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List of works by Timothy J Kieffer

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control

scientific article

A Role for Hepatic Leptin Signaling in Lipid Metabolism via Altered Very Low Density Lipoprotein Composition and Liver Lipase Activity in Mice ⬇️

scientific article published on December 6, 2012

A human embryonic stem cell line adapted for high throughput screening

scientific article published on 29 April 2013

A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression

scientific article

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice

scientific article published on 13 August 2007

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

scientific article

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway

scientific article published on November 2009

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

scientific article

Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway

scientific article published on July 2010

Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

scientific article published on 19 January 2017

Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice

scientific article

Cellular reprogramming of human amniotic fluid cells to express insulin

scientific article published on 19 June 2010

Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species

scientific article

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation

scientific article published on November 2009

Clinical application of glucagon-like Peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus

scientific article published on December 2013

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

scientific article

Closing in on Mass Production of Mature Human Beta Cells

scientific article published in June 2016

Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women

scientific article

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut.

scientific article published on 25 February 2010

Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

scientific article published on 30 October 2015

Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

scientific article published on 31 December 2016

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

scientific article

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance ⬇️

scientific article published on September 28, 2010

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation

scientific article published on 6 January 2017

Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1 ⬇️

scientific article published on 08 February 2011

Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice

scientific article

Engineering the gut for insulin replacement to treat diabetes

scientific article

Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently

scientific article published on 10 August 2004

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

scientific article published in November 2013

GIP or not GIP? That is the question

scientific article

Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents

scientific article

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

scientific article

Glucagon-like peptide-1: glucose homeostasis and beyond

scientific article

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

scientific article published on 22 September 2015

Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation.

scientific article published in February 2005

Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion

scientific article

Harnessing the gut to treat diabetes

scientific article

Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes

scientific article published on 7 October 2016

Hyperinsulinemia drives diet-induced obesity independently of brain insulin production

scientific article

Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling

scientific article published on 14 July 2010

Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice

scientific article published on 6 January 2016

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice

scientific article published on January 2014

Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination

scientific article

Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes

scientific article

Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice

scientific article published on 01 May 2012

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

scholarly article

In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and Motilin

scientific article published on 5 October 2017

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes ⬇️

scientific article published on September 14, 2010

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

scientific article

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells

scientific article

Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells

scientific article

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy

scientific article published on 22 December 2015

Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation

scientific article published on 27 September 2017

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes

Insulin-expressing engineered cell lines and primary cells: surrogate β cells from liver, gut, and other sources

scientific article published on February 2007

Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques ⬇️

scientific article published on January 18, 2013

K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease

scientific article published on January 1, 2010

Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis

scientific article published on 29 September 2010

Leptin administration enhances islet transplant performance in diabetic mice

scientific article published on 08 May 2013

Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

article

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis

scientific article published on 27 January 2014

Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats

scientific article published on 16 April 2008

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression

scientific article published on 19 February 2004

Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol

scientific article published on 26 February 2015

Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling.

scientific article published on 4 April 2011

Link between GIP and osteopontin in adipose tissue and insulin resistance

scientific article published on 24 January 2013

Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

scientific article published on 22 June 2017

Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling - two markers of addiction vulnerability

scientific article

Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology

scientific article

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

scientific article published on 16 June 2013

Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice

scientific article

Metabolic effects of chronic obestatin infusion in rats

scientific article published on 16 April 2008

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues

article published in 2019

Mining incretin hormone pathways for novel therapies

scientific article published on August 2009

Ontogeny of Ghrelin, Obestatin, Preproghrelin, and Prohormone Convertases in Rat Pancreas and Stomach

scientific article published on 01 January 2009

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

scientific article

Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation

scientific article published on February 2011

Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

scientific article published on 22 December 2015

Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis

scientific article published on 28 January 2014

Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells

scientific article

Pleiotropic effects of GIP on islet function involve osteopontin

scientific article

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

scientific article

Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells

scientific article published on 6 October 2015

Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells ⬇️

scientific article published on October 22, 2010

Profiling of circulating microRNAs in children with recent onset of type 1 diabetes

scientific article published on 23 February 2017

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

scientific article

Regenerative medicine and cell-based approaches to restore pancreatic function

scientific article published on 16 August 2017

Regulation of somatostatin release by adenosine in the mouse stomach

scientific article published on 10 February 2009

Replacing and safeguarding pancreatic β cells for diabetes

scientific article published in December 2015

Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia

scientific article

Restoring insulin production for type 1 diabetes.

scientific article published on December 2012

Reversal of diabetes by βTC3 cells encapsulated in alginate beads generated by emulsion and internal gelation

scientific article published on 10 February 2012

Sex differences in maturation of human embryonic stem cell-derived beta cells in mice

scientific article published on 5 February 2018

Statistical approaches and software for clustering islet cell functional heterogeneity

scientific article

Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep(ob/ob) mice

scientific article published on 21 September 2016

Targeting the glucagon receptor family for diabetes and obesity therapy ⬇️

scientific article published on June 1, 2012

The Role of ARX in Human Pancreatic Endocrine Specification

scientific article published on 3 December 2015

The glucoregulatory actions of leptin

scientific article published on 4 May 2017

The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis

scientific article published in October 2006

The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

scientific article

The role of leptin in glucose homeostasis

scientific article

Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice

scientific article

Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs

scientific article

Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells.

scientific article published on 23 April 2009

Treatment of diabetes with glucagon-like peptide-1 gene therapy ⬇️

scientific article published on October 28, 2010

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin

scientific article

Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation

article

WITHDRAWN: Involvement of Adenosine Signaling in Controlling the Release of Ghrelin from the Mouse Stomach ⬇️

retracted scientific article published on 21 January 2011

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