List of works by Tamara Vanhaecke

(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substances

scientific article published on 2 February 2017

A simple dilute-and-shoot method for screening and simultaneous quantification of nicotine and alkaloid impurities in electronic cigarette refills (e-liquids) by UHPLC-DAD

scientific article published on 02 March 2019

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism

scientific article published on 21 December 2019

Assaying Cellular Viability Using the Neutral Red Uptake Assay.

scientific article

Assessment of stability, toxicity and immunogenicity of new polymeric nanoreactors for use in enzyme replacement therapy of MNGIE.

scientific article

Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death

scientific article

Biology and pathobiology of gap junctional channels in hepatocytes

scientific article published on March 2008

COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?

scientific article published on 08 April 2020

Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development

scientific article published on 29 August 2009

Characterization of hepatic markers in human Wharton's Jelly-derived mesenchymal stem cells

scientific article

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes.

scientific article

Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow

scientific article

Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response

scientific article published on 22 April 2010

Coatings in food contact materials: Potential source of genotoxic contaminants?

scientific article published on 02 June 2017

Comment to 'Letter to the editor: Human-based systems: Mechanistic NASH modelling just around the corner?'

scientific article published on 10 October 2018

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

scientific article

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

scientific article published on 8 April 2012

Connexin and pannexin (hemi)channels in the liver.

scientific article published on 10 January 2014

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

scientific article published on 4 December 2009

Connexin43 signaling contributes to spontaneous apoptosis in cultures of primary hepatocytes

scientific article published on 14 October 2011

Connexins and their channels in cell growth and cell death

scientific article

Connexins: sensors and regulators of cell cycling.

scientific article published on 27 August 2010

Critical selection of reliable reference genes for gene expression study in the HepaRG cell line

scientific article published on 15 March 2011

Current status of human adipose-derived stem cells: differentiation into hepatocyte-like cells

scientific article published on 16 August 2011

DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes

scientific journal article

Development and characterization of a new human hepatic cell line.

scientific article

Development and validation of a HS/GC-MS method for the simultaneous analysis of diacetyl and acetylpropionyl in electronic cigarette refills

scientific article published on 04 May 2017

Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?

scientific article

Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

scientific article published on 15 February 2008

Differential role of epigenetic modulators in malignant and normal stem cells: a novel tool in preclinical in vitro toxicology and clinical therapy

scientific article published on 27 March 2007

Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development

scientific article published on 04 April 2007

Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes.

scientific article

Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures

scientific article published in August 2004

Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes

scientific article published in January 2010

Effects of Trichostatin A on drug uptake transporters in primary rat hepatocyte cultures

scientific article published on 5 May 2015

Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH

scientific article published on 24 April 2019

Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology

scientific article published on October 2010

Epigenetic Modifications as Antidedifferentiation Strategy for Primary Hepatocytes in Culture

scientific article published on January 2015

Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?

scientific article published on 29 August 2008

Establishment of Sandwich Cultures of Primary Human Hepatocytes

scientific article published on 01 January 2019

Evaluation of a new standardized enzymatic isolation protocol for human umbilical cord-derived stem cells.

scientific article published on 23 December 2014

Evaluation of the multipotent character of human adipose tissue-derived stem cells isolated by Ficoll gradient centrifugation and red blood cell lysis treatment.

scientific article

Evaluation of the multipotent character of human foreskin-derived precursor cells

scientific article published on 22 March 2011

Exposure of HepaRG Cells to Sodium Saccharin Underpins the Importance of Including Non-Hepatotoxic Compounds When Investigating Toxicological Modes of Action Using Metabolomics

scientific article published on 04 November 2019

Functionality Testing of Primary Hepatocytes in Culture by Measuring Urea Synthesis.

scientific article published in January 2015

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

scientific article published on July 2009

Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples.

scientific article

Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5' Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis

scientific article published on 29 April 2020

Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone

scientific article published on 14 December 2017

Hepatocyte cultures in drug metabolism and toxicological research and testing

scientific article published on 01 January 2006

Hepatocytes in suspension

scientific article published on 01 January 2006

Human Skin-Derived Precursor Cells: Isolation, Expansion, and Hepatic Differentiation.

scientific article

Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

scientific article published on 01 July 2020

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

scientific article published on August 2014

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals

scientific article published on 21 September 2013

Human-based systems: Mechanistic NASH modelling just around the corner?

scientific article published on 30 June 2018

Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.

scientific article published on 24 October 2014

Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes

scientific article published on January 2015

Impact of the revised European Tobacco Product Directive on the quality of e-cigarette refill liquids in Belgium

scientific article published on 29 January 2020

In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

scientific article

In vitro assessment of hepatotoxicity by metabolomics: a review

scientific article published on 25 August 2018

In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art.

scientific article published on March 2009

Inflammation Alters the Secretome and Immunomodulatory Properties of Human Skin-Derived Precursor Cells

scientific article published on 08 April 2020

Inhibition of gap junctional intercellular communication by toxic metals.

scientific article published on 24 September 2010

Involvement of cell junctions in hepatocyte culture functionality

scientific article published on April 2006

Isolation of rat bone marrow stem cells

scientific article published on January 2006

Isolation of rat hepatocytes.

scientific article

Junctional structures and hepatocellular carcinoma: from the lab to the clinic?

