List of works - Hidehisa Shimizu

A novel strategy for selective gene delivery by using the inhibitory effect of blue light on jetPRIME-mediated transfection.

scientific article

Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone.

scientific article published on 16 March 2015

Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon

scientific article published on 16 April 2014

CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.

scientific article published on 13 February 2013

Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

scientific article published in August 2016

Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF α-induced vascular endothelial cell dysfunction through NO production with subsequent NFκB inactivation.

scientific article published on 27 August 2013

Comparison of pro-adipogenic effects between prostaglandin (PG) D and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD, during the maturation phase of cultured adipocytes

scientific article published on 26 October 2018

Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet

scientific article published on 15 January 2020

Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.

scientific article

Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation.

scientific article

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

scientific article published on 18 September 2014

Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation.

scientific article

Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.

scientific article

Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.

scientific article published on 25 January 2013

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats

scientific article published on 21 May 2013

Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells

scientific article published on 31 December 2014

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

scientific article published on 28 November 2012

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.

scientific article

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats ⬇️

scientific article published on August 4, 2010

Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.

scientific article published on 6 March 2014

Influence of AHRR Pro189Ala polymorphism on kidney functions.

scientific article published on 20 February 2017

Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet

scientific article published on 26 March 2019

Megalo-type α-1,6-glucosaccharides induce production of tumor necrosis factor α in primary macrophages via toll-like receptor 4 signaling.

scientific article published in January 2016

Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.

scientific article

Protein tyrosine phosphatase PTPεM negatively regulates PDGF β-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells ⬇️

scientific article published on August 4, 2010

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

scientific article published on 08 February 2019

Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence

scientific article published on 08 August 2012

Thermal stability and bioavailability of inclusion complexes of perilla oil with γ-cyclodextrin

scientific article published on 25 April 2019

List of works by Hidehisa Shimizu

A novel strategy for selective gene delivery by using the inhibitory effect of blue light on jetPRIME-mediated transfection.

Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone.

Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon

CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.

Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF α-induced vascular endothelial cell dysfunction through NO production with subsequent NFκB inactivation.

Comparison of pro-adipogenic effects between prostaglandin (PG) D and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD, during the maturation phase of cultured adipocytes

Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet

Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.

Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation.

Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.

Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats

Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats ⬇️

Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.

Influence of AHRR Pro189Ala polymorphism on kidney functions.

Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet

Megalo-type α-1,6-glucosaccharides induce production of tumor necrosis factor α in primary macrophages via toll-like receptor 4 signaling.

Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.

Protein tyrosine phosphatase PTPεM negatively regulates PDGF β-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells ⬇️

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence

Thermal stability and bioavailability of inclusion complexes of perilla oil with γ-cyclodextrin