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List of works by Jonathan Hirst

15-Hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition.

scientific article

A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment

scientific article published on 15 December 2018

Administration of Progesterone Throughout Pregnancy Increases Maternal Steroids Without Adverse Effect on Mature Oligodendrocyte Immunostaining in the Guinea Pig.

scientific article published in January 2017

Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep

scientific article

Allopregnanolone in the brain: protecting pregnancy and birth outcomes.

scientific article published on 04 September 2013

Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?

scientific article published on 21 July 2018

Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus

scientific article published on 11 December 2018

Blocked, delayed, or obstructed: What causes poor white matter development in intrauterine growth restricted infants?

scientific article published on 6 April 2017

Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency.

scientific article published on 13 June 2008

Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation

scientific article published on 3 June 2016

Cerebrovascular responses in the fetal sheep brain to low-dose endotoxin

scientific article published on 18 February 2004

Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization

scientific article published on 20 August 2003

Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep

scientific article published on 19 March 2003

Changes in human placental 5alpha-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure

scientific article published in January 2009

Changes in neuroactive steroid concentrations after preterm delivery in the Guinea pig

scientific article published on 12 April 2013

Delay of preterm birth in sheep by THG113.31, a prostaglandin F2alpha receptor antagonist

scientific article published in July 2005

Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth

scientific article

Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.

scientific article

Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model.

scientific article published on 15 May 2017

Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period

scientific article published on 26 November 2020

Effects of prenatal stress on fetal neurodevelopment and responses to maternal neurosteroid treatment in Guinea pigs

scientific article published on 19 September 2013

Endotoxin increases sleep and brain allopregnanolone concentrations in newborn lambs

scientific article published in December 2002

Fetal responses to maternal and intra-amniotic lipopolysaccharide administration in sheep

scientific article published on 11 December 2002

Ganaxolone versus Phenobarbital for Neonatal Seizure Management

scientific article published in 2022

Ganaxolone: A New Treatment for Neonatal Seizures.

scientific article published on 22 August 2017

Genes upregulated in the amnion at labour are bivalently marked by activating and repressive histone modifications

scientific article published on 01 April 2019

Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain

scientific article published on 23 June 2006

Identification of bactenecin-1 in cervicovaginal fluid by two-dimensional electrophoresis in an ovine model of preterm labour

scientific article published on 01 January 2007

Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: up-regulation by inflammatory stimuli and with clinical infection

scientific article published in January 2005

Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion

scientific article

Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero

scientific article

Increased expression of alpha-enolase in cervico-vaginal fluid during labour

scientific article

Increased placental neurosteroidogenic gene expression precedes poor outcome in the preterm guinea pig.

scientific article published in April 2014

Inflammatory and steroid receptor gene methylation in the human amnion and decidua

scientific article published on 18 March 2013

Injury of the developing cerebellum: a brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus.

scientific article published on December 2014

Invited review: guinea pig models for translation of DOHaD into the clinic.

scientific article published on 6 April 2018

Labor-associated regulation of prostaglandin E and F synthesis and action in the ovine amnion and cervix.

scientific article published on 21 November 2005

Late stage functionalization via Chan-Lam amination: rapid access to potent and selective integrin inhibitors

scientific article published on 04 March 2020

Long-term effects of preterm birth on behavior and neurosteroid sensitivity in the guinea pig.

scientific article

Loss of neurosteroid-mediated protection following stress during fetal life.

scientific article published on 10 September 2015

Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum

scientific article

Mechanisms leading to increased risk of preterm birth in growth-restricted guinea pig pregnancies

scientific article published on 24 July 2013

Molecular evidence of a (pro)renin/ (pro)renin receptor system in human intrauterine tissues in pregnancy and its association with PGHS-2

scientific article published on 11 August 2010

Neuroactive steroids in pregnancy: key regulatory and protective roles in the foetal brain.

scientific article published on 10 May 2013

Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states.

scientific article published on 9 September 2010

Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs

scientific article published on 20 September 2018

Neurosteroids for a successful pregnancy

scientific article published in January 2011

Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies

scientific article published on 02 August 2007

PTGS2 (prostaglandin endoperoxide synthase-2) expression in term human amnion in vivo involves rapid mRNA turnover, polymerase-II 5'-pausing, and glucocorticoid transrepression.

scientific article published on 8 March 2011

Perinatal compromise contributes to programming of GABAergic and glutamatergic systems leading to long-term effects on offspring behaviour

scientific article published on 09 December 2019

Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood.

scientific article

Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs.

scientific article published on 9 February 2015

Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins

scientific article

Progesterone receptor isoform expression in the guinea pig myometrium from normal and growth restricted pregnancies

scientific article published in August 2010

Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero.

scientific article published in July 2002

Prostaglandin e and f receptor expression and myometrial sensitivity at labor onset in the sheep

scientific article published on 15 December 2004

Reduced Neurosteroid Exposure Following Preterm Birth and Its' Contribution to Neurological Impairment: A Novel Avenue for Preventative Therapies

scientific article published on 15 May 2019

Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring

scientific article published on 22 April 2016

Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development

scientific article

Steroid hormone receptors in the adrenal glands of fetal and adult rhesus monkeys ⬇️

scientific article published on July 1, 1992

Steroid-sensitive GABAA receptors in the fetal sheep brain.

scientific article published in September 2003

Stress in pregnancy activates neurosteroid production in the fetal brain

scientific article published on 11 December 2006

Stress in pregnancy: a role for neuroactive steroids in protecting the fetal and neonatal brain

scientific article published on 15 August 2009

The guinea pig as an animal model for studying perinatal changes in microvascular function

scientific article

The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes

scientific article published on 18 May 2006

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