List of works - Luca Gattinoni

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

scientific article

AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8 T cells for adoptive immunotherapy

scientific article published on 06 August 2018

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

scientific article

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

scientific article published on 17 September 2008

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

scientific article published on 24 September 2009

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

scientific article

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

scientific article published on 11 February 2021

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

scientific article published on 09 May 2016

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

scientific article

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

scientific article

CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential

scientific article published on 18 November 2019

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

scientific article

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

scientific article

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

scholarly article

Enhancing adoptive T cell immunotherapy with microRNA therapeutics

scientific article published on 19 December 2015

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity.

scientific article published on 14 December 2017

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

scientific article

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

scientific article published on February 2007

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

scientific article

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

scientific article

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

scientific article

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

scientific article published on 14 February 2008

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

scientific article

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

scientific article published on January 2010

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

scientific article published on 16 September 2013

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

scientific article

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

scientific article

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

scientific article published on 14 December 2015

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

scientific article published on April 2013

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 T cells via TLR4 signaling

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

scientific article published in August 2007

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

scientific article published on 7 December 2015

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

scientific article published on 4 December 2012

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

scientific article

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

scientific article

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

scientific article published on 26 June 2009

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

scientific article

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

scientific article published on 02 September 2013

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

scientific article published on 17 June 2019

T memory stem cell formation: Caveat mTOR.

scientific article published on 11 February 2016

T memory stem cells in health and disease.

scientific article published on January 2017

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

Th17 cells are long lived and retain a stem cell-like molecular signature

scientific article

Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion

scientific article published on 09 March 2017

The dark side of T memory stem cells.

scientific article published on June 2015

The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses

scientific article

The transcription factor BACH2 promotes tumor immunosuppression.

scientific article published on 5 January 2016

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

scientific article published on 18 February 2019

Toll-like receptors in tumor immunotherapy

scientific article

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

scientific article

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

scientific article published on 12 October 2020

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

scientific article

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

scientific article

Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy ⬇️

scientific article published on August 5, 2010

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

scientific article

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8 T cell fate

scientific article published on 14 May 2019

miR-155 releases the brakes on antitumor T cells

scientific article

List of works by Luca Gattinoni

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8 T cells for adoptive immunotherapy

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

Enhancing adoptive T cell immunotherapy with microRNA therapeutics

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity.

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 T cells via TLR4 signaling

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination.

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

T memory stem cell formation: Caveat mTOR.

T memory stem cells in health and disease.

T-cell receptor gene therapy of established tumors in a murine melanoma model

Th17 cells are long lived and retain a stem cell-like molecular signature

Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion

The dark side of T memory stem cells.

The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses

The transcription factor BACH2 promotes tumor immunosuppression.

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

Toll-like receptors in tumor immunotherapy

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy ⬇️

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8 T cell fate

miR-155 releases the brakes on antitumor T cells