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List of works by Valérie de Crécy-Lagard

'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites

scientific article

'Unknown' proteins and 'orphan' enzymes: the missing half of the engineering parts list--and how to find it

scientific article

6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria

scientific article published on 24 April 2009

7-Deazaguanine modifications protect phage DNA from host restriction systems

scientific article published on 29 November 2019

A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism.

scientific article

A Gateway platform for functional genomics in Haloferax volcanii: deletion of three tRNA modification genes.

scientific article published on 12 February 2009

A genetic investigation of the KEOPS complex in halophilic Archaea

scientific article

A network approach to elucidate and prioritize microbial dark matter in microbial communities

scientific article published on 22 September 2020

A plastidial pantoate transporter with a potential role in pantothenate synthesis

scientific article published on 30 January 2018

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.

scientific article

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

scientific article

A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis

scientific article published on 20 July 2017

A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life

scientific article

Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering

scientific article published on 28 October 2004

Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code?

scientific article published in October 2004

Bacterial and plant HAD enzymes catalyse a missing phosphatase step in thiamin diphosphate biosynthesis

scientific article published on 4 November 2015

Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages

scientific article published in 2024

Biosynthesis and function of posttranscriptional modifications of transfer RNAs

scientific article published on 16 August 2012

Biosynthesis and function of tRNA modifications in Archaea

scientific article published on 04 April 2011

Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I

scientific article published on 17 October 2008

Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside

scientific journal article

Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea

scientific article published on 9 April 2010

Can Protein Expression Be Regulated by Modulation of tRNA Modification Profiles?

scientific article published on 18 December 2018

Comparative RNomics and modomics in Mollicutes: prediction of gene function and evolutionary implications

scientific article published on 01 October 2007

Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage

scientific article published on 26 September 2012

Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate

scientific article

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

scientific article

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme

scientific article

Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.

scientific article

Deciphering synonymous codons in the three domains of life: co-evolution with specific tRNA modification enzymes

scientific article published on January 2010

Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors

scientific article published in 2024

Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.

scientific article published on 08 December 2016

Decoding in Candidatus Riesia pediculicola, close to a minimal tRNA modification set?

scientific article published on January 2012

Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA

scientific article

Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs

scientific article

Discovery of a new prokaryotic type I GTP cyclohydrolase family.

scientific article

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight

scientific article

Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs

scientific journal article

Diversity of archaeosine synthesis in crenarchaeota

scientific article

Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA

scientific article

Epoxyqueuosine Reductase QueH in the Biosynthetic Pathway to tRNA Queuosine Is a Unique Metalloenzyme

scientific article published on 15 October 2021

Erratum to “Towards a Systems Approach in the Genetic Analysis of Archaea: Accelerating Mutant Construction and Phenotypic Analysis in Haloferax volcanii”.

scientific article

Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria

scientific article published on 04 September 2015

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

scientific article

Evolutionary Diversity of Dus2 Enzymes Reveals Novel Structural and Functional Features among Members of the RNA Dihydrouridine Synthases Family

scientific article published in 2022

Experimental Evolution of a Facultative Thermophile from a Mesophilic Ancestor ⬇️

scientific article published on October 21, 2011

Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB).

scientific article published on 31 March 2016

Finding novel metabolic genes through plant-prokaryote phylogenomics

scientific article published on 9 November 2007

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa

scientific journal article

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold

scientific article

Functional Annotations of Paralogs: A Blessing and a Curse

scientific article published on 08 September 2016

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

scientific article published on 12 June 2015

Functional promiscuity of the COG0720 family

scientific article published on 26 October 2011

Functional redundancy in tRNA dihydrouridylation

scientific article published in 2024

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

scientific article

Gene Graphics: a genomic neighborhood data visualization web application

scientific article

Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi

scientific article

Genome sequence of Candidatus Riesia pediculischaeffi, endosymbiont of chimpanzee lice, and genomic comparison of recently acquired endosymbionts from human and chimpanzee lice

scientific article

Genomics-driven reconstruction of acinetobacter NAD metabolism: insights for antibacterial target selection

scientific article

Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway

scientific article

Identification of a Novel Epoxyqueuosine Reductase Family by Comparative Genomics

scientific article

Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine

scientific article (publication date: 20 February 2004)

