List of works by Fabian Schumacher

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

scientific article published on 15 April 2019

1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.

scientific article published on 21 September 2010

A photocaged inhibitor of acid sphingomyelinase

scientific article published on 12 November 2020

A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells

scientific article published on 24 October 2013

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease ⬇️

scientific article published on 11 December 2019

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

scientific article published on 12 March 2020

Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity

scientific article published on 22 August 2019

Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide

scientific article published on 23 July 2018

Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

scientific article

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

scientific article published on 10 March 2020

Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects

scientific article published on 01 January 2019

Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin

scientific article published on 21 February 2019

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels

scientific article published on 05 August 2019

Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.

scientific article

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins

scientific article published on 06 July 2018

Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels

scientific article published on 11 December 2017

Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake

scientific article published on 27 February 2019

Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium.

scientific article published on 8 February 2017

Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice

scientific article published on 13 September 2015

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

scientific article published on 03 May 2020

In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.

scientific article

Interleukin-22 protects intestinal stem cells against genotoxic stress

scientific article published on 30 January 2019

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

scientific article published on 19 June 2019

Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium

scientific article published on 05 June 2019

Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry

scientific article published on 03 September 2014

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

scientific article published on 01 October 2019

Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells

scientific article published on 03 June 2021

Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.

scientific article published on 9 November 2012

Pathological manifestations of Farber disease in a new mouse model

scientific article published on 01 September 2018

Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration

scientific article published on 15 May 2019

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis

scientific article published on 15 October 2019

Serine Protease-Mediated Cutaneous Inflammation: Characterization of an Ex Vivo Skin Model for the Assessment of Dexamethasone-Loaded Core Multishell-Nanocarriers

scientific article published on 10 September 2020

Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS

scientific article

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

scientific article published on 2 January 2018

Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.

scientific article published in 2022

Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia

scientific article published on 20 June 2019

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

scientific article published on 01 September 2018

The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury

scientific article published on 03 July 2019

The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells

scientific article published on 13 March 2024

The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.

scientific article published on 9 February 2015

Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro

scientific article published on 01 October 2019

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice

scientific article published on 29 October 2018

Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

scientific article published on 17 September 2019

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor in colon cancer cells

scientific article published on 28 August 2018

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