List of works - Hiroaki Shime

A rapid and simple PCR method for identifying isolates of the genus Azospirillum within populations of rhizosphere bacteria

scientific article published on 08 September 2011

Adjuvant for vaccine immunotherapy of cancer--focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity

scientific article

Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy

scientific article published on 04 April 2019

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

scientific article published on 18 February 2015

Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells

scientific article

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

scientific article published on 11 November 2016

Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice

scientific article published on 15 February 2019

Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.

scientific article

Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.

scientific article

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

scientific article

Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

scientific article published on 07 August 2020

Reply to Slominski et al.: UVB irradiation induces proenkephalin<sup>+</sup> regulatory T cells with a wound-healing function

scientific article published on 01 January 2021

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.

scientific article published on 5 September 2016

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages. ⬇️

scientific article published on 23 January 2017

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.

scientific article published on 17 October 2017

Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

scientific article published on 21 September 2017

Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model.

scientific article published on 21 February 2018

Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

scientific article

Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.

scientific article

Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin

scientific article published on 20 November 2017

Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.

scientific article published on 16 June 2018

List of works by Hiroaki Shime

A rapid and simple PCR method for identifying isolates of the genus Azospirillum within populations of rhizosphere bacteria

Adjuvant for vaccine immunotherapy of cancer--focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity

Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice

Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.

Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

Reply to Slominski et al.: UVB irradiation induces proenkephalin<sup>+</sup> regulatory T cells with a wound-healing function

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages. ⬇️

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.

Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model.

Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide.

Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin

Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.