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List of works by Reinhard Guthke

4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence ⬇️

scientific article published on February 4, 2012

A mathematical model of microbial growth including an intermediate. I. Growth in batch cultures

scientific article published on January 1, 1977

A review on computational systems biology of pathogen-host interactions

scientific article

A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease

scientific article

Adapted Boolean network models for extracellular matrix formation.

scientific article

Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri

scientific article

An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells

scientific article published on 12 March 2012

Analysis and simulation of complex interactions during dynamic microfiltration of Escherichia coli suspensions

scientific article published on 01 July 1998

Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus

scientific article

Batch correction of microarray data substantially improves the identification of genes differentially expressed in Rheumatoid Arthritis and Osteoarthritis ⬇️

scientific article published on June 8, 2012

Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study

scientific article

Bistability in a model of microbial product formation

scientific article published in January 1980

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

scientific article

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

scientific article

Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.

scientific article published on 10 January 2016

Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy

scientific article published on 29 January 2019

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

scientific article

Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression

scientific article

Computational prediction of molecular pathogen-host interactions based on dual transcriptome data

scientific article

Computing the various pathways of penicillin synthesis and their molar yields

scientific article published on July 2015

Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq

scientific article

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

scientific article published on 28 July 2016

Convergence of the proteomic pattern in cancer

scientific article published on 7 March 2006

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

scientific article published on 08 April 2014

Data and knowledge based experimental design for fermentation process optimization

scientific article

Data- and knowledge-based modeling of gene regulatory networks: an update

scientific article

Data-based Reconstruction of Gene Regulatory Networks of Fungal Pathogens

scientific article

Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.

scientific article

DeltaMS: a tool to track isotopologues in GC- and LC-MS data

scientific article published on 27 February 2018

Dietary L-carnitine alters gene expression in skeletal muscle of piglets

article

Differential Biphasic Transcriptional Host Response Associated with Coevolution of Hemagglutinin Quasispecies of Influenza A Virus

scientific article

Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells

scientific article published on 3 January 2018

Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus

scientific article

Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum

scientific article published on 22 January 2015

Draft Genome Sequence of Streptomyces iranensis. ⬇️

scientific article published on 17 July 2014

Draft Genome Sequence of the Fungus Penicillium brasilianum MG11

scientific article published on 3 September 2015

Draft Genome Sequences of Fungus Aspergillus calidoustus

scientific article

Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417.

scientific article published on 22 January 2015

Dynamic model of discontinuous and continuous phaseolotoxin production of Pseudomonas syringae pv. phaseolicola.

scientific article published in January 1984

Dynamic model of the pathogenesis of Mengo virus infection in mice

scientific article published on August 1987

Dynamic modelling of microRNA regulation during mesenchymal stem cell differentiation

scientific article

Dynamic network reconstruction from gene expression data applied to immune response during bacterial infection

scientific article

Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

scientific article published on 21 March 2006

Editorial: Computational Systems Biology of Pathogen-Host Interactions

scientific article published on 04 February 2016

Effect of L-carnitine on the hepatic transcript profile in piglets as animal model ⬇️

scientific article published on October 31, 2011

Efficiency of the cyclic batch antibiotic fermentation

scientific article published in October 1982

Erratum: Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment ⬇️

scientific article published on March 29, 2011

Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network

scientific article

Facing the challenges of multiscale modelling of bacterial and fungal pathogen-host interactions

scientific article published on 08 February 2016

FungiFun2: a comprehensive online resource for systematic analysis of gene lists from fungal species

scientific article

FungiFun: A web-based application for functional categorization of fungal genes and proteins ⬇️

scientific article published on November 10, 2010

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes

scientific article

Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules.

scientific article published on July 2005

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

scientific article published on 23 June 2016

Gene regulatory network inference: data integration in dynamic models-a review

scientific article

Genome-Wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis

scientific article published on 21 March 2016

Genome-Wide Scale-Free Network Inference for Candida albicans ⬇️

scientific article published on February 16, 2012

Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior

scientific article published on 22 February 2017

Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression.

scientific article

Global epithelial cell transcriptional responses reveal Streptococcus pyogenes Fas regulator activity association with bacterial aggressiveness.

scientific article published on September 2005

Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue.

scientific article published on 14 May 2009

High-cell-density cultivation of microorganisms

scientific article

Hormetic effect of rotenone in primary human fibroblasts

scientific article

How to Predict Molecular Interactions between Species?

scientific article

Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane.

