List of works - Jürgen Brem

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

scientific article published on 5 July 2017

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

scientific article published on 2 March 2017

19 F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition

scientific article published on 20 August 2019

A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2

scientific article published on 08 November 2019

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

scientific article

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.

scientific article published on 30 June 2015

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

scientific article published on 16 September 2019

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

scientific article published on 12 June 2020

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

scientific article

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

scientific article published on 20 July 2015

Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate

scientific article published on 06 January 2020

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

scientific article

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

scientific article published on 28 April 2016

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

scientific article

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

scientific article

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

scientific article

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

scientific article published in May 2017

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

scientific article published on 10 January 2020

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

scientific article published on 17 December 2017

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

scientific article published on 19 September 2014

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

scientific article published on 22 December 2017

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

scientific article published on 06 January 2017

Interaction of Avibactam with Class B Metallo-β-Lactamases

scientific article

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

scientific article published on 20 September 2019

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

scientific article published on 23 September 2019

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy

scientific article published on 24 February 2014

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

scientific article published on 14 December 2016

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

scientific article published on 2 October 2017

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

scientific article published on 21 January 2019

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

scientific article

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

scientific article published on 2 May 2016

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

scientific article published on 9 October 2013

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

scientific article

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

scientific article published on 16 November 2020

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

scientific article published on 18 July 2016

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ⬇️

scientific article published on 8 August 2016

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

scientific article published on 6 September 2017

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

scientific article published on 4 November 2014

Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen

scientific article published on 01 August 2019

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

scientific article

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam

scientific article published on 21 June 2016

Use of ferrous iron by metallo-β-lactamases

scientific article

Will morphing boron-based inhibitors beat the β-lactamases?

scientific article published on 18 April 2019

List of works by Jürgen Brem

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

19 F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition

A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

Interaction of Avibactam with Class B Metallo-β-Lactamases

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ⬇️

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam

Use of ferrous iron by metallo-β-lactamases

Will morphing boron-based inhibitors beat the β-lactamases?