List of works - Vilím Šimánek

A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat.

scientific article

Analysis of anthocyanin pigments in Lonicera (Caerulea) extracts using chromatographic fractionation followed by microcolumn liquid chromatography-mass spectrometry

scientific article published on 2 June 2010

Antioxidant activity of extracts from the leaves of Smallanthus sonchifolius.

scientific article

Biomedical Papers: present state and our aspirations for the year 2010

scientific article published on 01 December 2009

Capillary zone electrophoretic studies of interactions of some quaternary isoquinoline alkaloids with DNA constituents and DNA.

scientific article published in May 2005

Carcinogenic potential of sanguinarine, a phytochemical used in 'therapeutic' black salve and mouthwash

scientific article published on 6 September 2017

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

scientific article published in February 2004

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. caffeic, chlorogenic and rosmarinic acids

scientific article

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin

scientific article

Constituents and antimicrobial properties of blue honeysuckle: a novel source for phenolic antioxidants

scientific article

Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes

scientific article published on 01 June 2007

Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.

scientific article published on 12 May 2006

DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique

scientific article published in August 2002

Determination of the glycaemic index of selected foods (white bread and cereal bars) in healthy persons.

scientific article published on July 2004

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

scientific article published in November 2002

Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.

scientific article

Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group

scientific article published in November 2003

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

scientific article

Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms.

scientific article published on 22 July 2009

Fluorescence of sanguinarine: spectral changes on interaction with amino acids

scientific article published on 3 August 2010

HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection

scientific article published on 21 August 2007

Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry.

scientific article published on 25 February 2010

Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin

scientific article

Interaction of sanguinarine and its dihydroderivative with the Na+/K+-ATPase. Complex view on the old problem

scientific article published on 10 April 2010

Liquid chromatographic/electrospray mass spectrometric determination (LC/ESI-MS) of chelerythrine and dihydrochelerythrine in near-critical CO(2) extracts from real and spiked plasma samples.

scientific article

Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study.

scientific article published in February 2010

Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment.

scientific article published in November 2007

Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.

scientific article

Macleya cordata and Prunella vulgaris in oral hygiene products - their efficacy in the control of gingivitis

scientific article published on 01 July 2004

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

scientific article published on July 2010

Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.

scientific article

Phytochemical and antimicrobial characterization of Macleaya cordata herb

scientific article

Plasma lipoproteins in transport of silibinin, an antioxidant flavonolignan from Silybum marianum.

scientific article published in May 2003

Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum

scientific article published in February 2003

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.

scientific article published in August 2005

Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.

scientific article published in January 2004

Silybin is metabolized by cytochrome P450 2C8 in vitro.

scientific article published in August 2007

The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms

scientific article

The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals?

scientific article

The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat

scientific article published on 01 June 2007

The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial.

scientific article published on September 2010

The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study

scientific article published on 15 April 2008

List of works by Vilím Šimánek

A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat.

Analysis of anthocyanin pigments in Lonicera (Caerulea) extracts using chromatographic fractionation followed by microcolumn liquid chromatography-mass spectrometry

Antioxidant activity of extracts from the leaves of Smallanthus sonchifolius.

Biomedical Papers: present state and our aspirations for the year 2010

Capillary zone electrophoretic studies of interactions of some quaternary isoquinoline alkaloids with DNA constituents and DNA.

Carcinogenic potential of sanguinarine, a phytochemical used in 'therapeutic' black salve and mouthwash

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part II. caffeic, chlorogenic and rosmarinic acids

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin

Constituents and antimicrobial properties of blue honeysuckle: a novel source for phenolic antioxidants

Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes

Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.

DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique

Determination of the glycaemic index of selected foods (white bread and cereal bars) in healthy persons.

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.

Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

Fluorescence of sanguinarine: fundamental characteristics and analysis of interconversion between various forms.

Fluorescence of sanguinarine: spectral changes on interaction with amino acids

HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection

Identification of new phase II metabolites of xanthohumol in rat in vivo biotransformation of hop extracts using high-performance liquid chromatography electrospray ionization tandem mass spectrometry.

Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin

Interaction of sanguinarine and its dihydroderivative with the Na+/K+-ATPase. Complex view on the old problem

Liquid chromatographic/electrospray mass spectrometric determination (LC/ESI-MS) of chelerythrine and dihydrochelerythrine in near-critical CO(2) extracts from real and spiked plasma samples.

Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study.

Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment.

Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.

Macleya cordata and Prunella vulgaris in oral hygiene products - their efficacy in the control of gingivitis

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.

Phytochemical and antimicrobial characterization of Macleaya cordata herb

Plasma lipoproteins in transport of silibinin, an antioxidant flavonolignan from Silybum marianum.

Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.

Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.

Silybin is metabolized by cytochrome P450 2C8 in vitro.

The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms

The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals?

The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat

The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial.

The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study