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List of works by Blair R Leavitt

8OHdG as a marker for Huntington disease progression ⬇️

scientific article published on 05 March 2012

8OHdG is not a biomarker for Huntington disease state or progression

scientific article published on 24 April 2013

A Computational Cognitive Biomarker for Early-Stage Huntington's Disease

scientific article published on 12 February 2016

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

scientific article

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers

scientific article published on 18 February 2015

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

scientific article

A systematic review and meta-analysis of clinical variables used in Huntington disease research

scientific article published on 18 October 2013

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

scientific article

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease

scientific article

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease

scientific article published on 15 July 2013

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

scientific article

Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease

Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study

article published in 2018

Aquatherapy for neurodegenerative disorders

scientific article

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

scientific article

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

scientific article

Body weight is modulated by levels of full-length huntingtin

scientific article published on 28 March 2006

Brain Regions Showing White Matter Loss in Huntington's Disease Are Enriched for Synaptic and Metabolic Genes

scientific article

Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease

scientific article

CAG-encoded polyglutamine length polymorphism in the human genome

scientific article

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

scientific article published on September 2002

Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease

scientific article published on 25 June 2016

Chapter 15 Juvenile amyotrophic lateral sclerosis

scientific article published in January 2007

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

scientific article published in June 2006

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy

scientific article published on 18 November 2011

Clinical utility gene card for: Huntington's disease

scientific article published on 9 October 2013

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

scientific article

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

scientific article

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study

scientific article

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice

scientific article published on 21 June 2017

Corpus callosal atrophy in premanifest and early Huntington's disease

scientific article published on January 2013

Correction of inter-scanner and within-subject variance in structural MRI based automated diagnosing

scientific article published on 29 April 2014

Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease

scientific article published on 25 October 2017

Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

scientific article published in March 2005

Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice

scientific article

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

scientific article published in October 2005

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons

scientific article published on January 2012

Depletion of wild-type huntingtin in mouse models of neurologic diseases

scientific article published in October 2003

Design optimization for clinical trials in early-stage manifest Huntington's disease

scientific article

Detection of Motor Changes in Huntington's Disease Using Dynamic Causal Modeling

scientific article

Development of biomarkers for Huntington's disease

scientific article

Diagnostic criteria for Huntington's disease based on natural history

scientific article published on 27 August 2014

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

scientific article published on February 2009

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

scientific article published on 06 May 2015

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

scientific article published on August 2002

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial

scientific article published on July 2016

Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease

scientific article

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

scientific journal article

Epidemiology of Huntington disease

scientific article

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

scientific article

Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease.

scientific article

Expression analysis of novel striatal-enriched genes in Huntington disease

scientific article

Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease

scientific article published on 31 August 2006

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease

scientific article published on 6 April 2012

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development

scientific article published on 05 October 2012

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

scientific article

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

scientific article

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

scientific article (publication date: November 2002)

Huntingtin inhibits caspase-3 activation

scientific journal article

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

scientific article (publication date: September 2003)

Huntingtin proteolysis in Huntington disease

Huntington disease

Huntington disease: natural history, biomarkers and prospects for therapeutics

scientific article

Huntington's disease: a field on the move. Introduction

scientific article published on 27 August 2014

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

scientific article published on 19 June 2017

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

scientific article

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

scientific article published in March 2002

Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease

scientific article

Introducing the "Clinical Trials Corner".

scientific article

Iron dysregulation in Huntington's disease

scientific article

Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?

scientific article published on 01 October 2006

Journal of Huntington's Disease

scientific article published in January 2012

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance

scientific article

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

scientific article published on 17 October 2005

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

scientific article published in January 2004

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

scientific article published on 13 April 2005

Medication Use in Early-HD Participants in Track-HD: an Investigation of its Effects on Clinical Performance

scientific article published on 11 January 2016

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

scientific article

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

scientific article

Natural biological variation of white matter microstructure is accentuated in Huntington's disease

scientific article published on 22 April 2018

Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease

scientific article published in August 2016

Neurobiology of Huntington's Disease

scientific article published on January 2015

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

scientific article

Neurofilament light protein in blood predicts regional atrophy in Huntington disease

scientific article

Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment

scientific article

Operationalizing compensation over time in neurodegenerative disease

scientific article published on 23 February 2017

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

scientific article

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

scientific article published on October 2010

Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model

scientific article

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

scientific article

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

scientific article published in March 2004

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

scientific article

Progranulin in neurodegenerative disease

scientific article published on 04 May 2014

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus

scientific article

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery

scientific article published on 7 October 2015

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

scientific article

Quality of life in Huntington's disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners

scientific article

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

scientific article

Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats

scientific article published on 01 September 2008

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease

scientific article

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

scientific article

Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies

scientific article

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

scientific article published on December 2003

Satellog: a database for the identification and prioritization of satellite repeats in disease association studies.

scientific article

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

scientific article published on 8 November 2005

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

scientific article published on 17 November 2017

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

scientific article published in July 2003

Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice

scientific article published on 21 May 2013

Striatal neurochemical changes in transgenic models of Huntington's disease

scientific article

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

scientific article published on 13 September 2005

Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease

scientific article

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis

scientific article

Synaptic dysfunction in progranulin-deficient mice

scientific article published on 25 October 2011

Testicular degeneration in Huntington disease.

scientific article

Testing a longitudinal compensation model in premanifest Huntington's disease

Tetrabenazine

scientific article published in January 2009

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)

scientific article

The clinical and genetic features of Huntington disease

scientific article published on 05 October 2010

The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease

scientific article published on 28 October 2015

The potential of composite cognitive scores for tracking progression in Huntington's disease

scientific article published on January 2014

The structural involvement of the cingulate cortex in premanifest and early Huntington's disease

scientific article

Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington's disease

scientific article

Transcriptional Regulation of the Huntingtin Gene

article

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

scientific article

Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole

scientific article published in January 2015

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease

scientific article published on 30 June 2005

Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay

scientific article published on 9 November 2017

Visual Working Memory Impairment in Premanifest Gene-Carriers and Early Huntington's Disease

scientific article

Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease

scientific article published on 23 May 2016

We are pleased to introduce this next volume of the Journal of Huntington's Disease. Introduction

scientific article published in January 2013

White matter predicts functional connectivity in premanifest Huntington's disease

scientific article published on 16 January 2017

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

scientific article published on 5 December 2006

Wild-type huntingtin protects neurons from excitotoxicity

scientific article published on 17 January 2006

YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth

scientific article published on 5 July 2011

p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease

scientific article published on 5 April 2017

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