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List of works by Robert J Ferrante

A call for transparent reporting to optimize the predictive value of preclinical research

scientific article

A high-throughput screen to identify inhibitors of SOD1 transcription.

scientific article

A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease

scientific article

ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis ⬇️

scientific article published on December 22, 2011

Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis

scientific article published on 29 January 2009

Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice

scientific article (publication date: November 2004)

Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons

scientific article

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis

scientific article

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

scientific article

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

scientific article published on November 2004

Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS ⬇️

scientific article published on May 22, 2012

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

scientific article published in October 2005

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

scientific article

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice

scientific article published on 5 December 2005

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

scientific article

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

scientific article published in April 2009

Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide

scientific article published on 31 January 2007

Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS".

scientific article published on 24 February 2017

Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice

scientific article

Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells ⬇️

scientific article published on November 30, 2011

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation

scientific article published in October 2004

Cytochrome C and caspase-9 expression in Huntington's disease

scientific article

Depletion of wild-type huntingtin in mouse models of neurologic diseases

scientific article published in October 2003

Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice

scientific article published on 17 April 2006

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

scientific article

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

scientific article

Emerging chemotherapeutic strategies for Huntington's disease

scientific article

Evidence of oxidant damage in Huntington's disease: translational strategies using antioxidants

scientific article published on December 2008

Experimental Models of HD and Reflection on Therapeutic Strategies

scientific article published on January 1, 2011

Experimental therapeutics in transgenic mouse models of Huntington's disease

scientific article published on May 2004

Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage

scientific article

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice ⬇️

scientific article published on October 15, 2003

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

scholarly article

Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression

scientific article published in December 2002

Huntington's disease: progress and potential in the field

scientific article published on December 2007

Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis ⬇️

scientific article published on November 12, 2010

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

scientific article

Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease.

scientific article published in July 2003

Inhibition of mitochondrial protein import by mutant huntingtin

scientific article

Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease

scientific article

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition ⬇️

scientific article published on February 6, 2013

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis ⬇️

scientific article published on March 26, 2013

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

scientific journal article

Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid

scientific article published in July 2002

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

scientific article published on 20 August 2003

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

scientific article published in May 2002

Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival

scientific journal article

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

scientific article

Mitochondrial nuclear receptors and transcription factors: who's minding the cell?

scientific article published on April 2008

Modulation of nucleosome dynamics in Huntington's disease

scientific article

Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation

scientific article

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

scientific article

Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice

scientific article

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

scientific article

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

scientific article published on 19 October 2004

Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.

scientific article

Nortriptyline delays disease onset in models of chronic neurodegeneration

scientific article

Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis

article

Phase 2 study of sodium phenylbutyrate in ALS.

scientific article published in April 2009

Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice

scientific article (publication date: 30 June 2004)

Pyrimidine-2,4,6-trione Derivatives and Their Inhibition of Mutant SOD1-Dependent Protein Aggregation. Toward a Treatment for Amyotrophic Lateral Sclerosis ⬇️

scientific article published on March 4, 2011

Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease

scientific article

Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response

scientific article published on 28 September 2006

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition

scientific article

Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

scientific article

Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease ⬇️

scientific article published on December 1, 2003

Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

scientific article published in June 2005

Sp1 and Sp3 Are Oxidative Stress-Inducible, Antideath Transcription Factors in Cortical Neurons ⬇️

scientific article published on May 1, 2003

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

scientific article published on 4 April 2006

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity ⬇️

scientific article published on October 12, 2011

The neuroprotective role of creatine.

scientific article

The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models

scientific article published on 29 November 2012

The therapeutic role of creatine in Huntington's disease

scientific article

Therapeutic attenuation of mitochondrial dysfunction and oxidative stress in neurotoxin models of Parkinson's disease

scientific article

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

scientific article

Therapeutic effects of cystamine in a murine model of Huntington's disease.

scientific article published in October 2002

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse

scientific article

Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

scientific article published in July 2005

Translating therapies for Huntington's disease from genetic animal models to clinical trials

scientific article

Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

scholarly article

Translational therapeutic strategies in amyotrophic lateral sclerosis

scientific article published on February 2007

Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice

scientific article published on 22 June 2010

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