scientific article published on 22 August 2008

Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation

scientific article

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

scientific article published on April 2012

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

scientific article published on 3 March 2018

In silico evidence for gluconeogenesis from fatty acids in humans

scientific article published in July 2011

Increased Expression of RUNX1 in Liver Correlates with NASH Activity Score in Patients with Non-Alcoholic Steatohepatitis (NASH)

scientific article published on 18 October 2019

Inference of Predictive Phospho-regulatory Networks from LC-MS/MS Phosphoproteomics Data

Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0 ⬇️

scientific article published on January 2, 2013

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

scientific article published on 09 January 2020

Influence of steroid hormones on pS2/BCEI gene expression in xenografted colon tumors.

scientific article published on September 1993

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

scientific article published on 12 May 2014

Integrative analysis of the heat shock response in Aspergillus fumigatus

scientific article

Integrative inference of gene-regulatory networks in Escherichia coli using information theoretic concepts and sequence analysis ⬇️

scientific article

Integrative modeling of transcriptional regulation in response to antirheumatic therapy

scientific article published on 24 August 2009

Interactive exploration of integrated biological datasets using context-sensitive workflows

scientific article published on 20 February 2014

Knowledge-based assessment of gene expression data from chemiluminescence detection

scientific article

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan.

scientific article published on 24 February 2016

MS characterization of apheresis samples from rheumatoid arthritis patients for the improvement of immunoadsorption therapy - a pilot study

scientific article published on 01 July 2009

Mass spectrometric and peptide chip epitope analysis on the RA33 autoantigen with sera from rheumatoid arthritis patients.

scientific article

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant

scientific article (publication date: December 2014)

Missing values in gel-based proteomics

scientific article

Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

scientific article published on 06 May 2013

Model aided dynamic process analysis and optimization for the nourseothricin fermentation ⬇️

scientific article published on January 1, 1984

Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

scientific article published on 20 October 2018

ModuleDiscoverer: Identification of regulatory modules in protein-protein interaction networks

scientific article published on 11 January 2018

Molecular discrimination of responders and nonresponders to anti-TNF alpha therapy in rheumatoid arthritis by etanercept

scientific article published on 2 May 2008

Monitoring of transcriptome and proteome profiles to investigate the cellular response of E. coli towards recombinant protein expression under defined chemostat conditions

scientific article published on 4 March 2008

More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli

scientific article

Multiphasic growth of microorganisms: modeling and computer simulation of linear growth phases

scientific article published on 01 January 1978

Multivariate analysis of flow cytometric data using decision trees

scientific article

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus

scientific article

Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment

scientific article published on 19 October 2010

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

scientific article published on 14 February 2013

Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients

scientific article

On the way toward systems biology of Aspergillus fumigatus infection

scientific article published on 08 May 2011

Optimal regulatory strategies for metabolic pathways in Escherichia coli depending on protein costs.

scientific article published on 19 July 2011

Prediction of cardiovascular risk in hemodialysis patients by data mining

scientific article

Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus

scientific article

Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis

scientific article published on 14 March 2016

Proteomics of Aspergillus fumigatus conidia-containing phagolysosomes identifies processes governing immune evasion

scientific article

Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.

scientific article published on 31 May 2019

RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis

scientific article published on 25 July 2014

Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach ⬇️

scientific article published on January 19, 2012

Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells

scientific article

Regulatory networks controlling nitrogen sensing and uptake in Candida albicans

scientific article

Rheumatoid arthritis, a complex multifactorial disease: on the way toward individualized medicine

scientific article

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

scientific article

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts

scientific article

Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells

scientific article published on 23 February 2017

Sustained liver regeneration after portal vein embolization --a human molecular pilot study

scientific article published on 5 May 2012

Systems biology of microbial infection

scientific article published on 12 September 2012

The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes

scientific article

The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus

scientific article published on 7 July 2014

Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis

scientific article published on 01 February 2019

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

scientific article published on 26 October 2010

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

scientific article published on 30 January 2018

Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus

scientific article

Two-pool model analysis of data in hemodialysis by means of programmable pocket calculator TI 59.

scientific article

Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers

scientific article

Verticillium dahliae-Arabidopsis Interaction Causes Changes in Gene Expression Profiles and Jasmonate Levels on Different Time Scales

scientific article published on 13 February 2018

Within-host influenza dynamics: a small-scale mathematical modeling approach.

scientific article

Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake

scientific article published on August 2017

[Changes in the pharmacokinetics of gentamycin during nephrotoxic therapy]

scientific article published on 01 January 1988

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