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List of works by Hideaki Oikawa

Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis

scientific article

An anti-tetraamination of a 1,3-diene unit via cascade annulations of the azulenone scaffold with dicarbonyl azo-compounds

scientific article published on 15 March 2010

An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation ⬇️

scientific article published in December 2005

Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences

scientific article published on 18 July 2019

Biogenetically inspired synthesis and skeletal diversification of indole alkaloids.

scientific article published on 24 November 2013

Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis

scientific article

Biosynthesis of indole diterpenes, emindole, and paxilline: involvement of a common intermediate

scientific article published on 01 August 2004

Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene

scientific article

Biosynthetic Machinery of 6-Hydroxymellein Derivatives Leading to Cyclohelminthols and Palmaenones

scientific article published on 18 October 2019

Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.

scientific article published on 19 September 2017

Biosynthetic gene-based secondary metabolite screening: a new diterpene, methyl phomopsenonate, from the fungus Phomopsis amygdali.

scientific article published in February 2009

Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part

scientific article published on 01 September 2006

Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase

article

Characterization of a rice gene family encoding type-A diterpene cyclases

scientific article

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

scientific article published on 16 August 2018

Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.

scientific article

Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus ⬇️

scientific article

Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis

scientific article

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes

scientific article published on 8 March 2017

Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants

scientific article published on 01 December 2018

Design and De Novo Synthesis of 6-Aza-artemisinins

scientific article published on 23 July 2018

Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice ⬇️

scientific article

Divergent and expeditious access to fused skeletons inspired by indole alkaloids and transtaganolides.

scientific article

Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

scientific article

Efficient Reconstitution of Basidiomycota Diterpene Erinacine Gene Cluster in Ascomycota Host Aspergillus oryzae Based on Genomic DNA Sequences

scientific article published on 24 September 2019

Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi

scientific article published on 21 May 2019

Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit

scientific article published on 26 April 2018

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis

scientific article

Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis

scientific article published on 04 March 2011

Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs

scientific article published in August 2008

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

scientific article published on 19 August 2008

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product ⬇️

scientific article published on July 2009

Expression of Alternaria solani PKSF generates a set of complex reduced-type polyketides with different carbon-lengths and cyclization

scientific article published on 01 June 2006

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

scientific article published on 25 May 2020

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products

scientific article published on 29 November 2017

Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster

scientific article published on 24 March 2013

Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues

scientific article

Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases

scientific article published on 4 June 2021

Heterologous Biosynthesis of Fungal Indole Sesquiterpene Sespendole

scientific article published on 19 June 2018

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

scientific article published on 01 December 2018

Hg(OTf)(2)-catalyzed direct vinylation of tryptamines and versatile applications for tandem reactions

scientific article published on 23 April 2012

Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway

scientific article published on 01 October 2006

Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. ⬇️

scientific article published on 7 January 2009

Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali

scientific article

Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.

scientific article published on 10 February 2018

Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus

scientific article

Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture

scientific article published on January 2008

Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

scientific article (publication date: 13 March 2003)

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

scientific article published in May 2010

Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.

scientific article published on 24 November 2010

Molecular cloning and characterization of a cDNA encoding ent-cassa-12,15-diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension-cultured rice cells treated with a chitin elicitor

scientific article

Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin

scientific article published on 17 February 2020

Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization

scientific article

Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

scientific article published on 10 March 2012

Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

scientific article published on 11 August 2020

Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene.

scientific article published on 21 June 2005

Proposed mechanism for the reaction catalyzed by a diterpene cyclase, aphidicolan-16beta-ol synthase: experimental results on biomimetic cyclization and examination of the cyclization pathway by ab initio calculations

scientific article published on 01 August 2002

Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

scientific article

Recent advances of Diels-Alderases involved in natural product biosynthesis

scientific article published on 15 June 2016

Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem

article published in 2015

Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae

scientific article

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host.

scientific article published on 5 November 2015

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.

scientific article

Relative and absolute configuration of antitumor agent SW-163D.

scientific article published on 7 December 2007

Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.

scientific article published on 21 December 2006

Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis

scientific article published on 20 April 2012

Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D

scientific article published on 01 February 2009

Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani

scientific article

Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis

scientific article published on 6 January 2017

Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents

scientific article published on 7 March 2017

Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation

scientific article

Structure of macrophomate synthase.

scientific article

Studies on the later stage of the biosynthesis of pleuromutilin

scientific article published on 7 December 2007

The relative and absolute configuration of PF1140.

scientific article

Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification

scientific article published on 19 September 2018

Total biosynthesis of antiangiogenic agent (-)-terpestacin by artificial reconstitution of the biosynthetic machinery in Aspergillus oryzae

scientific article published on 8 February 2018

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

scientific article

Total synthesis of (+/-)-syn-copalol

scientific article

Total synthesis of alkaloids using both chemical and biochemical methods

scientific article published on 06 March 2020

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

scientific article published on 14 October 2008

Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase

scientific article published on 18 September 2018

Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds

scientific article published on 01 May 2019

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