scientific article

Measurement of Albumin Secretion as Functionality Test in Primary Hepatocyte Cultures

scientific article published on 01 January 2015

Measurement of Apoptotic and Necrotic Cell Death in Primary Hepatocyte Cultures

scientific article published in January 2015

Measurement of Cytochrome P450 Enzyme Induction and Inhibition in Human Hepatoma Cells.

scientific article published on January 2015

Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential.

scientific article

Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophen

scientific article

Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate.

scientific article published on 17 January 2018

MicroRNAs as key regulators of xenobiotic biotransformation and drug response.

scientific article

Modifications in connexin expression in liver development and cancer

scientific article published on August 2012

Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes

scientific journal article

Modulation of connexin signaling by bacterial pathogens and their toxins

scientific article published on 09 June 2011

Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures.

scientific article published on August 2006

Neuropeptide FF receptors as novel targets for limbic seizure attenuation

scientific article published on 9 May 2015

New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test

scientific article published on 29 April 2020

Non-channel functions of connexins in cell growth and cell death

scientific article published on 22 June 2011

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

article

Opinion of the Scientific Committee on Consumer Safety (SCCS)--The safety of the use of formaldehyde in nail hardeners

scientific article published on 27 March 2015

Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

scientific article published on 05 December 2011

Optimisation of in vitro sample preparation for LC-MS metabolomics applications on HepaRG cell cultures

article

Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation

scientific article published on 22 December 2020

Performance of in silico models for mutagenicity prediction of food contact materials.

scientific article published on 20 March 2018

Polymeric nanoreactors for enzyme replacement therapy of MNGIE.

scientific article published on November 2010

Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor

scientific article published on 12 October 2010

Primary hepatocyte cultures as in vitro tools for toxicity testing: quo vadis?

scientific article published on 12 January 2012

Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.

scientific article published on February 2013

Primary hepatocytes and their cultures in liver apoptosis research

scientific article

Printed paper and board food contact materials as a potential source of food contamination

scientific article published on 05 July 2016

Prioritizing substances of genotoxic concern for in-depth safety evaluation using non-animal approaches: The example of food contact materials

scientific article published on 28 November 2018

Proliferation of epidermal growth factor-stimulated hepatocytes in a hormonally defined serum-free medium.

scientific article published in June 2004

Proliferative and phenotypical characteristics of human adipose tissue-derived stem cells: comparison of Ficoll gradient centrifugation and red blood cell lysis buffer treatment purification methods

scientific article published on 22 July 2014

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures

scientific article published on 7 December 2012

Protocols in In Vitro Hepatocyte Research. Preface

scientific article published on January 2015

Purinergic signalling during sterile liver injury

scientific article

Rat Hepatocyte Cultures : Collagen Gel Sandwich and Immobilization Cultures

scientific article published in January 2006

Rat Hepatocyte Cultures : Conventional Monolayer and Cocultures With Rat Liver Epithelial Cells

scientific article published in January 2006

Rat hepatocyte cultures: collagen gel sandwich and immobilization cultures

scientific article published on 01 January 2006

Rat hepatocyte cultures: conventional monolayer and cocultures with rat liver epithelial cells

scientific article published on 01 January 2006

Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors

scientific article published on 01 June 2004

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury

scientific article published on 10 March 2020

Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation.

scientific article published on 02 April 2009

Safeguarding human health using in silico tools?

scientific article

Safety evaluation of traces of nickel and chrome in cosmetics: The case of Dead Sea mud

scientific article published on 22 October 2015

Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors

scientific article published on 30 September 2008

Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019

scientific article published on 24 August 2020

Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients

scientific article

Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells

Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool?

scientific article published on 22 April 2011

Spontaneous apoptosis, necrosis, energy status, glutathione levels and biotransformation capacities of isolated rat hepatocytes in suspension: effect of the incubation medium

scientific article published in June 2005

Strategies for immortalization of primary hepatocytes

scientific article

Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes

scientific article published on 29 March 2011

Tailored liquid chromatography-mass spectrometry analysis improves the coverage of the intracellular metabolome of HepaRG cells.

scientific article published on 23 January 2017

Technological advancements for the development of stem cell-based models for hepatotoxicity testing

scientific article published on 29 April 2019

Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?

scientific article published on 28 May 2014

The Impact of Cell-Expansion and Inflammation on The Immune-Biology of Human Adipose Tissue-Derived Mesenchymal Stromal Cells

scientific article published on 04 March 2020

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

scientific article published on 26 April 2008

The novel histone deacetylase inhibitor 4-Me2N-BAVAH differentially affects cell junctions between primary hepatocytes

scientific article published on 07 April 2007

The pharmaceutical potential of histone deacetylase inhibitors

scientific article

The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings

scientific article published on 28 February 2020

Towards an integrated in vitro strategy for repeated dose toxicity testing

scientific article published on 22 April 2011

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.

scientific article published on 20 October 2015

Toxicological and metabolic considerations for histone deacetylase inhibitors

scientific article published on 04 January 2013

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

scientific article published on 7 February 2013

Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor

scientific article published on 03 June 2019

Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes

scientific article published in September 2003

Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes

scientific article published on 25 October 2006

Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view

scientific article

Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes

scientific article published on 10 March 2006

Untargeted liquid chromatography-mass spectrometry metabolomics to assess drug-induced cholestatic features in HepaRG® cells

scientific article published on 16 July 2019

Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?

scientific article published on 2 October 2013

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