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List of works by Ian R Wheeldon

A Strong Hybrid Fatty Acid Inducible Transcriptional Sensor Built From Yarrowia lipolytica Upstream Activating and Regulatory Sequences

scientific article

A chimeric fusion protein engineered with disparate functionalities-enzymatic activity and self-assembly.

scientific article

Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation.

scientific article published on 20 December 2017

Broadening the cofactor specificity of a thermostable alcohol dehydrogenase using rational protein design introduces novel kinetic transient behavior.

scientific article published on December 2010

CRISPR-Cas9-Mediated Genome Editing and Transcriptional Control in Yarrowia lipolytica

scientific article published on 01 January 2018

CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus

scientific article published on 24 June 2017

CRISPRi repression of nonhomologous end-joining for enhanced genome engineering via homologous recombination in Yarrowia lipolytica.

scientific article published on 19 August 2017

Catalysis of Thermostable Alcohol Dehydrogenase Improved by Engineering the Microenvironment through Fusion with Supercharged Proteins

scientific article published on 05 June 2019

Catalytic biomaterials: engineering organophosphate hydrolase to form self-assembling enzymatic hydrogels.

scientific article published on 10 May 2010

Controlled intracellular trafficking alleviates an expression bottleneck in ester biosynthesis

scientific article published on 26 December 2018

DNA Nanostructure Sequence-Dependent Binding of Organophosphates.

scientific article published on 6 February 2017

Dual N- and C-terminal helices are required for endoplasmic reticulum and lipid droplet association of alcohol acetyltransferases in Saccharomyces cerevisiae

scientific article

Engineering enzyme microenvironments for enhanced biocatalysis

scientific article published on 01 July 2018

Enhancing Enzyme Activity and Immobilization in Nanostructured Inorganic-Enzyme Complexes

scientific article published on 16 August 2017

Enzyme colocalization in protein-based hydrogels

scientific article published on 08 February 2019

Genome and metabolic engineering in non-conventional yeasts: Current advances and applications.

scientific article published on 31 August 2017

Guide RNA Engineering Enables Dual Purpose CRISPR-Cpf1 for Simultaneous Gene Editing and Gene Regulation in Yarrowia lipolytica

scientific article published on 02 April 2020

High throughput, colorimetric screening of microbial ester biosynthesis reveals high ethyl acetate production from Kluyveromyces marxianus on C5, C6, and C12 carbon sources.

scientific article

Highly multiplexed CRISPRi repression of respiratory functions enhances mitochondrial localized ethyl acetate biosynthesis in Kluyveromyces marxianus

scientific article published on 05 November 2018

Host and Pathway Engineering for Enhanced Lycopene Biosynthesis in Yarrowia lipolytica.

scientific article published on 20 November 2017

Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass

scientific article published on 30 March 2017

Mechanisms of Enhanced Catalysis in Enzyme-DNA Nanostructures Revealed through Molecular Simulations and Experimental Analysis.

scientific article

Microbial Attachment Inhibition through Low-Voltage Electrochemical Reactions on Electrically Conducting Membranes

scientific article published on 17 September 2015

Molecular Binding Scaffolds Increase Local Substrate Concentration Enhancing the Enzymatic Hydrolysis of VX Nerve Agent

scientific article published on 01 April 2020

Multiplexed CRISPR Activation of Cryptic Sugar Metabolism Enables Yarrowia Lipolytica Growth on Cellobiose

scientific article published on 18 May 2018

Quantifying Small Molecule Binding Interactions with DNA Nanostructures

scientific article published on 01 January 2018

Rapid ester biosynthesis screening reveals a high activity alcohol-O-acyltransferase (AATase) from tomato fruit.

scientific article published on 27 January 2016

Spot identification and quality control in cell-based microarrays.

scientific article published on August 2012

Standardized Markerless Gene Integration for Pathway Engineering in Yarrowia lipolytica.

scientific article published on 19 December 2016

Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis

scientific article published on 23 January 2020

Substrate channelling as an approach to cascade reactions.

scientific article published on March 2016

Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes.

scientific article

Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR-Cas9-Mediated Genome Editing in Yarrowia lipolytica.

scientific article

The Importance and Future of Biochemical Engineering

scientific article published on 28 April 2020

Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica

scientific article published on 16 June 2019

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