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List of works by Matthew Freeman

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

scientific article

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

scientific article published in July 2000

A fly's eye view of EGF receptor signalling

scientific article

A genome-wide association study in mice reveals a role for Rhbdf2 in skeletal homeostasis

scientific article published on 24 February 2020

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration

scientific article published on 26 July 2020

Bacterial rhomboid proteases mediate quality control of orphan membrane proteins

scientific article published on 27 April 2020

Complexity of EGF receptor signalling revealed in Drosophila ⬇️

scientific article published on August 1, 1998

Control of ADAM17 activity by regulation of its cellular localisation

scientific article published on 12 October 2016

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

scientific article

Dual role of myosin II during Drosophila imaginal disc metamorphosis

scientific article

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

scientific article published on 13 June 2018

Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases

scientific article

Functional unknomics: Systematic screening of conserved genes of unknown function

scientific article published on 8 August 2023

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.

scientific article published on 13 November 2014

Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development ⬇️

scientific article published on October 1, 1992

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.

scientific article

Intramembrane proteolysis by rhomboids: catalytic mechanisms and regulatory principles.

scientific article published on 09 August 2013

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

scientific article

Live imaging of Drosophila imaginal disc development

scientific article

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

scientific article

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

scientific article published on 23 August 2013

Matthew Freeman: the sharp end of rhomboids

scientific article published on April 2014

Mechanism of G1 arrest in the Drosophila eye imaginal disc.

scientific article

Mechanism-based traps enable protease and hydrolase substrate discovery

scientific article published on 16 February 2022

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

scientific article

Modulation of Drosophila retinal epithelial integrity by the adhesion proteins capricious and tartan

scientific article

Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases

scientific article

Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation

scientific article published on 15 August 2018

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.

scientific article published on 11 July 2012

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

scientific article

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

scientific article published on 4 August 2017

Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila ⬇️

scientific article published on October 19, 2001

Regulation of receptor tyrosine kinase ligand processing

scientific article published on January 2014

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16.

scientific article published on 27 January 2017

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

scientific article

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

scientific article published on 06 June 2016

Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase

scholarly article

Rhomboid proteases and their biological functions

scientific article

Rhomboid proteases in human disease: Mechanisms and future prospects.

scientific article

Rhomboids, signalling and cell biology

scientific article

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates

scientific article

Sharpening rhomboid specificity by dimerisation and allostery

scientific article

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4

scientific article published on 07 June 2019

Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity

scientific article

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

scientific article

Substrates and physiological functions of secretase rhomboid proteases

scientific article

The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.

scientific article

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

scientific article published on 01 March 2019

The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.

scientific article published in July 2000

The rhomboid-like superfamily: molecular mechanisms and biological roles

scientific article

The structural basis for catalysis and substrate specificity of a rhomboid protease

scientific article

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

scientific article

Wherefore DMM?

scientific article published in July 2008

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction

scientific article published on 8 February 2018

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