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List of works by Judy L. Bolton

6-Prenylnaringenin from Hops Disrupts ERα-mediated Downregulation of CYP1A1 to Facilitate Estrogen Detoxification

scientific article published on 28 September 2020

A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines

scientific article published on 01 May 2000

A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.

scientific article published on December 2002

A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus

scientific article published on 2 August 2017

Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells

scientific article

Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.

scientific article published in February 1998

Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin

scientific article

Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study

scientific article published on September 2005

Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. ⬇️

scientific article published on 23 September 2008

Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites

scientific article published in July 2003

Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity

scientific article published on 10 May 2007

Bioactivation of Selective Estrogen Receptor Modulators (SERMs)

scientific article published on September 2006

Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.

scientific article published on February 2005

Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

scientific article

Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement

scientific article

Biological characterization of non-steroidal progestins from botanicals used for women's health.

scientific article

Biological reactive intermediates (BRIs) formed from botanical dietary supplements ⬇️

scientific article published on October 21, 2010

Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.

scientific article published in May 1997

Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles

scientific article published in November 2002

Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.

scientific article

Botanical Integrity: Part 2: Traditional and Modern Analytical Approaches

scientific article published on 01 January 2016

Botanical Integrity: The Importance of the Integration of Chemical, Biological, and Botanical Analyses, and the Role of DNA Barcoding

scientific article published on 01 January 2015

Botanical modulation of menopausal symptoms: mechanisms of action?

scientific article

Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.

scientific article

Characterization of two new variants of human catechol O-methyltransferase in vitro.

scientific article

Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.

scientific article published on June 2004

Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator

scientific article published on June 2006

Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics

scientific article

Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides.

scientific article

Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense) ⬇️

scientific article

Correction to The Multiple Biological Targets of Hops and Bioactive Compounds

scientific article published on 08 August 2019

DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.

scientific article published on 16 August 2017

Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.

scientific article published on 05 August 2008

Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells

scientific article published on June 2009

Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

scientific article

Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo

scientific article published on 20 March 2013

Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay

scientific article

Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.

scientific article

Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase

scientific article published in April 2004

Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases

scientific article published in December 2001

Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression

scientific article published on June 2004

Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.

scientific article

Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus

scientific article published on 21 January 2009

Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin.

scientific article published in January 2008

Estrogens and congeners from spent hops (Humulus lupulus).

scientific article

Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms

scientific article published on 12 July 2013

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms

scientific article published in May 2001

Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.

scientific article

Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats

scientific article published on 04 October 2018

Formation and biological targets of botanical o-quinones

scientific article published on 29 July 2018

Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.

scientific article

High-content screening and mechanism-based evaluation of estrogenic botanical extracts

scientific article published on May 2008

Hop (Humulus lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation

scientific article

Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).

scientific article published on 13 October 2011

Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).

scientific article

In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent ⬇️

scientific article

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

scientific article

Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A

scientific article

Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.

scientific article

Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens

scientific article published on 01 July 1998

Integrated standardization concept for Angelica botanicals using quantitative NMR

scientific article

Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).

scientific article published on January 2004

Metabolic screening using on-line ultrafiltration mass spectrometry

scientific article published on 01 February 1998

Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.

scientific article published in October 2003

No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women

scientific article published on 16 November 2020

Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones

scientific article published on July 2004

Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.

scientific article

Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.

scientific article published on 23 December 2009

Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.

scientific article

Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts

scientific article published on March 2009

Potential mechanisms of estrogen quinone carcinogenesis

scientific article

Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase

scientific article published on 28 June 2008

Quinoids formed from estrogens and antiestrogens

scientific article published on January 2004

Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells

scientific article

Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.

scientific article published on 6 October 2017

Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens

scientific article

SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents

scientific article published on 18 September 2020

SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites

scientific article

Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial

scientific article

Screening botanical extracts for quinoid metabolites.

scientific article published in November 2001

Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry

scientific article

Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry

scientific article published on 01 June 1999

Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.

scientific article

Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity.

scientific article published in February 2006

Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity

scientific article published on 01 October 2000

Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol

scientific article

Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells

scientific article

Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis ⬇️

scientific article published on April 2006

Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.

scientific article published in April 2001

Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators

scientific article published on 20 October 2008

Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.

scientific article published in September 2007

Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.

scientific article

Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone

scientific article

Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones

scientific article published in December 2001

Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone.

scientific article published in June 2001

The Multiple Biological Targets of Hops and Bioactive Compounds

scientific article published on 22 January 2019

The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.

scientific article published on February 2008

The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.

scientific article published on March 2006

The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.

scientific article published in September 1998

The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone

scientific article published on February 1999

The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin

scientific article published on 28 January 2012

The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells

scientific article published on 01 September 1997

Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats

scientific article published on 01 January 2002

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

scientific article published on February 2005

Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation

scientific article

Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene

scientific article published on 13 July 2007

Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

scientific article

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