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List of works by Brian Leber

A Canadian consensus on the management of newly diagnosed and relapsed acute promyelocytic leukemia in adults

scientific article

A Review of Pneumatosis Intestinalis in the Setting of Systemic Cancer Treatments, Including Tyrosine Kinase Inhibitors ⬇️

scientific article published on 07 March 2012

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

scientific article published on 05 April 2017

A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia

scientific article published on 01 August 2018

A predictive model of response to erythropoietin stimulating agents in myelodysplastic syndrome: from the Canadian MDS patient registry

scientific article published on 3 October 2017

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

scientific article published on 16 October 2017

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

scientific article published on 27 January 2020

An MDS-specific frailty index based on cumulative deficits adds independent prognostic information to clinical prognostic scoring

scientific article published on 06 December 2019

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

scientific article published on 12 March 2019

Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations ⬇️

scientific article published on June 2015

Cyclic thrombocytopenia with statistically significant neutrophil oscillations.

scientific article published on 31 May 2018

Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib

scientific article

Evidence-based guidelines for the use of tyrosine kinase inhibitors in adults with Philadelphia chromosome-positive or BCR-ABL-positive acute lymphoblastic leukemia: a Canadian consensus

scientific article published on April 2014

Evolving Therapeutic Options for Polycythemia Vera: Perspectives of the Canadian Myeloproliferative Neoplasms Group

scientific article published on 7 August 2015

Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy

scientific article published on 01 January 2014

Fornix fibers and motivational states as controllers of behavior: a study stimulated by the contextual retrieval theory

scientific article published on April 1, 1978

Hand Mirror Cells and Hypercalcemia: A Rare Presentation of Pediatric Acute Lymphoblastic Leukemia

scientific article published on 01 April 2020

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells

scientific article published on 13 June 2016

How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry

scientific article published on 25 October 2018

ITACA: A new validated international erythropoietic stimulating agent-response score that further refines the predictive power of previous scoring systems

scientific article

Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence

scientific article published on 01 September 2018

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells ⬇️

scientific article published on May 24, 2012

Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature.

scientific article

Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS

article

Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells.

scientific article

Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group

scientific article published on October 2016

Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia.

scientific article

Mixed variant multicentric Castleman disease treated with rituximab: case report

scientific article published on 01 November 2010

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond

scientific article published on 02 April 2015

Molecular genetic basis for the antiidiotypic antibody response associated with successful renal allograft survival in humans

scientific article published on February 1, 1991

Morphology of acute promyelocytic leukemia with cytogenetic or molecular evidence for the diagnosis: Characterization of additional microgranular variants ⬇️

scientific article published on 01 November 1997

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

scientific article published on 5 June 2014

Optimizing outcomes with azacitidine: recommendations from Canadian centres of excellence.

scientific article published on February 2014

Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient-related factors and measuring from time of first red blood cell transfusion dependence: an MDS-CAN analysis.

scientific article

PML/RARα APL with undifferentiated morphology and stem cell immunophenotype ⬇️

scientific article published on 01 September 1998

Patient-related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS-CAN prospective study.

scientific article published on 15 March 2016

Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O(6) -methylguanine DNA methyltransferase expression

scientific article published on 27 August 2014

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

scientific article

Randomized phase II comparison of standard CHOP with weekly CHOP in elderly patients with non-Hodgkin's lymphoma ⬇️

scientific article published on 01 September 1995

Regulating cell death at, on, and in membranes.

scientific article

Retinoic acid modulation of induced basophil differentiation ⬇️

scientific article published on December 1, 1997

Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatm

scientific article published on 30 July 2019

Sam68 Allows Selective Targeting of Human Cancer Stem Cells

scientific article published on 21 June 2017

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

scientific article published on 19 July 2010

Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results.

scientific article published on 3 August 2017

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

scientific article published on 24 January 2020

The predictive value of intracellular imatinib levels in newly diagnosed chronic myeloid leukemia

scientific article published on 05 December 2019

The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers.

scientific article published on May 2014

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

scientific article

Treatment of older patients with acute myeloid leukemia (AML): revised Canadian consensus guidelines

scientific article published on 25 July 2017

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove

scientific article published on 01 December 2018

cml biology for the clinician in 2011: six impossible things to believe before breakfast on the way to cure.

scientific article

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