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List of works by Matthias Staufenbiel

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

scientific article

A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.

scientific article published in January 2004

APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques

scientific article published in January 2002

APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder

scientific article

APP23 mice display working memory impairment in the plus-shaped water maze

scientific article published on 7 September 2006

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

scientific article

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

scientific article

Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.

scientific article

Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice.

scientific article published on 23 July 2009

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

scientific article published in January 2003

Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.

scientific article published in September 2003

Aggressive male APP23 mice modeling behavioral alterations in dementia

scientific article published on 01 December 2006

Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances

scientific article published on 01 November 2004

Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model

scientific article published in June 2008

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease

scholarly article

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification ⬇️

scientific article published on July 14, 2009

Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons

scientific article published on 16 August 2003

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

scientific article published on 20 November 2017

Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease

scientific article published on 14 July 2013

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

scientific article published in January 2002

Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties

scientific article

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

scientific article published in June 2013

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

scientific article

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models

scientific article published on 17 January 2005

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

scientific journal article

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis

scientific article published on 12 July 2017

BACE inhibition-dependent repair of Alzheimer's pathophysiology

scientific article

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice

scientific article published in January 2007

Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid

scientific article

Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice

scientific article published on 20 November 2012

Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model

scholarly article

Brain homogenates from human tauopathies induce tau inclusions in mouse brain ⬇️

scientific article published on May 20, 2013

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

scientific article

Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances

scientific article published on 21 March 2008

Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein ⬇️

scientific article published on July 17, 2013

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

scientific article

Chronic Administration of Anti-Stroke Herbal Medicine TongLuoJiuNao Reduces Amyloidogenic Processing of Amyloid Precursor Protein in a Mouse Model of Alzheimer’s Disease ⬇️

scientific article published on March 5, 2013

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

scientific article published in September 2008

Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease

scientific article published on 27 June 2006

Compromised hemodynamic response in amyloid precursor protein transgenic mice.

scientific article published in August 2002

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

scientific article

Cystatin C modulates cerebral beta-amyloidosis

scientific article

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

scientific article

Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice

scientific article

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

scientific article

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

scientific article

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides

scientific article

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides

scientific article

Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.

scientific article published on 2 February 2012

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

scientific article

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition

scientific article published on 7 August 2008

E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition

scientific article published on 13 February 2009

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

scientific article

Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory

scientific article published on 16 February 2008

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

scientific article published on 20 February 2008

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

scientific article

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

scientific article

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

scientific article

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment

scientific article

Extracellular amyloid formation and associated pathology in neural grafts

scientific article published in April 2003

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

scientific article

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.

scientific article

Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment

scientific article

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

scientific article published on January 2013

Highly potent intracellular membrane-associated Aβ seeds

scientific article published on 17 June 2016

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

scientific article

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

scholarly article

Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies

scientific article

Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype

scientific article

Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia

scientific article published on 28 January 2016

In VivoPositron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders ⬇️

scientific article published on March 23, 2011

In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe

scientific article published on 17 April 2005

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models

scientific article published on 15 May 2015

Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.

scientific article

Independent effects of intra- and extracellular Abeta on learning-related gene expression

scientific article published on July 2009

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.

scientific article published in March 2004

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

scientific article

Innate immune memory in the brain shapes neurological disease hallmarks

scientific article published in Nature

Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.

scientific article published in November 2005

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

scientific article

Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition

scientific article

Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.

scientific article

Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease

scientific article

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

scientific article published on 17 May 2016

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

scientific article published in October 2007

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application

scientific article

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo

scientific article

Magnetic resonance angiography and vascular corrosion casting as tools in biomedical research: application to transgenic mice modeling Alzheimer's disease

scientific article published in July 2004

Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology ⬇️

scientific article published on December 15, 2011

Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.

scientific article published in December 2013

Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers

scientific article published on 30 April 2009

Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry

scientific article published in December 2002

Mood and male sexual behaviour in the APP23 model of Alzheimer's disease

scientific article published on 12 March 2007

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

scientific article published on July 2014

Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice

scientific article published in May 2005

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

scientific article published on 24 April 2006

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

scientific article published on 9 June 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

scientific article published on 20 July 2016

Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis

scientific article published on 8 May 2008

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta

scientific article

Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23).

scientific article published in December 2003

Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immuno

scientific article published on January 19, 2011

Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety

scholarly article

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

scientific article

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice

scientific article

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

scientific article published on 21 October 2010

Persistence of Aβ seeds in APP null mouse brain

scientific article published on 9 September 2015

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

scientific article published in June 2006

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

scientific article published on 14 October 2016

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

scientific article published in July 2002

Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.

scientific article published in February 2008

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice

scientific article published on 31 March 2010

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

scientific article published in April 2013

Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis

scientific article published on 01 August 2004

Role of hippocalcin in mediating Aβ toxicity

scientific article

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

scientific article

Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.

scientific article

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

scientific article published on October 2011

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease ⬇️

scientific article published on April 10, 2012

Statin Therapy and the Development of Cerebral Amyloid Angiopathy--A Rodent in Vivo Approach

scientific article published on 19 January 2016

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

scientific article published on 15 January 2005

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing ⬇️

scientific article published on September 1, 2011

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

scientific article

Thrombolysis in experimental cerebral amyloid angiopathy and the risk of secondary intracerebral hemorrhage

scientific article published on 8 July 2014

Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy

scientific article published in June 2002

Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

scientific article published on 17 July 2013

Transmission and spreading of tauopathy in transgenic mouse brain

scientific article

Vaccination with Abeta-displaying virus-like particles reduces soluble and insoluble cerebral Abeta and lowers plaque burden in APP transgenic mice

scientific article

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

scientific article published on 27 October 2008

Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage

scientific article published on 20 January 2006

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

scientific article

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