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List of works by Melanie Brinkmann

A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity.

scientific article published on 22 March 2017

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling

scientific article published on 12 April 2013

Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein

scientific article

Age-dependent enterocyte invasion and microcolony formation by Salmonella

scientific article (publication date: September 2014)

An action plan for pan-European defence against new SARS-CoV-2 variants

Calling for pan-European commitment for rapid and sustained reduction in SARS-CoV-2 infections

scientific article published on 18 December 2020

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice

scientific article published on 12 December 2012

Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

scientific article published on 25 February 2019

Cytomegalovirus immune evasion of myeloid lineage cells

scientific article published on 17 March 2015

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

scientific article published on 25 January 2016

Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus

scientific article

Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition.

scientific article published on 26 July 2018

German translation, cross-cultural adaptation and validation of the Musculoskeletal Health Questionnaire: cohort study

scientific article published on 25 September 2020

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling ⬇️

scientific article published on April 14, 2011

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

scientific article published on 26 April 2016

IRAP+ endosomes restrict TLR9 activation and signaling

scientific article

Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus

scientific article

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.

scientific article

Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest

scientific article

Large-scale purification, dissociation and functional reassembly of the maltose ATP-binding cassette transporter (MalFGK(2)) of Salmonella typhimurium

scientific article

Measurement of mouse cytomegalovirus-induced interferon-β with immortalized luciferase reporter cells

scientific article published on January 2013

Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus

scientific article published on 18 October 2006

Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop

scientific article

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication

scientific article published on 08 October 2020

Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes

scientific article published on 06 December 2012

Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression

scientific article published on 07 July 2020

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs)

scientific article published on 07 February 2020

Protein tyrosine phosphatase 1B (PTP1B) is involved in efficient type I interferon secretion upon viral infection

scientific article published on 07 April 2020

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

scientific article

Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae

scientific article

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation

scientific article

SARS-CoV-2 outbreak investigation in a German meat processing plant

scientific article published on 04 October 2020

Strategies for immune evasion by human tumor viruses

scientific article published on 18 September 2018

Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.

scientific article published on 19 September 2013

TLRs bent into shape

scientific article published on 01 July 2007

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

scientific article

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

scientific article published on 26 May 2020

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages

scientific article

The endosomal Toll-like receptors 7 and 9 cooperate in detection of MHV68 infection

scientific article published on 17 January 2019

The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response

scientific article

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection

scientific article published on 29 January 2019

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

scientific journal article

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. ⬇️

scientific article published on 2 March 2018

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription

scientific article (publication date: May 2017)

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

scientific article

Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade

scientific article published on 2 February 2012

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