List of works - Giuseppe Passarino

The role of selection in the evolution of human mitochondrial genomes

scientific article

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

scientific article

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern

scientific article published on 26 June 2013

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

scientific article

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma.

scientific article published on October 2012

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

scientific article

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease

scientific article

Handgrip strength among nonagenarians and centenarians in three European regions

scientific article published in July 2006

Global DNA Methylation Levels are Modulated by Mitochondrial DNA Variants

scientific article published on February 1, 2012

miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells

scientific article published on 25 September 2013

Global DNA methylation in old subjects is correlated with frailty.

scientific article published on 19 February 2011

Association of the mitochondrial DNA haplogroup J with longevity is population specific

scientific article published on 01 December 2004

Frailty phenotypes in the elderly based on cluster analysis: a longitudinal study of two Danish cohorts. Evidence for a genetic influence on frailty

scientific article published on 13 May 2011

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

scientific article

Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms

scientific article (publication date: September 2002)

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity

scientific article

Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.

scientific article published on 08 August 2013

Human longevity and 11p15.5: a study in 1321 centenarians

scientific article

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

scientific article (publication date: February 2010)

Epigenetics and aging

scientific article published on 12 December 2012

Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals

scientific article published on 17 October 2011

Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines.

scientific article published on August 2006

Sex and age specificity of susceptibility genes modulating survival at old age.

scientific article published on 22 November 2006

APOE polymorphism affects episodic memory among non demented elderly subjects.

scientific article published on 24 November 2008

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes

scientific article published on May 2013

Human longevity: Genetics or Lifestyle? It takes two to tango

scientific article

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.

scientific article published on 27 January 2012

A novel, population-specific approach to define frailty

scientific article

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

scientific article

Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

scientific article published on 28 November 2016

Mitochondrial DNA involvement in human longevity

scientific article published on 7 June 2006

Targeting inflammation to slow or delay functional decline: where are we?

scientific article published on 15 June 2010

The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians

scientific article published on June 2008

Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

scientific article

Relationship between renal function and physical performance in elderly hospitalized patients

scientific article published on 24 September 2012

The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians.

scientific article

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells

scientific article published on January 1, 2012

Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians

scientific article

Mitochondria in health, aging and diseases: the epigenetic perspective.

scientific article

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome

scientific article published on 5 April 2017

Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity

article

Bitter taste receptor polymorphisms and human aging

scientific article

Resistance of mtDNA-depleted cells to apoptosis

scientific article

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

scientific article published on June 1, 2014

Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.

scientific article

Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics

scientific article published on July 2007

List of works by Giuseppe Passarino

The role of selection in the evolution of human mitochondrial genomes

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Interventions to Slow Aging in Humans: Are We Ready?

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma.

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease

Handgrip strength among nonagenarians and centenarians in three European regions

Global DNA Methylation Levels are Modulated by Mitochondrial DNA Variants

miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells

Global DNA methylation in old subjects is correlated with frailty.

Association of the mitochondrial DNA haplogroup J with longevity is population specific

Frailty phenotypes in the elderly based on cluster analysis: a longitudinal study of two Danish cohorts. Evidence for a genetic influence on frailty

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity

Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.

Human longevity and 11p15.5: a study in 1321 centenarians

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

Epigenetics and aging

Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals

Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines.

Sex and age specificity of susceptibility genes modulating survival at old age.

APOE polymorphism affects episodic memory among non demented elderly subjects.

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes

Human longevity: Genetics or Lifestyle? It takes two to tango

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.

A novel, population-specific approach to define frailty

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

Mitochondrial DNA involvement in human longevity

Targeting inflammation to slow or delay functional decline: where are we?

The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians

Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

Relationship between renal function and physical performance in elderly hospitalized patients

The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians.

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells

Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians

Mitochondria in health, aging and diseases: the epigenetic perspective.

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome

Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity

Bitter taste receptor polymorphisms and human aging

Resistance of mtDNA-depleted cells to apoptosis

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.

Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics