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List of works by Robin Shattock

A "prime-pull" vaccine strategy has a modest effect on local and systemic antibody responses to HIV gp140 in mice

scientific article

A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

scientific article published on 22 February 2017

A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance

scientific article published on 28 April 2016

A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens

scientific article

A Plea for Justice for Jailed Medical Workers

scientific article published in Science

A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system

scientific article published on 19 January 2018

A novel strategy for inducing enhanced mucosal HIV-1 antibody responses in an anti-inflammatory environment

scientific article

A recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions

scientific article published in May 2007

AIDS models: microbicides could learn from vaccines

scientific article published on 01 May 2002

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

scientific article

Aggregate complexes of HIV-1 induced by multimeric antibodies

scientific article

Animal Models for Microbicide Studies ⬇️

scientific article published on January 1, 2012

Antibody responses after intravaginal immunisation with trimeric HIV-1 CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation

scientific article

Antigenicity and immunogenicity of HIV-1 gp140 with different combinations of glycan mutation and V1/V2 region or V3 crown deletion

scientific article published on 26 September 2019

Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission

scientific article published on January 2008

Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors

scientific article published on 14 November 2011

Assessment of mucosal immunity to HIV-1.

scientific article published on April 2010

Bifunctional CD4–DC-SIGN Fusion Proteins Demonstrate Enhanced Avidity to gp120 and Inhibit HIV-1 Infection and Dissemination ⬇️

scientific article published on June 11, 2012

Big is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

scientific article published on 08 April 2020

Binding of HIV-1 virions to α4β 7 expressing cells and impact of antagonizing α4β 7 on HIV-1 infection of primary CD4+ T cells

scientific article published on 10 December 2014

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study

scientific article published on 17 May 2008

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue

scientific article

Brief Report: Pharmacokinetic/Pharmacodynamic Investigation of Single-Dose Oral Maraviroc in the Context of HIV-1 Pre-exposure Prophylaxis

scientific article published on 13 June 2016

Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies

scientific article published on 19 October 2016

C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors ⬇️

scientific article published on September 1, 2010

CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue

scientific article published on 15 July 2013

CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic

scientific article published on 18 March 2009

Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model

scientific article published on 23 April 2008

Candidate microbicides and their mechanisms of action

scientific article published on January 2014

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants.

scientific article

Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

scientific article published on 19 February 2014

Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen.

scientific article

Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates

scientific article published on May 2006

Chemokine receptor expression and modulation by Mycobacterium tuberculosis antigens on mononuclear cells from human lymphoid tissues

scientific article published on 01 June 2006

Chemokine-Adjuvanted Plasmid DNA Induces Homing of Antigen-Specific and Non-Antigen-Specific B and T Cells to the Intestinal and Genital Mucosae

scientific article published on 08 January 2020

Chemokine/cytokine production by mononuclear cells from human lymphoid tissues and their modulation by Mycobacterium tuberculosis antigens

scientific article published on 01 March 2007

Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants

scientific article published on 01 October 2011

Combinations of TLR4 and TLR7/8 Adjuvants Administered via the ID or IN Routes Generate Different Vaccine Antigen-specific Immune Outcomes in Minipigs

Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study

scientific article

Correction: Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference

scientific article

Corrigendum: Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination.

scientific article

Critical issues in mucosal immunity for HIV-1 vaccine development

scientific article

Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models

scientific article published in January 2004

Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models

scientific article

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

scientific article

Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection

article

Design, expression, and characterization of a multivalent, combination HIV microbicide.

scientific article published on 26 May 2009

Discrete partitioning of HIV-1 Env forms revealed by viral capture.

scientific article

Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.

scientific article published on 29 October 2015

Dynamic electrophoretic fingerprinting of the HIV-1 envelope glycoprotein ⬇️

scientific article published on March 20, 2013

Effect of vaginal immunization with HIVgp140 and HSP70 on HIV-1 replication and innate and T cell adaptive immunity in women.

scientific article

Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA

scientific article published on 06 May 2019

Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture

scientific article published on 10 December 2018

Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture

scientific article published on 01 July 2019

Enhanced immunogenicity of an HIV-1 DNA vaccine delivered with electroporation via combined intramuscular and intradermal routes

scientific article

Envelope-Specific Recognition Patterns of HIV Vaccine-Induced IgG Antibodies Are Linked to Immunogen Structure and Sequence

article

Evaluation of TLR Agonists as Potential Mucosal Adjuvants for HIV gp140 and Tetanus Toxoid in Mice ⬇️

scientific article published on December 13, 2012

Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques

scientific article published on December 2015

Ex Vivo Evaluation of Mucosal Responses to Vaccination with ALVAC and AIDSVAX of Non-Human Primates

scientific article published on 25 January 2022

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides

scientific article published in June 2006

Expressing anti-HIV VRC01 antibody using the murine IgG1 secretion signal in Pichia pastoris.

scientific article published on 24 March 2017

Expression Profile of Human Fc Receptors in Mucosal Tissue: Implications for Antibody-Dependent Cellular Effector Functions Targeting HIV-1 Transmission.

scientific article

Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions

scientific article published on 19 April 2017

Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages

scientific article published on 21 December 2011

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

scientific article

Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen

scientific article published in 2014

HIV vaccine research in Canada

scientific article published on 12 September 2017

HIV-1 CNS in vitro infectivity models based on clinical CSF samples

scientific article published on 15 October 2015

HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo

scientific article

HIV-1 infection of human penile explant tissue and protection by candidate microbicides

scientific article

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.

scientific article published on June 2007

HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial

scientific article published on 29 June 2015

Herpes Simplex Virus Type 2 Infection of Human Epithelial Cells Induces CXCL9 Expression and CD4+ T Cell Migration via Activation of p38-CCAAT/Enhancer-Binding Protein-β Pathway ⬇️

scientific article published on May 14, 2012

Heterogeneous Conformation of HIV-1 Envelopes on Individual Virions.

scientific article published in October 2014

High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization

scientific article

Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction ⬇️

scientific article published on December 20, 2011

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

scientific article

Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection

scientific article published on 08 July 2009

IFN-gamma at the site of infection determines rate of clearance of infection in cryptococcal meningitis

scientific article published on 01 February 2005

Identification of potential biomarkers of vaccine inflammation in mice.

scientific article published on 14 May 2019

Immune Activation in the Female Genital Tract: Expression Profiles of Soluble Proteins in Women at High Risk for HIV Infection

scientific article published on 27 January 2016

Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

scientific article published on 20 December 2017

Improving defences at the portal of HIV entry: mucosal and innate immunity

scientific article

In vitro and in vivo: the story of nonoxynol 9.

scientific article

In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate.

scientific article published on 9 April 2007

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories

scientific article

Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans

scientific article published on 16 April 2019

Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.

scientific article published on 9 June 2015

Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections

scientific article

Inhibiting sexual transmission of HIV-1 infection

scientific article published on October 2003

Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.

scientific article

Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways.

scientific article

Innate immunity against HIV: a priority target for HIV prevention research

scientific article

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

scientific article published on 12 July 2019

Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis

scientific article

Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies

scientific article published on 26 October 2015

Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms

scientific article

Isolation and Characterization of Antigen-Specific Plasmablasts Using a Novel Flow Cytometry-Based Ig Capture Assay.

scientific article published on 8 November 2017

Localized cyclical variations in immunoproteins in the female genital tract and the implications on the design and assessment of mucosal infection and therapies

scientific article

Mannosylated poly(ethylene imine) copolymers enhance saRNA uptake and expression in human skin explants

scientific article published on 06 April 2020

Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates.

scientific article

Microbicide development: multiple targets, multiple mechanisms

scientific article published on 21 December 2006

Microbicide-vaccine Combination Provides Significant Protection against Vaginal SHIV-162P3 Challenge in Cynomolgous Monkeys

scholarly article by Roger Le Grand et al published October 2014 in AIDS Research and Human Retroviruses

Microbicides 2006 conference.

scientific article

Microbicides--aids to safer sex

scientific article published on 01 March 2004

Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations.

scientific article published on 07 August 2012

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

scientific article (publication date: 2012)

Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.

scientific article published on March 2014

Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans.

scientific article published on 26 February 2018

Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form.

scientific article published on 21 February 2012

Molecular umbrellas: a novel class of candidate topical microbicides to prevent human immunodeficiency virus and herpes simplex virus infections

scientific article published on 9 May 2007

Mucosal Tissue Tropism and Dissemination of HIV-1 Subtype B Acute Envelope-Expressing Chimeric Virus ⬇️

scientific article published on November 7, 2012

Mucosal application of gp140 encoding DNA polyplexes to different tissues results in altered immunological outcomes in mice.

