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List of works by Mary J LaDu

A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease

scientific article published on 29 April 2016

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model

scientific article published in Scientific Reports

APOE genotype alters glial activation and loss of synaptic markers in mice

scientific article published on 6 January 2012

APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice

scientific article published on 21 May 2019

APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice

scientific article published on 22 December 2013

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease.

scientific article

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

scientific article

APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice.

scientific article published on 15 April 2016

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.

scientific article

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

scientific article

Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

scientific article

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

scientific article

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro

scientific article

Apolipoprotein E Attenuates β‐Amyloid‐Induced Astrocyte Activation ⬇️

scientific article published on October 1, 1998

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.

scientific article published on 03 September 2013

Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain

scientific article published on 8 June 2016

Association of human, rat, and rabbit apolipoprotein E with ?-amyloid ⬇️

scientific article published on July 1, 1997

Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein

scientific article published in November 2002

Cytosolic Phospholipase A2 Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity

scientific article published on 15 August 2018

Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

scientific article

EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease.

scientific article published on 07 April 2017

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

scientific article

Expression of lipoprotein lipase during differentiation of cultured L6 muscle cells ⬇️

scientific article published on 01 March 1994

Genetics ignite focus on microglial inflammation in Alzheimer's disease

scientific article

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

scientific article published in May 1998

Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model

scientific article

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

scientific article

Introducing Human APOE into Aβ Transgenic Mouse Models ⬇️

scientific article published on October 19, 2011

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures ⬇️

scientific article published on January 1, 1998

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

scientific article

Nascent Astrocyte Particles Differ from Lipoproteins in CSF ⬇️

scientific article published on May 1, 1998

Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease.

scientific article published on 6 March 2018

Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease.

scientific article

Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift ⬇️

scientific article published on November 23, 2011

Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.

scientific article published on 20 December 2017

Proposed mechanism for lipoprotein remodelling in the brain.

scientific article published on 12 May 2010

Regulation of lipoprotein lipase in muscle and adipose tissue during exercise ⬇️

scientific article published on 01 August 1991

Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE.

scientific article published on 16 June 2016

Simultaneous analysis of dendritic spine density, morphology and excitatory glutamate receptors during neuron maturation in vitro by quantitative immunocytochemistry ⬇️

scientific article published on April 10, 2012

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

scientific article published on 04 January 2014

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice

scientific article published on 20 December 2019

The role of APOE in transgenic mouse models of AD

scientific article published on 28 May 2019

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

scientific article

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