List of works - Hans C Oettgen

A beneficial role for immunoglobulin E in host defense against honeybee venom

scientific article

A humanized mouse model of anaphylactic peanut allergy.

scientific article published on 8 June 2016

A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis

scientific article

Adaptive immunity

scientific article published on 12 January 2010

Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance.

scientific article published on 4 May 2017

An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis.

scientific article

Anti-IgE therapy: clinical utility and mechanistic insights.

scientific article published on January 2015

Antigen-independent effects of immunoglobulin E.

scientific article

Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

scientific article

Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma

scientific article published in July 2003

Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy ⬇️

scientific article published on November 14, 2012

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice

scientific article published in June 2011

Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma

scientific article

Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.

scientific article published on February 2013

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.

scientific article

Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases

scientific article published on June 2016

Food allergy

Food allergy: Insights into etiology, prevention, and treatment provided by murine models.

scientific article published on February 2014

High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

scientific article published on 27 May 2011

IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum.

scientific article

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.

scientific article published on 15 December 2008

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

scientific article published on 18 April 2016

IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy

scientific article published on 11 December 2020

IgE and Mast Cells: The Endogenous Adjuvant.

scientific article published on 25 March 2015

IgE and mast cells: The endogenous adjuvant

scientific article published on 05 November 2020

IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies

scientific article published on 04 November 2018

IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis

scientific article

IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation

scientific article

IgE promotes type 2 innate lymphoid cells in murine food allergy.

scientific article

IgE receptor signaling in food allergy pathogenesis.

scientific article published on 18 August 2015

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells.

scientific article

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE.

scientific article published in April 2004

Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells

scientific article

Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation

scientific article published on 24 September 2007

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif

scientific article

Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation

scientific article published on 09 April 2009

Mast Cells as Regulators of Adaptive Immune Responses in Food Allergy

scientific article published on 29 December 2020

Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation

scientific article published on 01 January 2002

Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection

scientific article

Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice

scientific article published on 16 March 2020

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

scientific article

Polyclonal IgE induces mast cell survival and cytokine production

scientific article

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

scientific article published in October 2008

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

scientific article published on 14 October 2020

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

scientific article published on 01 December 2020

Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy

scientific article

Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

scientific article published on 14 June 2010

TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation

scientific article published on 01 February 2008

TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.

scientific article

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation

scientific article

The H1 histamine receptor regulates allergic lung responses.

scientific article

The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.

scientific article

The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE-mediated mast cell responses

scientific article published on 20 November 2018

Tissue-Specific Expression of the Low-Affinity IgG Receptor, FcγRIIb, on Human Mast Cells.

scientific article

Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response

scientific article published on 17 August 2009

List of works by Hans C Oettgen

A beneficial role for immunoglobulin E in host defense against honeybee venom

A humanized mouse model of anaphylactic peanut allergy.

A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis

Adaptive immunity

Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance.

An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis.

Anti-IgE therapy: clinical utility and mechanistic insights.

Antigen-independent effects of immunoglobulin E.

Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma

Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy ⬇️

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice

Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma

Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.

Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases

Food allergy

Food allergy: Insights into etiology, prevention, and treatment provided by murine models.

High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum.

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy

IgE and Mast Cells: The Endogenous Adjuvant.

IgE and mast cells: The endogenous adjuvant

IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies

IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis

IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation

IgE promotes type 2 innate lymphoid cells in murine food allergy.

IgE receptor signaling in food allergy pathogenesis.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells.

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE.

Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells

Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif

Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation

Mast Cells as Regulators of Adaptive Immune Responses in Food Allergy

Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation

Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection

Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

Polyclonal IgE induces mast cell survival and cytokine production

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy

Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation

TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation

The H1 histamine receptor regulates allergic lung responses.

The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.

The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE-mediated mast cell responses

Tissue-Specific Expression of the Low-Affinity IgG Receptor, FcγRIIb, on Human Mast Cells.

Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response