List of works - Carole A. Bewley

A Model of Peptide Triazole Entry Inhibitor Binding to HIV-1 gp120 and the Mechanism of Bridging Sheet Disruption ⬇️

scientific article published on March 22, 2013

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.

scientific article published on 3 April 2017

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 [...]

scientific article

Antimicrobial Chrysophaentin Analogs Identified from Laboratory Cultures of the Marine Microalga Chrysophaeum taylorii

scientific article published on 09 January 2019

Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa

scientific article published in May 2002

Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles.

scientific article published on 26 September 2016

Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations

scientific article

Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy.

scientific article published on October 2013

Chemical and Biophysical Approaches for Complete Characterization of Lectin-Carbohydrate Interactions.

scientific article published on 23 July 2017

Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

scientific article

Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria

scientific article published on 25 July 2013

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article published on 24 May 2016

Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis

scientific article

Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry

scientific article

Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.

scientific article published on 11 May 2017

Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR ⬇️

scientific article published on November 1, 1997

Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor ⬇️

scientific article published on January 5, 2012

Effective isotope labeling of proteins in a mammalian expression system.

scientific article

Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle

scientific article published on 23 November 2021

Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments.

scientific article

Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function.

scientific article published on 16 March 2015

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

scientific article (publication date: 24 October 2016)

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

scientific article

Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA.

scientific article

Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.

scientific article published on 6 February 2017

Lithistid Sponges: Star Performers or Hosts to the Stars

scientific article published on 01 September 1998

Mammalian expression of isotopically labeled proteins for NMR spectroscopy

scientific article published on January 2012

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.

scientific article

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

scientific article published on 9 November 2016

Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

scientific article

Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa ⬇️

scientific article

Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships

scientific article

NMR spectroscopy of HIV-1 gp120 outer domain.

scientific article published on 13 September 2012

Natural products: Tapping into personalized chemistry.

scientific article published in January 2018

Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.

scientific article published on 11 July 2016

Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site.

scientific article published in October 2014

Solution Conformations of Mycothiol Bimane, 1-d-GlcNAc-α- (1 → 1)-d-myo-Ins and 1-d-GlcNAc-α-(1 → 1)-l-myo-Ins ⬇️

scientific article published on May 2, 2003

Solution structure of cyanovirin-N, a potent HIV-inactivating protein

scientific article published on July 1, 1998

Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

scientific article

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

scientific article

Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition.

scientific article published on 13 September 2012

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

scientific article

Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors ⬇️

scientific article published on February 17, 2011

Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.

scientific article

Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis

scientific article published on 08 September 2020

Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry ⬇️

scientific article published on October 21, 2010

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article

The Structure of U17 Isolated from Streptomyces clavuligerus and its Properties as an Antioxidant Thiol ⬇️

scientific article published on June 1, 1995

The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

scientific article published on August 1, 1997

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

scientific article

Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge

scientific article published on 24 August 2017

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

scientific article

Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL.

scientific article

X-ray Crystallography and Unexpected Chiroptical Properties Reassign the Configuration of Haliclonadiamine

scientific article published on 30 January 2020

List of works by Carole A. Bewley

A Model of Peptide Triazole Entry Inhibitor Binding to HIV-1 gp120 and the Mechanism of Bridging Sheet Disruption ⬇️

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 [...]

Antimicrobial Chrysophaentin Analogs Identified from Laboratory Cultures of the Marine Microalga Chrysophaeum taylorii

Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa

Binding Site Geometry and Subdomain Valency Control Effects of Neutralizing Lectins on HIV-1 Viral Particles.

Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations

Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy.

Chemical and Biophysical Approaches for Complete Characterization of Lectin-Carbohydrate Interactions.

Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

Cyanovirin-N inhibits mannose-dependent Mycobacterium-C-type lectin interactions but does not protect against murine tuberculosis

Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry

Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.

Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR ⬇️

Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor ⬇️

Effective isotope labeling of proteins in a mammalian expression system.

Genome-Guided Discovery of Natural Products through Multiplexed Low-Coverage Whole-Genome Sequencing of Soil Actinomycetes on Oxford Nanopore Flongle

Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments.

Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function.

Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA.

Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.

Lithistid Sponges: Star Performers or Hosts to the Stars

Mammalian expression of isotopically labeled proteins for NMR spectroscopy

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa ⬇️

Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships

NMR spectroscopy of HIV-1 gp120 outer domain.

Natural products: Tapping into personalized chemistry.

Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.

Potent SIV-specific Antibodies Targeting the Cyanovirin Binding Site.

Solution Conformations of Mycothiol Bimane, 1-d-GlcNAc-α- (1 → 1)-d-myo-Ins and 1-d-GlcNAc-α-(1 → 1)-l-myo-Ins ⬇️

Solution structure of cyanovirin-N, a potent HIV-inactivating protein

Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors ⬇️

Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors.

Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis

Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry ⬇️

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

The Structure of U17 Isolated from Streptomyces clavuligerus and its Properties as an Antioxidant Thiol ⬇️

The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL.

X-ray Crystallography and Unexpected Chiroptical Properties Reassign the Configuration of Haliclonadiamine