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List of works by Karen Reue

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

scientific article

A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism

scientific article published on June 2017

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

scientific article published in May 2018

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man ⬇️

scientific article published on September 15, 2011

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13

scientific journal article

A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2

scientific journal article

ABCC6 localizes to the mitochondria-associated membrane

scientific article

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

scientific article

Adaptive thermogenesis in white adipose tissue: is lactate the new brown(ing)?

scientific article

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

scientific article published on March 2013

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models

scientific article published on 05 January 2009

Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.

scientific article

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

scientific journal article

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium

scientific journal article

Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.

scientific article

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

scientific article published on 25 February 2013

Approaches to lipid metabolism gene identification and characterization in the postgenomic era.

scientific article published on 11 July 2006

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

scientific article published on 5 April 2017

Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

scientific article published on 31 March 2009

Biphasic expression of lipin suggests dual roles in adipocyte development

scientific article

Cell nuclei spin in the absence of lamin b1.

scientific article

Cell-autonomous sex determination outside of the gonad

scientific article (publication date: April 2013)

Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

scientific article published on 15 August 2003

Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice

scientific article

Coupling energy homeostasis with a mechanism to support plasticity in brain trauma

scientific article

Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism

scientific article

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

scientific article published on 5 October 2011

Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

scientific article

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels

scientific journal article

Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis

scientific article published on 27 May 2015

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants

scientific article published on 2 January 2018

Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis.

scientific article

Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

scientific article

Follistatin promotes adipocyte differentiation, browning, and energy metabolism

scientific article

GPIHBP1, an endothelial cell transporter for lipoprotein lipase ⬇️

scientific article published on August 15, 2011

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

article

Genetic Basis for Sex Differences in Obesity and Lipid Metabolism

scientific article

Genetic factors in type 2 diabetes: all in the (lipin) family

scientific article published on 01 December 2007

Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically

scientific article published on 2 February 2008

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle

scientific article published on 30 December 2013

Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.

scientific article

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

scientific journal article

Hoofbeats, zebras, and insights into insulin resistance

scientific article

How lipid droplets "TAG" along: Glycerolipid synthetic enzymes and lipid storage

scientific article

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

scientific article

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

scientific article published on 8 December 2017

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.

scientific article

Increased high-density lipoprotein cholesterol levels in mice with XX versus XY sex chromosomes

scientific article

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

scientific article published on 09 September 2009

Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes

scientific article

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

scientific article published on 17 January 2018

Lamin B1 is required for mouse development and nuclear integrity

scientific article

Lamins A and C but not lamin B1 regulate nuclear mechanics.

scientific article

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

scientific article published on 10 December 2015

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

scientific article published on 03 December 2018

Lipin deficiency impairs diurnal metabolic fuel switching.

scientific article published in December 2006

Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation

scientific article

Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.

scientific article published on 29 April 2004

Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond

scientific article

Lipin proteins and metabolic homeostasis.

scientific article published on 21 October 2008

Lipin, a lipodystrophy and obesity gene

scientific article

Lipin-1 Phosphatidic Phosphatase Activity Modulates Phosphatidate Levels to Promote Peroxisome Proliferator-activated Receptor γ (PPARγ) Gene Expression during Adipogenesis ⬇️

scientific article published on December 6, 2011

Lipin-1 and lipin-3 together determine adiposity in vivo

scientific article

Lipin-1 flexes its muscle in autophagy

scientific article published in January 2014

Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle

scientific article

Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling

scientific article

Lipins: multifunctional lipid metabolism proteins

scientific article published on August 2010

Metabolic consequences of lipodystrophy in mouse models.

scientific article published on July 2006

Metabolic differences in breast cancer stem cells and differentiated progeny

scientific article

Metabolic impact of sex chromosomes

scientific article published on April 2013

Metabolic state of glioma stem cells and nontumorigenic cells

scientific article

Metabolic syndrome: from epidemiology to systems biology

scientific article

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

scientific article published on 23 December 2017

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

scientific article

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

scientific journal article

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection ⬇️

scientific article published on October 14, 2010

NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway

scientific article

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

scientific article

PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response

scientific article published on 3 August 2013

Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

scientific article

Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases

scientific article

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs

scientific article published on 13 February 2017

Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.

scientific article published on 15 December 2011

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

scientific article

Regulation of bile acid homeostasis by the intestinal Diet1-FGF15/19 axis

scientific article published in April 2014

Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis

scientific article published on 24 March 2008

Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt

scientific article

Response to Pomozi et al's research commentary

scientific article published on 26 April 2013

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

scientific article published on 18 December 2015

Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases

scientific article published on 9 March 2017

Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes

scientific article

Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities

scientific article published on 8 March 2017

Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism

scientific article published on 28 September 2016

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

scientific article

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

scientific article published on April 2016

StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria

scientific article published on 30 September 2016

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

scientific article published on 7 April 2013

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

scientific article

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism

scientific article published on 26 October 2001

The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries

scientific article published on 10 April 2014

The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance ⬇️

scientific article

The importance of having two X chromosomes

scientific article published on February 2016

The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.

scientific article published on 3 September 2008

The lipin family: mutations and metabolism

scientific article published on June 2009

The lipin protein family: dual roles in lipid biosynthesis and gene expression

scientific article

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

scientific article

The number of x chromosomes causes sex differences in adiposity in mice

scientific article

The role of lipin 1 in adipogenesis and lipid metabolism

scientific article published on 01 January 2007

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

scientific article published on May 2007

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

scientific article

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

scientific article

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

scientific article published on April 2016

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.

scientific article published on 15 November 2011

Ulcerative dermatitis in C57BL/6 mice exhibits an oxidative stress response consistent with normal wound healing ⬇️

scientific article published on June 1, 2012

Women in Metabolism: Part 3.

scientific article published in December 2015

X and Y chromosome complement influence adiposity and metabolism in mice

scientific article published on 8 February 2013

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