Identification of genes encoding tRNA modification enzymes by comparative genomics

scientific article

Identification of the minimal bacterial 2'-deoxy-7-amido-7-deazaguanine synthesis machinery

scientific article published on 12 October 2018

Identification of the tRNA-dihydrouridine synthase family.

scientific article

Identification of the thiamin salvage enzyme thiazole kinase in Arabidopsis and maize

scientific article published on 28 June 2013

Incorporation of nonnatural amino acids into proteins

scientific article published on January 2004

Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase

scientific article

Inhibition of mutation and combating the evolution of antibiotic resistance

scientific article

Integrative data-mining tools to link gene and function

scientific article

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

scientific article published on 18 February 2020

MODOMICS: a database of RNA modification pathways. 2017 update

scientific article published on 2 November 2017

Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress

scientific article published on 4 June 2014

Matching tRNA modifications in humans to their known and predicted enzymes

scientific article published on 18 March 2019

Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite

scientific article published on 13 June 2016

Metabolite Damage and Metabolite Damage Control in Plants

scientific article

Mining high-throughput experimental data to link gene and function

scientific article

Molecular determinants of dihydrouridine synthase activity.

scientific article

Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase

scientific article

Mutational separation of two pathways for editing by a class I tRNA synthetase.

scientific article published in February 2002

Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy

scientific article published on December 2016

PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis

scientific article published on 01 November 2019

Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.

scientific article

Plant B vitamin pathways and their compartmentation: a guide for the perplexed

scientific article published on 21 August 2012

Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family

scientific article

Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

scientific article published on 19 September 2008

Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species

scientific article

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species

scientific article

Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii

scientific article

Quantitative mapping of the cellular small RNA landscape with AQRNA-seq

scientific article published on 15 April 2021

QueF-Like, a Non-Homologous Archaeosine Synthase from the Crenarchaeota

scientific article

Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci

scientific article published on 30 November 2012

RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes

scientific article published on 09 October 2008

Rapid evolution of diminished transformability in Acinetobacter baylyi

scientific article

Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

scientific article published on 10 April 2020

Role of a Zn-independent DksA in Zn homeostasis and stringent response

scientific journal article

Structural Basis of Biological Nitrile Reduction

scientific article

Synergistic use of plant-prokaryote comparative genomics for functional annotations

scientific article

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes

scientific article

The COMBREX project: design, methodology, and initial results

scientific article

The DUF328 family member YaaA is a DNA-binding protein with a novel fold

scientific article published on 12 August 2020

The Escherichia coli COG1738 Member YhhQ Is Involved in 7-Cyanodeazaguanine (preQ₀) Transport

scientific article published on 08 February 2017

The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth

scientific article published on 10 June 2015

The absence of the Queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in <i>Escherichia coli</i> K12

scientific article published in 2022

The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA.

scientific article

The emerging role of complex modifications of tRNA(Lys)UUU in signaling pathways

scientific article published on January 2015

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes

scientific article

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

scientific article

Towards a systems approach in the genetic analysis of archaea: Accelerating mutant construction and phenotypic analysis in Haloferax volcanii

scientific article

Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex

scientific article published on 09 June 2020

Variations in metabolic pathways create challenges for automated metabolic reconstructions: Examples from the tetrahydrofolate synthesis pathway

scientific article

YeiR: a metal-binding GTPase from Escherichia coli involved in metal homeostasis

scientific article published on 17 April 2012

Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB

scientific article

tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy

scientific article published on 8 March 2017

tRNAmodpred: A computational method for predicting posttranscriptional modifications in tRNAs

scientific article published on 22 March 2016

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