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List of works by Young Kee Shin

A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

scientific article published on 01 January 2018

A mutated recombinant subunit vaccine protects mice and guinea pigs against botulinum type A intoxication.

scientific article published on 15 November 2017

A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2- early breast cancer.

scientific article published on 28 March 2017

A novel mutation in the linker domain of the signal transducer and activator of transcription 3 gene, p.Lys531Glu, in hyper-IgE syndrome

scientific article

A novel staphylococcal enterotoxin B subunit vaccine candidate elicits protective immune response in a mouse model

scientific article published on 27 March 2017

A prognostic model for lymph node-negative breast cancer patients based on the integration of proliferation and immunity.

scientific article published on 11 June 2011

Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas

scientific article

Abstract 1356: GENOCTC, a highly efficient system for enrichment of circulating tumor cells and its clinical application

scholarly article

An Immune-Magnetophoretic Device for the Selective and Precise Enrichment of Circulating Tumor Cells from Whole Blood

scientific article published on 30 May 2020

An immunohistochemical study of the expression of adhesion molecules in gallbladder lesions

scientific article published in May 2004

An improved protocol of biotinylated tyramine-based immunohistochemistry minimizing nonspecific background staining

scientific article

Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia.

scientific article

Author Correction: Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients

scientific article published on 07 February 2020

BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer

scientific article published in PLoS ONE

Basal buffer systems for a newly glycosylated recombinant human interferon-β with biophysical stability and DoE approaches

scientific article published on 25 July 2015

CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer.

scientific article

CD24+ ovary cancer cells exhibit an invasive mesenchymal phenotype ⬇️

scientific article published on February 8, 2013

Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis ⬇️

scientific article published on March 31, 2011

Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing

scholarly article

Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.

scientific article

Clinical significance of CD99 down-regulation in gastric adenocarcinoma

scientific article published on May 2007

Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2 , a novel paralog of human CD99, and identification of evolutionary conserved motifs ⬇️

scientific article published on March 27, 2003

Combining multiple microarrays in the presence of controlling variables

scientific article published on 16 May 2006

Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples

scientific article published on 7 December 2015

Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer

scientific article published on 24 July 2019

Correction: Identification of Novel Reference Genes Using Multiplatform Expression Data and Their Validation for Quantitative Gene Expression Analysis.

scientific article published on 7 August 2009

Correction: triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival.

scientific article published on 12 January 2011

Cross-Protective Whole-Cell Vaccine With a Truncated O-Polysaccharide Chain

scientific article published on 31 October 2018

Cytoplasmic CD24 expression in advanced ovarian serous borderline tumors

scientific article published on 01 May 2005

Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications

scientific article

Design and synthesis of a macrosphelide A-biotin chimera

scientific article published on 01 September 2014

Detection of Merkel cell polyomavirus in Merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry.

scientific article

Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting

scientific article published on 28 December 2019

Development of an Equine Antitoxin by Immunizing the Halla Horse with the Receptor-Binding Domain of Botulinum Neurotoxin Type A1

scientific article published on 01 July 2019

Development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative.

scientific article published on 29 September 2014

Droplet digital PCR-based EGFR mutation detection with an internal quality control index to determine the quality of DNA.

scientific article published on 11 January 2018

Dysregulation of miR-375/AEG-1 Axis by Human Papillomavirus 16/18-E6/E7 Promotes Cellular Proliferation, Migration, and Invasion in Cervical Cancer

scientific article published on 09 September 2019

ESRP1 is overexpressed in ovarian cancer and promotes switching from mesenchymal to epithelial phenotype in ovarian cancer cells

scientific article published on 9 October 2017

Economic Evaluation of Companion Diagnostic Testing for EGFR Mutations and First-Line Targeted Therapy in Advanced Non-Small Cell Lung Cancer Patients in South Korea

scientific article

Effect of HPV E6/E7 siRNA with Chemotherapeutic Agents on the Regulation of TP53/E2F Dynamic Behavior for Cell Fate Decisions

scientific article

Efficiency of methylated DNA immunoprecipitation bisulphite sequencing for whole-genome DNA methylation analysis.

scientific article

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines.

scientific article published on 8 October 2015

Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium

scientific article

Enhanced Cell Growth of Adipocyte-Derived Mesenchymal Stem Cells Using Chemically-Defined Serum-Free Media

scientific article

Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses

scientific article published on 22 July 2020

Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions

scientific article published on 16 June 2006

Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer ⬇️

scientific article published on January 31, 2011

Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis.

scientific article

Essential Role of DNA Methyltransferase 1-mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

scientific article published on 31 August 2016

Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients

scientific article published on 29 January 2008

Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.

scientific article published in May 2009

Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence

scientific article published in December 2008

Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancer

scientific article published on 21 September 2017

Girdin protein expression is associated with poor prognosis in patients with invasive breast cancer

scientific article published on 14 August 2017

Glycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic properties

scientific article (publication date: 2014)

Glycosylation Heterogeneity of Hyperglycosylated Recombinant Human Interferon-β (rhIFN-β)

scientific article published on 20 March 2020

HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors.

scientific article

High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients.

scientific article published in February 2012

High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy

scientific article published on 28 November 2019

High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma

scientific article published on July 15, 2013

Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes

scientific journal article

Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo

scientific article published on 29 May 2015

Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical Cancer

scientific article

Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response

scientific journal article

Identification of formaldehyde-responsive genes by suppression subtractive hybridization

scientific journal article

Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis

scientific article

Immunogenicity and biodistribution of anthrax DNA vaccine delivered by intradermal electroporation

scientific article published on 14 April 2020

Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression

scientific article published on January 2007

Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions

scientific article published on 01 May 2006

Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets

scientific article

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin

scientific article

Intradermal immunization with botulinum neurotoxin serotype E DNA vaccine induces humoral and cellular immunity and protects against lethal toxin challenge

scientific article published on 05 October 2018

Involvement of promyelocytic leukemia protein in the ethanol-induced apoptosis in mouse embryo fibroblasts

scientific article published in July 2008

LMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cells ⬇️

scientific article published on August 1, 2001

LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients.

scientific article published on 14 October 2016

LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer

scientific article

Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma

scientific article

Long non-coding RNAs in hematologic malignancies: road to translational research.

scientific article

Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview

scientific article published on 12 December 2018

Low SP1 expression differentially affects intestinal-type compared with diffuse-type gastric adenocarcinoma

scientific article

MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values.

scientific article published on 10 May 2017

MET is a potential target for use in combination therapy with EGFR inhibition in triple-negative/basal-like breast cancer.

scientific article published on May 2014

MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer.

scientific article

MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells.

scientific article published on 13 November 2017

Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c

scientific article published in April 2009

Merkel cell carcinoma: our experience with seven patients in Korea and a literature review

scientific article published on 05 March 2010

Molecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles

scientific article published on 18 July 2020

Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

scientific article published on 30 September 2014

Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.

scientific article

New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC

scientific article published on 03 February 2020

Overexpression of CD24: association with invasiveness in urothelial carcinoma of the bladder

scientific article published on February 2007

Overexpression of Cancer-Associated Genes via Epigenetic Derepression Mechanisms in Gynecologic Cancer

scientific article published on 4 February 2014

Overexpression of interleukin-10 in sentinel lymph node with breast cancer

scientific article published on 29 August 2007

Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage

scientific article published on 01 August 2019

Physostigmine-loaded liposomes for extended prophylaxis against nerve agent poisoning

scientific article published on 30 October 2018

Polyamidoamine-Decorated Nanodiamonds as a Hybrid Gene Delivery Vector and siRNA Structural Characterization at the Charged Interfaces.

scientific article published on 30 August 2017

Prognostic significance of CD151 overexpression in non-small cell lung cancer

scientific article published on 06 April 2013

RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse

scientific article published on 01 January 2021

Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region

scientific article published in July 2005

Regulation of Ovarian Cancer Stem Cells or Tumor-Initiating Cells ⬇️

scientific article published on March 25, 2013

Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity

scientific article published on 12 February 2006

Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets

scientific article published on 26 September 2006

Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target

scientific article published on 8 September 2009

SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner

scientific article

STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody

scientific article

Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy.

scientific article published on 10 January 2017

Solution structure of the cytoplasmic domain of human CD99 type I.

scientific article

Stability and Activity of the Hyperglycosylated Human Interferon-β R27T Variant

scientific article published on 21 May 2020

Synthesis and biological evaluation of a polyyne-containing sphingoid base probe as a chemical tool

scientific article published in August 2013

TM4SF4 and LRRK2 are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis

scientific article published on 16 September 2020

Targeted cytotoxic effect of anti-JL1 immunotoxin against a human leukemic cell line and its clinical implications

scientific article published on 27 May 2003

Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients

scientific article published on 27 June 2017

Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells

scientific article

The ATF6-EGF Pathway Mediates the Awakening of Slow-Cycling Chemoresistant Cells and Tumor Recurrence by Stimulating Tumor Angiogenesis

scientific article published on 02 July 2020

The clinical significance of serum N-terminal pro-brain natriuretic peptide in systemic sclerosis patients

scientific article published on 25 September 2007

The enhanced reactivity of endogenous biotin-like molecules by antigen retrieval procedures and signal amplification with tyramine.

scientific article

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR

scientific journal article

The interplay between slow-cycling, chemoresistant cancer cells and fibroblasts creates a proinflammatory niche for tumor progression

scientific article published on 19 March 2020

The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair

scientific article

The potential RNAi-based combination therapeutics ⬇️

scientific article published on January 1, 2011

The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis

scientific article published on 11 November 2015

The synergistic therapeutic effect of cisplatin with Human papillomavirus E6/E7 short interfering RNA on cervical cancer cell lines in vitro and in vivo

scientific article published on 8 August 2011

The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.

scientific article

Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer

scientific article published on 15 June 2020

Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling

scientific article published on 12 June 2012

Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective

scientific article

Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

scientific article

UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer

scientific article published on 01 January 2019

Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans.

scientific article published on 4 October 2017

Upregulation of SMAD4 by MZF1 inhibits migration of human gastric cancer cells.

scientific article published on 06 December 2016

Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients

scientific article published in Scientific Reports

[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin

scientific article published in April 2005

c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer

scholarly article

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