List of works - Yang-Chang Wu

16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis.

scientific article published on 19 April 2011

16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells ⬇️

scientific article published on September 29, 2011

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice

scientific article published on 14 September 2018

4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells

scientific article published on 4 August 2017

4β-Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells.

scientific article

6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice

scientific article published on 17 January 2017

Alkaloids from Pandanus amaryllifolius: Isolation and Their Plausible Biosynthetic Formation.

scientific article published on 13 October 2015

An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii.

scientific article published on 13 April 2013

Anti-Inflammatory Spirostanol and Furostanol Saponins from Solanum macaonense

scientific article

Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx

scientific article published on 22 October 2016

Anti-inflammatory triterpenoids from the stems of Microtropis fokienensis.

scientific article

Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum

scientific article published on 06 July 2013

Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis

scientific article published on 21 March 2016

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction.

scientific article

Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells

scientific article published on 27 March 2018

Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis.

scientific article

Automatic morphological subtyping reveals new roles of caspases in mitochondrial dynamics

scientific article

Bioactive Phenolic Components from the Twigs of Atalantia buxifolia

scientific article published on 05 July 2018

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus.

scientific article published on 12 July 2017

Bioactive constituents of Cirsium japonicum var. australe

scientific article

Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).

scientific article published on 10 December 2016

Briarane Diterpenoids Isolated from Octocorals between 2014 and 2016

scientific article

Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013

scientific article

Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae).

scientific article

Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum.

scientific article

Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis.

scientific article published on 17 June 2013

Characterization of Secondary Metabolites from Purple Ipomoea batatas Leaves and Their Effects on Glucose Uptake.

scientific article published on 8 June 2016

Chemical constituents and bioactivities of Clinacanthus nutans aerial parts.

scientific article published on 5 December 2014

Cladieunicellins M-Q, new eunicellins from Cladiella sp

scientific article

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.

scientific article

Copper-catalyzed oxidative coupling of formamides with salicylaldehydes: synthesis of carbamates in the presence of a sensitive aldehyde group.

scientific article

Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction

scientific article

Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

scientific article

Diterpenes from Grangea maderaspatana

scientific article published on 23 August 2016

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era.

scientific article

Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan.

scientific article

Efficient synthesis of boron-containing α-acyloxyamide analogs via microwave irradiation.

scientific article published on 8 August 2013

Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications

scientific article published on 04 September 2018

Fermented Citrus Lemon Reduces Liver Injury Induced by Carbon Tetrachloride in Rats.

scientific article

Fragilides K and L, New Briaranes from the Gorgonian Coral Junceella fragilis

scientific article published on 22 June 2018

Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens

scientific article published in Scientific Reports

Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties

scientific article published on 07 March 2019

Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis.

scientific article published on 26 April 2017

Inhibitory Effects of Purple Sweet Potato Leaf Extract on the Proliferation and Lipogenesis of the 3T3-L1 Preadipocytes

scientific article published on 24 July 2015

Iron-catalyzed oxidative direct α-C-H bond functionalization of cyclic ethers: selective C-O bond formation in the presence of a labile aldehyde group

scientific article published on 17 March 2014

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.

scientific article published on 14 June 2018

Isoprenoids from the Soft Coral Sarcophyton glaucum

scientific article

Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives.

scientific article published on 22 July 2015

Natural Product Chemistry of Gorgonian Corals of Genus ⁻Part III

scientific article published on 17 September 2018

Natural product chemistry of gorgonian corals of the family Plexauridae distributed in the Indo-Pacific Ocean

scientific article

New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae).

scientific article published on 9 January 2016

New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

scientific article

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.

scientific article published on 29 May 2015

New Anti-inflammatory Norcembranoids from the Soft Coral Sinularia numerosa.

scientific article

New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

scientific article published on 14 July 2015

New anti-inflammatory sterols from a gorgonian Pinnigorgia sp.

scientific article

Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells.

scientific article published on 25 December 2013

Norcantharidin induces apoptosis in human prostate cancer cells through both intrinsic and extrinsic pathways.

scientific article published on 29 April 2016

Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa.

scientific article

Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicillium antillanum.

scientific article published on 11 March 2017

Oxygenated ylangene-derived sesquiterpenoids from the soft coral Lemnalia philippinensis.

scientific article published on 30 September 2013

Pinnisterols A-C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

scientific article published on 7 January 2016

Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis.

scientific article

Pregnenolone derivatives as potential anticancer agents.

scientific article published on 22 September 2011

Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy.

scientific article published on 14 January 2016

Protoapigenone derivatives: albumin binding properties and effects on HepG2 cells.

