List of works by Gemma Casadesus

A metabolic basis for Alzheimer disease

scientific article published on October 2003

A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease

scientific article published in March 2009

Accumulation of intraneuronal amyloid-β is common in normal brain.

scientific article

Activation of Akt by lithium: pro-survival pathways in aging

scientific article published on 3 January 2009

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

scientific article published on 27 March 2012

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

scientific article

Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species

scientific article published on April 2004

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

scientific article

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

scholarly article

Antioxidant approaches for the treatment of Alzheimer's disease

scientific article published on July 2010

Automated Isoform Diversity Detector (AIDD): a pipeline for investigating transcriptome diversity of RNA-seq data

scientific article published on 30 December 2020

Autophagy in Alzheimer's disease

scientific article published on July 2010

Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease

scientific article published in August 2004

CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity

scientific article published on 13 February 2019

Cell cycle aberrations in Alzheimer's disease: a novel therapeutic opportunity

scientific article published on 01 November 2009

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

scientific article published on 09 December 2008

Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

scientific article published in June 2004

Chapter 19. Targeting Oxidative Mechanisms in Alzheimer Disease

Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease

scientific article published in December 2009

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

scientific article published on February 2009

Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, and Luigi Puglielli.

scientific article published in July 2005

Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

scientific article

Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits

scientific article

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

scientific article published on 21 August 2013

Early Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer's Disease.

scientific article published on 27 July 2017

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.

scientific article

Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis

scientific article

Evidence for the role of luteinizing hormone in Alzheimer disease

scientific article published on December 2007

Experimental models for aging and their potential for novel drug discovery.

scientific article

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

scientific article published on 11 September 2008

Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain

scientific article

Food Antioxidants and Alzheimer’s Disease

article

From Neurodegeneration to Brain Health: An Integrated Approach.

scientific article published on 26 February 2015

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

scientific article published on December 2008

Frontiers in Alzheimer's disease therapeutics

scientific article

Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis

scientific article

Gonadotropins: a cohesive gender-based etiology of Alzheimer disease

scientific article published on 18 October 2006

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents.

scientific article

Hypothalamic-pituitary-gonadal axis involvement in learning and memory and Alzheimer's disease: more than "just" estrogen

scientific article

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

scientific article published on 8 December 2011

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

scientific article published on 22 January 2007

Increases in luteinizing hormone are associated with declines in cognitive performance.

scientific article published on 6 February 2007

Indices of metabolic dysfunction and oxidative stress

scientific article published on 7 March 2007

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

scientific article published on 23 December 2009

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

scientific article

La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer

Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells

scientific article published on 25 March 2009

Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells

scientific article published on 16 September 2008

Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease

scientific article

Leptin: a novel therapeutic strategy for Alzheimer's disease

scientific article

Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss

scientific article published on 24 September 2018

Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice

scientific article published on 13 February 2006

Luteinizing hormone: Evidence for direct action in the CNS

scientific article published on 11 July 2015

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications.

scientific article published on 15 December 2017

Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease

scientific article

Menopause, estrogen, and gonadotropins in Alzheimer's disease

scientific article published on January 2008

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

scientific article published in May 2013

Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats

scientific article

Neurogenesis in Alzheimer’s Disease

Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis

Neuronal leptin resistance in Alzheimer's disease

scholarly article by David Bonda et al published July 2013 in Alzheimer's and Dementia

Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition

scientific article published on 01 January 2018

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms

scientific article published on 01 January 2019

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

scientific article

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.

scientific article

Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

article

Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

scientific article

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative imbalance in Alzheimer's disease

scientific article

Oxidative stress and redox-active iron in Alzheimer's disease

scientific article published on March 2004

Oxidative stress signalling in Alzheimer's disease

scientific article published on March 2004

Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer's Disease

scientific article

Perspectives on the amyloid-beta cascade hypothesis

scientific article published on April 2004

Pet-1 is required across different stages of life to regulate serotonergic function.

scientific article

Presenilin mutations impair mitochondrial dynamics in neurons

Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit. ⬇️

scientific article published on 5 February 2013

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

scientific article published on January 2008

Signal transduction cascades associated with oxidative stress in Alzheimer's disease

scientific article published on May 2007

Special issue on estrogen actions in the brain

scientific article published on 01 October 2010

Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease

scientific article

Targeting gonadotropins: an alternative option for Alzheimer disease treatment

scientific article

The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia

scientific article published on 06 September 2019

The Key Role of Oxidative Stress in Alzheimer's Disease

scholarly article published 2007

The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target

scientific article

The cell cycle in Alzheimer disease: a unique target for neuropharmacology

scientific article

The contribution of luteinizing hormone to Alzheimer disease pathogenesis

scientific article

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

scientific article

The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease

scientific article

The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

scientific article published on 22 January 2009

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

scientific article

The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease

scientific article

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

scientific article

Thinking Outside the Box in Alzheimer Disease Treatment

Transgenic Mouse Models of Alzheimer's Disease

article

Treatment advances in Alzheimer's disease based on the oxidative stress model

scientific article

Vascular oxidative stress in Alzheimer disease

scientific article

c-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments

scientific article published on 03 December 2019

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