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List of works by Gregory D Sempowski

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

scientific article published on 30 July 2020

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution

scientific article published on 01 January 2002

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination

scientific article

Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses

scientific article

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

scientific article

Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model

scientific article

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis

scientific article

Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis

scientific article published in August 2017

Association of age-dependent liver injury and fibrosis with immune cell populations

scientific article

Bayesian Multi-Plate High-Throughput Screening of Compounds.

scientific article published on 22 June 2018

Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice

scientific article

Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation

scientific article published on 01 August 2002

CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis

scientific article published in January 2004

Changes in primary lymphoid organs with aging

scientific article

Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels ⬇️

scientific article published on September 1, 1992

Cold sensitivity of the SARS-CoV-2 spike ectodomain

scientific article published on 13 July 2020

Cold sensitivity of the SARS-CoV-2 spike ectodomain

scholarly article by Robert J Edwards published in February 2021

Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases

scientific article

Cytokine Requirements for Induction of Systemic and Mucosal CTL After Nasal Immunization ⬇️

scientific article published on 01 November 2001

Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization

scientific article

Cytokines, leptin, and stress-induced thymic atrophy

scientific article published on 21 May 2008

Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA.

scientific article published on April 2015

Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice

scientific article published on 13 March 2013

Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response

scientific article published on 23 March 2015

Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays

scientific article

Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis

scientific article

Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts ⬇️

scientific article published on 01 September 1995

Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma

scientific article published on 01 January 2005

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

scientific article

Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation

scientific article published on November 2007

Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice

scientific article published in October 2003

Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates

scientific article (publication date: 2010)

Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation

scientific article published on 19 February 2004

Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea

scientific article published on 14 October 2013

Histone deacetylation critically determines T cell subset radiosensitivity

scientific article

Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection

scientific article

Human Thyroid Fibroblasts Exhibit a Distinctive Phenotype in Culture: Characteristic Ganglioside Profile and Functional CD40 Expression* ⬇️

scientific article published on 01 December 1997

Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production ⬇️

scientific article published on March 1, 1998

IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection

scientific article

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection

scientific article published on 01 April 2020

Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages

scientific article published on 27 September 2013

Identification of early interactions between Francisella and the host

scientific article

Immune reconstitution in patients with HIV infection

scientific article

Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation

scientific article

Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface

scientific article published on 23 January 2016

Immunologic characterization of CD7-deficient mice ⬇️

scientific article published on June 15, 1998

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort

scientific article published on 28 September 2018

Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis

scientific article

Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47).

scientific article published in November 2007

Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response

scientific article published on 25 March 2013

Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism

scientific article

Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis

scientific article

Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation

scientific article published on 8 June 2010

Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function

scientific article

Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques

Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution

scientific article published on 08 July 2009

Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy

scientific article

Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy

scientific article published in November 2002

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

scientific article

Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites

scientific article published on 02 December 2016

Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation

scientific article published on 21 January 2011

Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production

scientific article published on 15 February 2012

Measurement of mouse T cell receptor excision circles

scientific article published in November 2004

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires

scientific article published in January 2018

Modified Vaccinia Ankara Virus Vaccination Provides Long-Term Protection against Nasal Rabbitpox Virus Challenge

scientific article published on 04 May 2016

Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques

scientific article

Molecular measurement of T cell receptor excision circles

scientific article published in January 2013

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

scientific article published on 01 October 2020

Murine CD7 shares antigenic cross-reactivity with HSP-60.

scientific article

MyD88 provides a protective role in long-term radiation-induced lung injury

scientific article published on 6 February 2012

Naïve T Cells Are Maintained in the Periphery During the First3 Months of Acute HIV-1 Infection: Implications for Analysis of Thymus Function

article

Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation

scientific article

Neonates support "homeostatic" proliferation

scientific article published on 01 January 2002

Neonates support lymphopenia-induced proliferation.

scientific article

Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy

scientific article published in January 2002

Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19

scientific article published on 27 May 2020

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

scientific article

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

scientific article published on 18 September 2017

Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection

scientific article

Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status

scientific article published on January 2016

Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome

scientific article published on 20 April 2004

Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation

scientific article

Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation

scientific article

Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control

scientific article

Protection from death in endotoxin shock: does fish oil need a LIF?

scientific article published on 01 May 2002

Radiation combined with thermal injury induces immature myeloid cells

scientific article published on November 2012

Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan

scientific article published on 30 November 2017

Radiation- and Age-Associated Changes in Peripheral Blood Dendritic Cell Populations among Aging Atomic Bomb Survivors in Japan

scientific article published in January 2018

Regulation of T cell function by microRNA-720.

scientific article published on 22 July 2015

Regulation of steady-state neutrophil homeostasis by macrophages.

scientific article

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

scientific article published on 21 November 2020

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model

scientific article published on 24 August 2015

Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.

scientific article

Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen

scientific article

T cell receptor excision circle assessment of thymopoiesis in aging mice

scientific article published on 01 March 2002

TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB

scientific article

The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid

scientific article published on 18 May 2014

The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome

scientific article published on 11 December 2017

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

scientific article

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae

scientific article published on 08 December 2020

Thymic involution and immune reconstitution.

scientific article published on 18 June 2009

Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras

scientific article published on 11 May 2009

Thymic rejuvenation and aging

scientific article published on 04 July 2013

Thymopoietic and bone marrow response to murine Pneumocystis pneumonia

scientific article

Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients

scientific article

Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor

scientific article published on 26 September 2014

Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease

scientific article published on 9 October 2003

Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses

scientific article

Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury

scientific article

VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression

scientific article published on 13 February 2003

Validation of an Animal Isolation Imaging Chamber for Use in Animal Biosafety Level-3 Containment

scientific article

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

scientific article

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