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List of works by Christopher A Ross

"Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness

scientific article

A Drosophila model for LRRK2-linked parkinsonism

scholarly article

A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation

scientific article published on 27 July 2016

A compact beta model of huntingtin toxicity

scientific article

A comparison of huntington disease and huntington disease-like 2 neuropathology

scientific article published in April 2008

A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.

scientific article

A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.

scientific article

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice

scientific article

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

scientific article

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease

scientific article published on 02 December 2016

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

scientific journal article

A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.

scientific article published on 2 February 2005

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line

scientific article

ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis.

scientific article published on 17 August 2016

Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T.

scientific article published on 18 August 2016

Acute kidney injury leads to inflammation and functional changes in the brain

scientific article published on 2 April 2008

Age, CAG repeat length, and clinical progression in Huntington's disease ⬇️

scientific article published on December 15, 2011

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla

scientific article published on 26 February 2016

Analysis of differential gene expression mediated by clozapine in human postmortem brains

scientific article

Animal models of gene-environment interactions in schizophrenia

scientific article

Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease

scientific article

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells

scientific article

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts

scientific article published on June 2004

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

scientific article

Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease

scientific article

Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity

scientific article published on 19 October 2007

Brain metabolite alterations and cognitive dysfunction in early Huntington's disease

scientific article

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

scholarly article

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset

scientific article

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

scientific article published on January 2003

Cerebral cortex structure in prodromal Huntington disease ⬇️

scientific article published on August 2, 2010

Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models.

scientific article published on April 2007

Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study

scientific article

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

scientific article

Cognitive impairment and psychiatric symptoms in 133 patients with diseases associated with cerebellar degeneration

scientific article published on January 2004

Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region

scientific article

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

scientific article published in November 2005

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism ⬇️

scientific article published on January 12, 2011

Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin ⬇️

scientific article published on February 10, 2011

DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders

scientific article published on 17 May 2016

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

scientific article published on September 2006

Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex

scientific article

Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction

scientific article

Diagnosis of Huntington Disease ⬇️

scientific article published on October 1, 2003

Diagnostic criteria for Huntington's disease based on natural history

scientific article published on 27 August 2014

Diffuse Abnormality of Low to Moderately Organized White Matter in Schizophrenia ⬇️

scientific article published on January 1, 2011

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

scientific article

Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain

scientific article published on 7 November 2008

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

scientific article

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

scientific article

Elevated arteriolar cerebral blood volume in prodromal Huntington's disease

scientific article published on 11 July 2013

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

scientific article published on 20 October 2005

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

scientific article published in May 2004

Evaluating cognition in individuals with Huntington disease: Neuro-QoL cognitive functioning measures

scientific article

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.

scientific article

Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes ⬇️

scientific article published on May 24, 2011

F177. THALAMIC SUBREGION RESTING STATE CONNECTIVITY IN SCHIZOPHRENIA MEASURED AT 7T.

scientific article published in April 2018

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

scientific article

FXTAS, SCA10, and SCA17 in American patients with movement disorders.

scientific article published in July 2005

Factors contributing to institutionalization in patients with Huntington's disease ⬇️

scientific article published on April 29, 2011

Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia ⬇️

scientific article published on March 6, 2013

Functional MRI study of a serial reaction time task in Huntington's disease

scientific article published in May 2004

Functional brain changes in presymptomatic Huntington's disease

scientific article published in June 2004

G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans

scientific article published on 07 November 2018

Gabriele Schilling (September 5, 1968-July 4, 2014).

scientific article published in January 2014

Gene-environment interactions in Parkinson's disease

scientific article published on January 2007

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study

scientific article

Gross feature recognition of Anatomical Images based on Atlas grid (GAIA): Incorporating the local discrepancy between an atlas and a target image to capture the features of anatomic brain MRI.

scientific article published on 14 August 2013

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

scientific article published on 3 March 2015

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

scientific article published in November 2005

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

scientific article published on 16 June 2006

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

scientific article

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

scientific article published on 8 August 2002

Huntington disease

Huntington disease: natural history, biomarkers and prospects for therapeutics

scientific article

Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics

scientific article published in December 2009

Huntington's Disease-like 2 (HDL2) in North America and Japan

scientific article published in November 2004

Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci

scientific article published in March 2007

Huntington's disease: a field on the move. Introduction

scientific article published on 27 August 2014

Huntington's disease: from molecular pathogenesis to clinical treatment

scientific article

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

scientific article (publication date: June 2003)

Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein ⬇️

scientific article published on March 20, 2012

Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders

scientific article published on 16 October 2001

Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease ⬇️

scientific article published on March 7, 2012

Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation

scientific article published in March 2003

Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype

scientific article

Kinase activity of mutant LRRK2 mediates neuronal toxicity

scientific article

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin ⬇️

scientific article published on June 2, 2012

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

scientific article

Linking white matter and deep gray matter alterations in premanifest Huntington disease

scientific article published on 26 February 2016

Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations

scientific article published on April 2009

Longitudinal change in regional brain volumes in prodromal Huntington disease

scientific article

Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images

scientific article

Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis.

scientific article

Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease

scientific article

Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies

scientific article

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease

scientific article published on 16 March 2016

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients

scientific article

Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study

scientific article

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

scientific article

Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3.

scientific article published on January 2005

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH

scholarly article

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease

scientific article

Neurobiology of schizophrenia

scientific article published on 01 October 2006

Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12

scientific article published on 04 September 2015

Neuroprotective effects of PPAR‐γ agonist rosiglitazone in N171‐82Q mouse model of Huntington's disease ⬇️

scientific article published on March 5, 2013

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

scientific article published on 18 December 2011

Neuropsychological deficits in Huntington's disease gene carriers and correlates of early "conversion".

scientific article

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

scientific journal article

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

scientific article

PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation

scientific journal article

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

scientific article published on 7 December 2015

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).

scientific article published in January 2015

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

scientific article

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death

scientific article

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

scientific article

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity

scientific article

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

scientific article

Polyglutamine expansion of huntingtin impairs its nuclear export

scientific article

Polyglutamine fibrillogenesis: the pathway unfolds

scholarly article

Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset

scientific article

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

scientific article

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

scientific article

Potential Therapeutic Targets for Neurodegenerative Diseases: Lessons Learned from Calorie Restriction ⬇️

scientific article published on October 1, 2010

Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study

scientific article

Predictors of neuropathological severity in 100 patients with Huntington's disease

scientific article published in October 2003

Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction

scientific article published on 18 June 2013

Prefrontal executive function associated coupling relates to Huntington's disease stage

scientific article published on 26 June 2013

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology

scientific article

Preparing for preventive clinical trials: the Predict-HD study

scientific article published in June 2006

Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history.

scientific article published on 11 September 2006

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

scientific article

Protein aggregation and neurodegenerative disease

scientific article

Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's disease.

scientific article

Quantitative Proteomic Analysis Reveals Similarities between Huntington's Disease (HD) and Huntington's Disease-Like 2 (HDL2) Human Brains

scientific article published on 3 August 2016

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease.

scientific article published on 17 December 2015

RAN Translation in Huntington Disease

scientific article

Regional atrophy associated with cognitive and motor function in prodromal Huntington disease

scientific article

Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study

scientific article published on 30 September 2005

Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

scientific article

Resting-state functional MRI reveals altered brain connectivity and its correlation with motor dysfunction in a mouse model of Huntington's disease

scientific article published in December 2017

Schizophrenia: A point of disruption

scientific article published in April 2009

Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort

scientific article

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

scientific article published on 10 March 2008

Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice.

scientific article

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

scientific article published on 7 February 2008

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

scientific article

Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment

scientific article

Sox11 Reduces Caspase-6 Cleavage and Activity

scientific article published on 27 October 2015

Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging

scientific article published on 9 February 2012

Striatal and white matter predictors of estimated diagnosis for Huntington disease

scientific article

Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease

scientific article

Striatal volume contributes to the prediction of onset of Huntington disease in incident cases

scientific article published on 9 September 2011

Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model

scientific article

Synaptic dysregulation in a human iPS cell model of mental disorders

scientific article published on 17 August 2014

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models

scientific article

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

scientific article

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

scientific article

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease

scientific article

Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior

scientific article published in April 2002

Targeting H3K4 trimethylation in Huntington disease

scientific article published on 19 July 2013

The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model

scientific article published on 9 November 2007

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

scientific article

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

scientific article

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease

scientific article published on 4 July 2016

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

scientific article published in January 2012

Transglutaminase cross-links in intranuclear inclusions in Huntington disease

scientific article published on January 2003

Trinucleotide repeat expansions in the junctophilin-3 gene are not found in Caucasian patients with a Huntington's disease-like phenotype.

scientific article

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

scholarly article

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

scientific article published on 07 June 2016

Verbal episodic memory declines prior to diagnosis in Huntington's disease

scientific article published on 09 January 2007

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

scientific article published in July 2005

trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease

scientific article

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