Search filters

List of works by Silke Nuber

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

scientific article published in February 2013

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

scientific article (publication date: 2010)

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease

scholarly article by Silke Nuber et al published 10 October 2018 in Neuron

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

scientific article published on 24 March 2014

Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

scientific article

Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein

scientific article published on 9 January 2013

Caspase-1 clipping causes complications for α-synuclein

scientific article published on 22 August 2016

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein

scientific article

Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein

scientific article published on 9 October 2015

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

scientific article

Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models.

scientific article

First appraisal of brain pathology owing to A30P mutant alpha-synuclein

scientific article published in May 2010

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

scientific article

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

scientific article published on 17 December 2014

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

scientific article

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

scientific article published on 24 November 2015

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

scientific article published on 27 December 2016

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

scientific article published in March 2008

Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages

scientific article

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

scientific article

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

scientific article

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

scientific article

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

scientific article

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice

scientific article published in February 2010

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

scientific article

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

scientific article