective on genetics, autophagy and immunity

scientific article

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

scientific article

Deciphering the 'black box' of the intestinal stem cell niche: taking direction from other systems

scientific article published on March 2008

Deep Learning Global Glomerulosclerosis in Transplant Kidney Frozen Sections

scientific article published on 27 June 2018

Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis ⬇️

scientific article published on August 1, 2012

Desmoplakin expression and distribution in cultured rat bladder epithelial cells of varying tumorigenic potential

scientific article published on March 1991

Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis

scientific article

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.

scientific article

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

scientific article

Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen

scientific article published on 01 February 2019

Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter

scientific article

Disease-specific alterations in the enteric virome in inflammatory bowel disease

scientific article

Diverse adult stem cells share specific higher-order patterns of gene expression.

scientific article published on 29 May 2008

Diversity of the autochthonous colonic microbiota

scientific article

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium

scientific article published on 28 May 2015

ELMO1 regulates the induction of autophagy and bacterial clearance during enteric infection.

scientific article

Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition

scientific article

Efficient colonic mucosal wound repair requires Trem2 signaling

scholarly article

Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease

scientific article published on 23 September 2020

Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice

scientific article

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.

scientific article

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

scientific article published on 24 July 2008

Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks ⬇️

scientific article published on November 1, 1993

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

scientific article

Genetic mosaic analysis based on Cre recombinase and navigated laser capture microdissection

scientific article

Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

scientific article

Genetics and Pathogenesis of Inflammatory Bowel Disease

scientific article published on 22 February 2016

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

scientific article

Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells

scientific article

Gut-Pancreatic Axis AMPlified in Islets of Langerhans.

scientific article published on August 2015

Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation

scientific article published on July 2017

Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

scientific article

Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease.

scientific article

Host pathogens. Editorial overview

scientific article published on 17 August 2011

Host-microbe interactions shaping the gastrointestinal environment

scientific article

IL-6 stimulates intestinal epithelial proliferation and repair after injury

scientific article

IL13 activates autophagy to regulate secretion in airway epithelial cells

scientific article published on 10 June 2015

IgG "detoxes" the intestinal mucosa

scientific article published in May 2015

Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.

scientific article published on 27 March 2012

Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups

scientific article published on 01 August 2019

Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase.

scientific article

In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers

scientific article published on 01 January 2020

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture.

scientific article

Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.

scientific article published on 24 October 2014

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease

scientific article published on 15 October 2018

Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses

scientific article published on 04 October 2018

Intestinal Stem Cells Live Off the Fat of the Land

scientific article published on 01 May 2018

L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams.

scientific article published on 27 March 2019

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients

scientific article published on 23 March 2017

Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner.

scientific article

Laminin alpha 5 influences the architecture of the mouse small intestine mucosa

scientific article published on 15 July 2008

Laser capture microdissection of mouse intestine: characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations

scientific article

Living and commuting in intestinal crypts

scientific article published on 01 January 1999

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

scientific article published on 07 November 2019

Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease.

scientific article published on 15 August 2013

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease.

scientific article published on 2 December 2013

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

scientific article published on February 2007

Mesenchymal stem cell therapy of intestinal disease: are their effects systemic or localized?

scientific article

Microbiome control of innate reactivity

scientific article published on 22 January 2019

Molecular characterization of mouse gastric epithelial progenitor cells

scientific article

Molecular characterization of mouse gastric zymogenic cells.

scientific article

Molecular features of adult mouse small intestinal epithelial progenitors

scientific article

Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches

scientific article published on 7 February 2006

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro.

scientific article

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

scientific article

Mucus, it is not just a static barrier

scientific article published on 29 April 2014

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

scientific article published on 29 May 2019

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

scientific article

NOD2 status and human ileal gene expression.

scientific article published on October 2010

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

scientific journal article

Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium

scientific article published on 01 December 1998

Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice

scientific article

Organoids in gastrointestinal diseases: from experimental models to clinical translation

scientific article published in 2022

PAI-1 augments mucosal damage in colitis

scientific article published on 01 March 2019

Paneth Cell Alterations in the Development and Phenotype of Crohn's Disease

scientific article published on 8 October 2016

Paneth cell defects in Crohn's disease patients promote dysbiosis

scientific article published on 02 June 2016

Paneth cell development, differentiation, and function: new molecular cues

scientific article published on 02 June 2009

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome

scientific article

Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model

scientific article published on 02 March 2020

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells

scientific article

Peripheral education of the immune system by colonic commensal microbiota.

scientific article

Peripheral education of the immune system by the colonic microbiota

scientific article

Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine

scientific article published on 03 January 2020

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

scientific article published on 24 October 2016

Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine

scientific article published on 01 June 2000

Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development

scientific journal article

Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn′s disease

scientific article published on 23 April 2020

Representation Learning for Person or Entity-Centric Knowledge Graphs: An Application in Healthcare

scientific article published on 28 November 2023

Response from Jeffrey I. Gordon et al.: Commensal bacteria make a difference

scientific article published on 01 April 2003

Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion

scholarly article

Role of autophagy and autophagy genes in inflammatory bowel disease

scientific article published on January 2009

Role of microbes in the adaptation of the colonic epithelial progenitor niche during injury

scientific article published on April 2008

Role of viruses and bacteria-virus interactions in autoimmunity

scientific article

Runx3 specifies lineage commitment of innate lymphoid cells

scientific article

Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells

scientific article

Spatial and temporal stability of paneth cell phenotypes in Crohn's disease: implications for prognostic cellular biomarker development

scientific article published on April 2014

Spatial organization of intestinal microbiota in the mouse ascending colon

scientific article

Structure and function of desmosomal transmembrane core and plaque molecules

scientific article published on May 1994

Structure of Desmoplakin and Its Association with Intermediate Filaments ⬇️

scientific article published on 01 November 1992

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

scientific article published on 24 September 2018

Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration

scientific article published on 16 August 2018

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

scientific article

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

scientific article published on 01 November 2016

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis

scientific article published on 08 July 2020

The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells ⬇️

scientific article published on March 1, 1992

The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1

scientific article

The microbial metabolite desaminotyrosine protects from influenza through type I interferon.

scientific article

The role of autophagy in Paneth cell differentiation and secretion

scientific article published on 04 November 2009

The role of stromal stem cells in tissue regeneration and wound repair.

scientific article

The stem cell niche

scientific article published on January 2009

The young and the Wnt-less: transplantable fetal intestinal spheroids without Wnts.

scientific article published on December 2013

Tracking cell lineage to rediscover (again) the switch from ciliated to mucous cells

scientific article published in March 2011

Type I interferons link viral infection to enhanced epithelial turnover and repair.

scientific article

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation

scientific article

Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.

scientific article published on 12 January 2009

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

scientific article published on 16 February 2015

Viral interactions with the host and microbiota in the intestine ⬇️

scientific article published on May 22, 2012

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

scientific article

Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury ⬇️

scientific article published on September 6, 2012

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