List of works - Alessandra Bitto

Adenosine Receptor Stimulation Improves Glucocorticoid-Induced Osteoporosis in a Rat Model

scientific article published on 5 September 2017

Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis

scientific article published on 23 August 2016

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression

scientific article published on 01 June 2008

Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial.

scientific article published on 22 February 2017

BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis

scientific article published on 17 January 2017

Blockade of the JNK signalling as a rational therapeutic approach to modulate the early and late steps of the inflammatory cascade in polymicrobial sepsis.

scientific article

Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study.

scientific article

CO2 pneumoperitoneum preserves β-arrestin 2 content and reduces high mobility group box-1 (HMGB-1) expression in an animal model of peritonitis.

scientific article published on 24 February 2015

Cadmium delays puberty onset and testis growth in adolescents

scientific article published on 18 December 2014

Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents.

scientific article

Cardiovascular effects of the phytoestrogen genistein.

scientific article published in April 2004

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

scientific article published on 26 March 2019

Dietary Management of Skin Health: The Role of Genistein

scientific article

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

scientific article published on 25 February 2017

Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial.

scientific article

Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study

scientific article

Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice

scientific article published on 26 November 2017

Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. ⬇️

scientific article published on 22 May 2007

Epigenetic modifications due to heavy metals exposure in children living in polluted areas

scientific article

Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury.

scientific article

Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women ⬇️

scientific article published on May 9, 2011

Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury.

scientific article

Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis.

scientific article

Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases.

scientific article published on July 2017

Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant ⬇️

scientific article published on June 19, 2011

Flavocoxid, a nutraceutical approach to blunt inflammatory conditions.

scientific article published on 24 August 2014

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

scientific article

Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats

scientific article published in February 2012

Genomic Variations Affecting Biological Effects of Statins

scientific article published on 18 February 2016

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

scientific article

Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases

scientific article published on 10 March 2016

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice.

scientific article published on May 2014

Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene

scientific article

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

scientific article

Levels of heavy metals in adolescents living in the industrialised area of Milazzo-Valle del Mela (northern Sicily).

scientific article

Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.

scientific article

Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds.

scientific article published in July 2005

Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antiinflammatory pathway

scientific article

Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway.

scientific article published in May 2011

Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia

scientific article

Melanocortins as potential therapeutic agents in severe hypoxic conditions

scientific article published on 17 April 2012

Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease

scientific article

Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.

scientific article published in October 2013

Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

scientific article

Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering.

scientific article

NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice.

scientific article

Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.

scientific article published on 5 June 2007

Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity

article

Oxidative Stress: Harms and Benefits for Human Health

scientific article published on 27 July 2017

Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy).

scientific article

Pharmacokinetic/pharmacodynamic drug interaction between rosiglitazone and mycophenolate mofetil in kidney transplantation: a case report

scientific article

Pharmacokinetics of mycophenolate sodium and comparison with the mofetil formulation in stable kidney transplant recipients

scientific article published on 10 October 2007

Pharmacological Activity and Clinical Use of PDRN.

scientific article

Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease

scientific article

Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers

scientific article published on October 2009

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.

scientific article

Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

scientific article (publication date: 10 January 2017)

Polyethylene glycol formulations show different soft tissue remodeling and angiogenesis features

scientific article

Propylthiouracil modulates aortic vasculopathy in the oxidative stress model of systemic sclerosis.

scientific article

Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

scientific article published on 16 September 2013

Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats

scientific article

Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*.

scientific article published in March 2012

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

scientific article

Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds

scientific article published on 01 April 2006

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice ⬇️

scientific article published on December 2013

Role of AHR, AHRR and ARNT in response to dioxin-like PCBs in Spaurus aurata

scientific article

Skin Involvement and Pulmonary Hypertension Are Associated with Vitamin D Insufficiency in Scleroderma

scientific article published on 14 December 2016

The ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with fibrinogen plasma levels in postmenopausal women.

scientific article published on 11 August 2012

The ESR2 AluI gene polymorphism is associated with bone mineral density in postmenopausal women.

scientific article published on 13 June 2011

Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery

scientific article

Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.

scientific article

Update on genistein and thyroid: an overall message of safety

scientific article

Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis

scientific article published on 20 July 2016

List of works by Alessandra Bitto

Adenosine Receptor Stimulation Improves Glucocorticoid-Induced Osteoporosis in a Rat Model

Adenosine Receptor Stimulation by Polydeoxyribonucleotide Improves Tissue Repair and Symptomology in Experimental Colitis

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression

Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial.

BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis

Blockade of the JNK signalling as a rational therapeutic approach to modulate the early and late steps of the inflammatory cascade in polymicrobial sepsis.

Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study.

CO2 pneumoperitoneum preserves β-arrestin 2 content and reduces high mobility group box-1 (HMGB-1) expression in an animal model of peritonitis.

Cadmium delays puberty onset and testis growth in adolescents

Cadmium-Induced Oxidative Stress Impairs Glycemic Control in Adolescents.

Cardiovascular effects of the phytoestrogen genistein.

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

Dietary Management of Skin Health: The Role of Genistein

Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice

Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial.

Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study

Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice

Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. ⬇️

Epigenetic modifications due to heavy metals exposure in children living in polluted areas

Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury.

Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women ⬇️

Evidence for a role of mitogen-activated protein kinase 3/mitogen-activated protein kinase in the development of testicular ischemia-reperfusion injury.

Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis.

Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases.

Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant ⬇️

Flavocoxid, a nutraceutical approach to blunt inflammatory conditions.

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats

Genomic Variations Affecting Biological Effects of Statins

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice.

Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

Levels of heavy metals in adolescents living in the industrialised area of Milazzo-Valle del Mela (northern Sicily).

Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.

Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds.

Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antiinflammatory pathway

Melanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway.

Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia

Melanocortins as potential therapeutic agents in severe hypoxic conditions

Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease

Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways.

Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering.

NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice.

Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.

Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity

Oxidative Stress: Harms and Benefits for Human Health

Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy).

Pharmacokinetic/pharmacodynamic drug interaction between rosiglitazone and mycophenolate mofetil in kidney transplantation: a case report

Pharmacokinetics of mycophenolate sodium and comparison with the mofetil formulation in stable kidney transplant recipients

Pharmacological Activity and Clinical Use of PDRN.

Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease

Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.

Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

Polyethylene glycol formulations show different soft tissue remodeling and angiogenesis features

Propylthiouracil modulates aortic vasculopathy in the oxidative stress model of systemic sclerosis.

Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats

Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*.

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice ⬇️

Role of AHR, AHRR and ARNT in response to dioxin-like PCBs in Spaurus aurata

Skin Involvement and Pulmonary Hypertension Are Associated with Vitamin D Insufficiency in Scleroderma

The ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with fibrinogen plasma levels in postmenopausal women.

The ESR2 AluI gene polymorphism is associated with bone mineral density in postmenopausal women.

Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery

Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock.

Update on genistein and thyroid: an overall message of safety

Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis