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List of works by Yosuke Hashimoto

A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics

scientific article published on 02 October 2018

A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes

scientific article published on 17 October 2018

A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes

scientific article published on 17 February 2018

Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production

scientific article published on 3 April 2014

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs

scientific article published on 07 December 2018

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

scientific article published on 24 June 2015

Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells

scientific article published on 6 June 2015

B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice.

scientific article published on 13 April 2014

Chemistry, properties, and in vitro and in vivo applications of 2'-O-methoxyethyl-4'-thioRNA, a novel hybrid type of chemically modified RNA

scientific article published on 14 October 2014

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.

scientific article published on 17 August 2017

Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.

scientific article

Comprehensive analysis of PEGylated liposome-associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods.

scientific article published on 4 September 2014

Current progress in a second-generation claudin binder, anti-claudin antibody, for clinical applications.

scientific article

Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody.

scientific article published on 27 September 2016

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5.

scientific article

Gene Silencing Using 4'-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response

scientific article published on 5 January 2016

Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model

scientific article published on 7 June 2016

Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs

scientific article published on 12 March 2014

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1

scientific article published on 17 August 2019

Relationship between the concentration of anti-polyethylene glycol (PEG) immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice

scientific article published in January 2015

Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers

scientific article published on 15 September 2016

Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.

scientific article published on 12 February 2018

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