scientific article

Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis

scientific article published on 02 September 2009

Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes

scientific article published on 01 December 2007

Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challenge

scientific article published on 21 August 2013

Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.

scientific article published on 12 August 2011

Novel Approaches to Vaginal Delivery and Safety of Microbicides: Biopharmaceuticals, Nanoparticles, and Vaccines ⬇️

scientific article published on December 1, 2010

Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses.

scientific article published on 5 October 2017

PRO-2000, an antimicrobial gel for the potential prevention of HIV infection.

scientific article published on February 2008

Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

scientific article published on 21 April 2022

Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway

scientific article published on 19 October 2006

Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application

scientific article published on 30 December 2013

Phase I randomised clinical trial of an HIV-1(CN54), clade C, trimeric envelope vaccine candidate delivered vaginally

scientific article

Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice

scientific article

Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines

scientific article published on 20 March 2014

Potential use of protease inhibitors as vaginal and colorectal microbicides

scientific article

Preclinical evaluation of lime juice as a topical microbicide candidate

scientific article

Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicide

scientific article

Preventing HIV-1 sexual transmission--not sexy enough science, or no benefit to the bottom line?

scientific article published on 12 November 2003

Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel

scientific article

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.

scientific article published on 10 February 2003

Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion

scientific article

Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection

scientific article published on 14 June 2013

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

article

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference

scientific article published on 26 July 2010

Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011.

scientific article published on 11 July 2012

Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010.

scientific article published on 12 April 2011

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin ⬇️

scientific article published on June 29, 2011

Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization

scientific article published in July 2005

Reverse transcriptase inhibitors as potential colorectal microbicides

scientific article published on 02 March 2009

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

scientific article published on 23 January 2016

Role of capsule and interleukin-6 in long-term immune control of Cryptococcus neoformans infection by specifically activated human peripheral blood mononuclear cells.

scientific article published on September 2006

Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

scientific article published on 12 August 2019

Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in prevention

scientific article

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

scientific article

Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?

scientific article

Selective transmission of R5 HIV-1 variants: where is the gatekeeper?

scientific article

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

scientific article published on 09 July 2020

Shaping the science of prevention

scientific article published on 01 January 2014

Short Communication: Limited Anti-HIV-1 Activity of Maraviroc in Mucosal Tissues

scientific article published on 29 December 2015

Structural Components for Amplification of Positive and Negative Strand VEEV Splitzicons.

scientific article published on 26 July 2018

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

scientific article published on 29 May 2019

Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates

scientific article published on 23 March 2016

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

scientific article

TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

scientific article

Target cells in vaginal HIV transmission

scientific article

Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses ⬇️

scientific article published on May 7, 2011

Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins

scientific article

The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

scientific article published on 27 August 2018

The Safety and Immunogenicity of GTU®MultiHIV DNA Vaccine Delivered by Transcutaneous and Intramuscular Injection With or Without Electroporation in HIV-1 Positive Subjects on Suppressive ART

scientific article published on 13 December 2019

The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

scientific article published on 03 May 2019

The complex challenges of HIV vaccine development require renewed and expanded global commitment

scientific article published on 02 December 2019

The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells

scientific article

The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling.

scientific article

Therapeutic role of CD8+ T cells in HIV-1 infection: targets and suppressors of viral replication

scientific article

Thymic stromal lymphopoietin (TSLP) acts as a potent mucosal adjuvant for HIV-1 gp140 vaccination in mice

scientific article

Transgenic plant production of Cyanovirin-N, an HIV microbicide.

scientific article published on 14 December 2005

Transporters for Antiretroviral Drugs in Colorectal CD4+ T Cells and Circulating α4β7 Integrin CD4+ T Cells: Implications for HIV Microbicides.

scientific article published on 28 July 2016

Turning the Tide Against HIV

scientific article

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

article published in the Proceedings of the National Academy of Sciences of the United States of America

Vaccine adjuvants: a priority for vaccine research

scientific article published on 9 January 2010

Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates

scientific article published on 27 May 2015

Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses

scientific article

Vaginal microbicides: moving ahead after an unexpected setback

scientific article

Vaginal microbicides: the importance of effective distribution, retention and coating of the mucosa

scientific article published in June 2008

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

scientific article

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