List of works - Jakub Jończyk

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease

scientific article published on 26 November 2019

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

scientific article published on 24 March 2014

Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities

scientific article published on 04 December 2018

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

scientific article published on 20 April 2016

Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies

scientific article published on 03 June 2015

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

scientific article published on 18 January 2018

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.

scientific article published on 7 February 2018

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

scientific article published on 26 September 2016

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease

scientific article published on 24 January 2019

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines.

scientific article

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity

scientific article published on 03 June 2020

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity

scientific article published on 02 May 2012

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

scientific article published on 5 October 2017

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

scientific article published on 27 January 2021

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease

scientific article published on 01 December 2020

New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer's Disease

scientific article published on 26 May 2020

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease

scientific article published in December 2017

New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors

scientific article published on 29 July 2020

New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis.

scientific article published on 4 March 2013

Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies

scientific article published on 10 November 2015

Novel carbamate derivatives as selective butyrylcholinesterase inhibitors.

scientific article published on 3 March 2018

Pathological Subtrochanteric Femoral Fracture Due to Extensive Arterio-venous Malformation. A Case Study

scientific article published on 01 May 2015

Risk assessment of accidental exposure of surgeons to blood during orthopedic surgery. Are we safe in surgical gloves?

scientific article published on January 2014

Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives

scientific article published on 26 June 2019

Structure modeling of γ-aminobutyric acid transporters - Molecular basics of ligand selectivity

scientific article published on 03 May 2020

Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.