scientific article published on 13 April 2013

Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.

scientific article published on 11 June 2015

Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration

scientific article published on 22 December 2015

Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies.

scientific article

Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies.

scientific article

Rumphellols A and B, new caryophyllene sesquiterpenoids from a Formosan gorgonian coral, Rumphella antipathies

scientific article

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K.

scientific article published on 15 May 2011

Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models

scientific article published on 22 February 2017

Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.

scientific article published on 26 February 2013

Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp.

scientific article

Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells.

scientific article published on 22 October 2015

Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

scientific article published on 09 November 2018

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina.

scientific article

Survival benefit of sphingosin-1-phosphate and receptors expressions in breast cancer patients

scientific article published on 20 June 2018

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters.

scientific article

Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors.

scientific article

TNF-alpha induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways.

scientific article published on August 2010

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities.

scientific article published on 20 May 2015

Terpenoids from Octocorals of the Genus Pachyclavularia.

scientific article

The Roles of 4β-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells

scientific article published on 24 April 2016

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.

scientific article published on 7 May 2015

The small molecule calactin induces DNA damage and apoptosis in human leukemia cells.

scientific article

The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling.

scientific article published on 18 October 2013

Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats

scientific article

List of works by Yang-Chang Wu

16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis.

16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells ⬇️

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice

4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells

4β-Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells.

6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice

Alkaloids from Pandanus amaryllifolius: Isolation and Their Plausible Biosynthetic Formation.

An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii.

Anti-Inflammatory Spirostanol and Furostanol Saponins from Solanum macaonense

Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx

Anti-inflammatory triterpenoids from the stems of Microtropis fokienensis.

Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum

Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction.

Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells

Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis.

Automatic morphological subtyping reveals new roles of caspases in mitochondrial dynamics

Bioactive Phenolic Components from the Twigs of Atalantia buxifolia

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus.

Bioactive constituents of Cirsium japonicum var. australe

Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).

Briarane Diterpenoids Isolated from Octocorals between 2014 and 2016

Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013

Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae).

Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum.

Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis.

Characterization of Secondary Metabolites from Purple Ipomoea batatas Leaves and Their Effects on Glucose Uptake.

Chemical constituents and bioactivities of Clinacanthus nutans aerial parts.

Cladieunicellins M-Q, new eunicellins from Cladiella sp

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core.

Copper-catalyzed oxidative coupling of formamides with salicylaldehydes: synthesis of carbamates in the presence of a sensitive aldehyde group.

Cracking the cytotoxicity code: apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction

Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

Diterpenes from Grangea maderaspatana

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era.

Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan.

Efficient synthesis of boron-containing α-acyloxyamide analogs via microwave irradiation.

Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications

Fermented Citrus Lemon Reduces Liver Injury Induced by Carbon Tetrachloride in Rats.

Fragilides K and L, New Briaranes from the Gorgonian Coral Junceella fragilis

Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties

Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis.

Inhibitory Effects of Purple Sweet Potato Leaf Extract on the Proliferation and Lipogenesis of the 3T3-L1 Preadipocytes

Iron-catalyzed oxidative direct α-C-H bond functionalization of cyclic ethers: selective C-O bond formation in the presence of a labile aldehyde group

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.

Isoprenoids from the Soft Coral Sarcophyton glaucum

Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives.

Natural Product Chemistry of Gorgonian Corals of Genus ⁻Part III

Natural product chemistry of gorgonian corals of the family Plexauridae distributed in the Indo-Pacific Ocean

New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae).

New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris.

New Anti-inflammatory Norcembranoids from the Soft Coral Sinularia numerosa.

New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

New anti-inflammatory sterols from a gorgonian Pinnigorgia sp.

Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells.

Norcantharidin induces apoptosis in human prostate cancer cells through both intrinsic and extrinsic pathways.

Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa.

Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicillium antillanum.

Oxygenated ylangene-derived sesquiterpenoids from the soft coral Lemnalia philippinensis.

Pinnisterols A-C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis.

Pregnenolone derivatives as potential anticancer agents.

Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy.

Protoapigenone derivatives: albumin binding properties and effects on HepG2 cells.

Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes.

Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration

Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies.

Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies.

Rumphellols A and B, new caryophyllene sesquiterpenoids from a Formosan gorgonian coral, Rumphella antipathies

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K.

Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models

Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.

Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp.

Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells.

Study of the anti-allergic and anti-inflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina.

Survival benefit of sphingosin-1-phosphate and receptors expressions in breast cancer patients