Search filters

List of works by John P O'Bryan

Akt2 Stabilizes ATP7A, a Copper Transporter for SOD3 (Extracellular Superoxide Dismutase), in Vascular Smooth Muscles: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus

scientific article published on 4 January 2018

Bimolecular Fluorescence Complementation ⬇️

scientific article published on April 15, 2011

Cardiac-Specific Expression of the Tetracycline Transactivator Confers Increased Heart Function and Survival Following Ischemia Reperfusion Injury ⬇️

scientific article published on January 17, 2012

Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.

scientific article published on 16 September 2016

Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.

scientific article

Correction: Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

scientific article published on 01 May 2019

Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells ⬇️

scientific article published on 01 June 1998

Direct inhibition of RAS: Quest for the Holy Grail?

scientific article published on 14 December 2017

Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits.

scientific article published on 30 August 2013

Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways

scientific article

Inhibition of RAS function through targeting an allosteric regulatory site.

scientific article published on 7 November 2016

Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction ⬇️

scientific article published on December 12, 2011

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

scientific article published in October 2011

Intersectin scaffold proteins and their role in cell signaling and endocytosis.

scientific article

Pharmacological targeting of RAS: Recent success with direct inhibitors

scientific article published on 23 October 2018

Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis

scientific article

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

scientific article published on 23 March 2015

Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.

scientific article

Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice

scientific article published on 4 August 2017

Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

scientific article published on 20 December 2018

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.

scientific article

The Src Homology 2 and Phosphotyrosine Binding Domains of the ShcC Adaptor Protein Function as Inhibitors of Mitogenic Signaling by the Epidermal Growth Factor Receptor ⬇️

scientific article published on August 7, 1998

Therapeutic targeting of RAS: New hope for drugging the "undruggable"

scientific article published on 31 October 2019

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

scientific article

Paulina is supported by:

About Paulina

Help