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List of works by Guy Brown

A 'top-down' approach to the determination of control coefficients in metabolic control theory

scientific article

Activated human neutrophils rapidly break down nitric oxide

scientific article published on 01 November 1997

Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis

scientific article published on 13 November 2015

Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration

scientific article

Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase

scientific article published on 4 June 2016

Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the 'top-down' approach of metabolic control theory

scientific article published on 01 March 1990

Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c.

scientific article

Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis

scientific article published on 15 June 2017

Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria

scientific article published on November 1996

Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria.

scientific article published in December 1995

Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia

scientific journal article

Cell biology. NO says yes to mitochondria

scientific article published on February 2003

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

scientific article

Changes in permeability to protons and other cations at high proton motive force in rat liver mitochondria

scientific article published on February 1986

Control analysis applied to single enzymes: can an isolated enzyme have a unique rate-limiting step?

scientific article

Control and kinetic analysis of ischemia-damaged heart mitochondria: which parts of the oxidative phosphorylation system are affected by ischemia?

article

Control of oxidative phosphorylation, gluconeogenesis, ureagenesis and ATP turnover in isolated perfused rat liver analyzed by top-down metabolic control analysis

scientific article published on 01 May 1998

Control of respiration and ATP synthesis in mammalian mitochondria and cells

scientific article

Control of respiration and oxidative phosphorylation in isolated rat liver cells

scientific article published on 01 September 1990

Cytochrome c and activation of caspases during myocardial ischaemia

scientific article published on 01 November 1998

Cytochrome oxidase content of rat brain during development

scientific article

Deciphering microglial diversity in Alzheimer's disease

scientific article published in June 2017

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia

scientific article published on 26 March 2014

Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine

scientific article

Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression

scientific article

Diffusion control of protein phosphorylation in signal transduction pathways

scientific article

Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'.

scientific article

Electrostatic coupling between membrane proteins

scientific article

Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study

scientific article published on 7 September 2006

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide

scientific article published on 31 July 2006

How microglia kill neurons

scientific article published on September 2015

In the eye of the storm: mitochondrial damage during heart and brain ischaemia

scientific article published on 18 June 2013

Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells

scientific article published on 30 October 2013

Inflammatory neurodegeneration and mechanisms of microglial killing of neurons

scientific article published on 02 March 2010

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

scientific article

Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

scientific article

Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo

scientific article published on 19 May 2014

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

scientific journal article

Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia

scientific article published in April 2003

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

scientific article published in July 2004

Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

scientific article published on November 2006

Introduction: Focus on mitochondria

scientific article

Kinetic analysis of changes in activity of heart mitochondrial oxidative phosphorylation system induced by ischemia

scientific article published on 01 October 1996

Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β.

scientific article published on 22 May 2013

Living too long: the current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy

scientific article published on 18 December 2014

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.

scientific article published on February 2012

Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

scientific article published on November 2007

Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase

scientific article published on January 2006

Microglial phagocytosis of live neurons

scientific article published on April 2014

Mitochondria in apoptosis of ischemic heart

scientific article

Mitochondria mediate nitric oxide-induced cell death

scientific article published on 01 January 1999

Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

scientific article published on 9 August 2007

Molecular Control Analysis: Control within Proteins and Molecular Processes

article

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

scientific article published on 01 December 1994

Near-infrared spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics

scientific article

Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system

scientific article published on November 2007

Neuroinflammation in Alzheimer's disease

scientific article (publication date: April 2015)

Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia

scientific article

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

scientific article published on 10 November 2017

Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release

scientific article

Nitric oxide and mitochondria

scientific article published on January 2007

Nitric oxide and mitochondrial respiration

scientific article

Nitric oxide and mitochondrial respiration in the heart

scientific article published on 3 April 2007

Nitric oxide and neuronal death

scientific article published on 12 June 2010

Nitric oxide and oxygen metabolism

scientific article published on August 1997

Nitric oxide as a competitive inhibitor of oxygen consumption in the mitochondrial respiratory chain

scientific article

Nitric oxide causes release of glutamate from brain synaptosomes

scientific article published in August 1997

Nitric oxide donors, nitrosothiols and mitochondrial respiration inhibitors induce caspase activation by different mechanisms

scientific article published in February 2000

Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition

scientific article published in April 2005

Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death

scientific article published in January 2005

Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase

scientific article

Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion

scientific article published on December 2003

Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes

scientific article published in December 2002

Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: implications for inflammatory, neurodegenerative and ischaemic pathologies

scientific article published on September 1, 1997

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

scientific article

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

scientific article published on 01 July 1995

Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release

scientific article

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase ⬇️

scientific article published on August 7, 1995

Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion

scientific article

Nitric oxide, cytochrome c and mitochondria

scientific article

Nitric oxide, hypoxia and brain inflammation

scientific article published in December 2004

Nitric oxide, mitochondria, and cell death

scientific article

Nitric oxide-dependent damage to neuronal mitochondria involves the NMDA receptor.

scientific article published in February 2002

Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways

scientific article

Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria.

scientific article

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

scientific article

Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?

scientific article published on March 1996

Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.

scientific article published on June 1998

Phagocytosis executes delayed neuronal death after focal brain ischemia

scientific article published on 07 October 2013

Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology

scientific article

Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration

scientific article published on 28 February 2012

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

scientific article published on 13 August 2012

Production of peroxynitrite from nitric oxide, hydrogen peroxide and superoxide dismutase: pathological implications

scientific article published on 01 August 1997

Proton/electron stoichiometry of mitochondrial complex I estimated from the equilibrium thermodynamic force ratio

scientific article published on June 1988

Quantification of information transfer via cellular signal transduction pathways ⬇️

scientific article published on September 8, 1997

Quantification of the relative contribution of parallel pathways to signal transfer: application to cellular energy transduction

scientific article published in October 1998

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

scientific article published on April 1996

Rate control within the Na+/glucose cotransporter

scientific article

Rate limitation within a single enzyme is directly related to enzyme intermediate levels

scientific article published on 01 July 1994

Regulation of apoptosis by the redox state of cytochrome c.

scientific article

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

scientific article

Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation.

scientific article

Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia

scientific article published on 01 September 2001

Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols

scientific article published on August 2000

Reversible binding and inhibition of catalase by nitric oxide

scientific article published on 01 August 1995

Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation

scientific article published in December 2001

Rotenone induces neuronal death by microglial phagocytosis of neurons

scientific article published on 10 July 2013

S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production

scientific article

S-nitrosothiol-induced rapid cytochrome c release, caspase activation and mitochondrial permeability transition in perfused heart

scientific article published in October 2003

Spatial gradients of cellular phospho-proteins

scientific article published in September 1999

Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production

scientific article published in January 2002

Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death

scientific article published on August 1999

Tetramethylphenylenediamine protects the isolated heart against ischaemia-induced apoptosis and reperfusion-induced necrosis

scientific article published on March 2011

The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide

scientific article published on 28 September 2009

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

scientific article published on 07 October 2008

The interactions between nitric oxide and brain nerve terminals as studied by electron paramagnetic resonance

scientific article published on 01 July 1995

The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems

scientific article published in October 2010

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

scientific article published on 15 February 2011

Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex

scientific article published on January 1985

Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex

scientific article published on January 1985

Thermodynamic limits to the stoichiometry of H+ pumping by mitochondrial cytochrome oxidase.

scientific article published in July 1985

Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria

scientific article published on February 1990

Total cell protein concentration as an evolutionary constraint on the metabolic control distribution in cells ⬇️

scientific article published on November 21, 1991

Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages

scientific article published on November 1998

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

scientific article published on 6 June 2014

Why do protein kinase cascades have more than one level?

scientific article published on 01 August 1997

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