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List of works by Christos J Petropoulos

A case-based reasoning system for genotypic prediction of HIV-1 co-receptor tropism

scientific article

A decade of HIV-1 drug resistance in the United States: trends and characteristics in a large protease/reverse transcriptase and co-receptor tropism database from 2003 to 2012.

scientific article

A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein

scientific article (publication date: 2011)

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

scientific article published in August 2003

A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue

scientific article published in March 2009

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

article

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

scientific article

Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection

scientific article

Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease

scientific article

Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication

scientific article

Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity

scientific article published in May 2002

Analysis of HIV-1 subtype B third variable region peptide motifs for induction of neutralizing antibodies against HIV-1 primary isolates

scientific article published on 20 October 2005

Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens ⬇️

scientific article published on June 28, 2010

Ancestral sequences from an elite neutralizer proximal to the development of neutralization resistance as a potential source of HIV vaccine immunogens

article

Assessing chemokine co-receptor usage in HIV

scientific article

Assessing predicted HIV-1 replicative capacity in a clinical setting

scientific article published in November 2011

Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women

scientific article published on 20 April 2006

Baseline HIV type 1 coreceptor tropism predicts disease progression

scientific article published on 20 July 2007

Broad Nucleoside Reverse‐Transcriptase Inhibitor Cross‐Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates ⬇️

scientific article published on September 16, 2003

Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope

scientific article

CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy

scientific article published on 17 January 2002

Cerebrospinal fluid HIV infection and pleocytosis: relation to systemic infection and antiretroviral treatment

scientific article

Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors

scientific article published on May 2004

Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B.

scientific article

Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals

scientific article

Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus

scientific article published in May 2003

Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance

scientific article

Comparison of human immunodeficiency virus type 1 tropism profiles in clinical samples by the Trofile and MT-2 assays

scientific article published on 17 August 2009

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

scientific article

Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens ⬇️

scientific article published on April 4, 2011

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus

scientific article

Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein

scientific article published on 19 March 2008

Coreceptor tropism in human immunodeficiency virus type 1 subtype D: high prevalence of CXCR4 tropism and heterogeneous composition of viral populations.

scientific article

Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing

scientific article

Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism

scientific article published on 20 November 2006

Development of an HIV-1 reference panel of subtype B envelope clones isolated from the plasma of recently infected individuals

scientific article published on 01 September 2007

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

scientific article

Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection

Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors

scientific article published on September 2010

Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein

scientific article

Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain

scientific article

Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1

scientific article published on 27 September 2016

Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.

scientific article

Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy

scientific article

Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults

scientific article published on November 2002

Exploring the complexity of the HIV-1 fitness landscape

scientific article

Five Antiretroviral Drug Class-Resistant HIV-1 in a Treatment-Naïve Patient Successfully Suppressed with Optimized Antiretroviral Drug Selection

scientific article published on 17 July 2015

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

scientific article

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer

scientific article published on August 2013

HIV drug resistance acquired through superinfection

scientific article

HIV evolution and escape.

scientific article

HIV-1 chemokine coreceptor utilization in paired cerebrospinal fluid and plasma samples: a survey of subjects with viremia

scientific article

Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection

scientific article

Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains

scientific article published on January 2005

Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates

scientific article published in October 2002

Identification of a transmission chain of HIV type 1 containing drug resistance-associated mutations

scientific article published in May 2003

Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption

scientific article

Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance

scientific article published in May 2003

In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine

scientific article

Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report

scientific article published in March 2005

Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection

scientific article published on 20 September 2005

Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure

scientific article

Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab ⬇️

scientific article published on February 2, 2011

Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways

scientific article published on 16 September 2009

Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies

scientific article published on 28 March 2007

Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease

scientific article published on 23 August 2018

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

scientific article published on November 2002

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations

scientific article published on March 2004

Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir

scientific article published on 03 June 2013

Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1.

scientific article

Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.

scientific article published on December 2004

Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses

scientific article

Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection

scientific article

Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data

scientific article

Persistence of drug-resistant HIV-1 after a structured treatment interruption and its impact on treatment response

scientific article

Persistence of primary drug resistance among recently HIV-1 infected adults

scientific article

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds

scientific article (publication date: March 2015)

Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

scientific article published on 19 March 2008

Phenotypic and genotypic HIV-1 drug resistance assays provide complementary information

scientific article published in October 2002

Phenotypic drug resistance patterns in subtype A HIV-1 clones with nonnucleoside reverse transcriptase resistance mutations

scientific article published on March 2006

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1.

scientific article

Practical applications of viral fitness in clinical practice

scientific article

Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method

scientific article

Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab

scientific article published on 24 October 2017

Principal component analysis of general patterns of HIV-1 replicative fitness in different drug environments.

scientific article published on 31 March 2010

Quantitation of HER2 expression or HER2:HER2 dimers and differential survival in a cohort of metastatic breast cancer patients carefully selected for trastuzumab treatment primarily by FISH.

scientific article published in March 2009

Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1

scientific article (publication date: June 2014)

Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines

scientific article

Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasma

scientific article published on November 2003

Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors

scientific article published on 03 September 2013

Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions

scientific article published in April 2002

Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.

scientific article published on 7 January 2004

Substitutions at Amino Acid Positions 143, 148, and 155 of HIV-1 Integrase Define Distinct Genetic Barriers to Raltegravir Resistance In Vivo ⬇️

scientific article published on May 2, 2012

Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition

scientific article published on 28 April 2008

The K101P and K103R/V179D mutations in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nonnucleoside reverse transcriptase inhibitors

scientific article published on January 2006

The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment ⬇️

scientific article published on October 4, 2011

The probable source of both the primary multidrug-resistant (MDR) HIV-1 strain found in a patient with rapid progression to AIDS and a second recombinant MDR strain found in a chronically HIV-1-infected patient

scientific article

Time trends in primary HIV-1 drug resistance among recently infected persons

scientific article

Transmission of Integrase Strand-Transfer Inhibitor Multidrug-Resistant HIV-1: Case Report and Response to Raltegravir-Containing Antiretroviral Therapy ⬇️

scientific article published on January 1, 2011

Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542.

scientific article published on February 2004

Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother-infant pairs.

scientific article published on September 2009

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

scientific article published on 22 February 2013

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