List of works - Ana Vivancos

2399 Impact of KRAS mutations on clinical outcomes in advanced refractory pancreatic cancer patients

A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway

scientific article

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

scientific article

A personalized preclinical model to evaluate the metastatic potential of patient-derived colon cancer initiating cells

scientific article

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

scientific article

Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration

scientific article

Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation

scientific article published on 26 February 2018

Adapting a prescreening program to match molecular alterations in over 5,000 patients' tumors with targeted agents and immunotherapies in early clinical trials over the last 8 years

scientific article published on 01 September 2018

An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice

scientific article published on 7 December 2017

Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights

scientific article published on 15 June 2017

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

scientific article published on 28 March 2018

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

scientific article

Circulating cell-free DNA as predictor of treatment failure after neoadjuvant chemoradiotherapy before surgery in patients with locally advanced rectal cancer: is it ready for primetime?

scientific article published on 01 March 2018

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

scientific article published on 28 May 2013

Clinical and molecular characterization of refractory BRAF mutant metastatic colorectal carcinoma (mCRC): Vall d’Hebron Institute of Oncology phase I program cohort

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

scientific article

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors

scientific article published on 05 February 2020

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

scientific article published on 20 August 2018

Comparison of the Clinical Sensitivity of the Idylla Platform and the OncoBEAM RAS CRC Assay for KRAS Mutation Detection in Liquid Biopsy Samples

scientific article published on 20 June 2019

Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer

scientific article

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium

scientific article

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology

scientific article published on 09 March 2016

Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

scientific article published in October 2017

ERRATUM: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity

scientific article published on 11 February 2015

Early evolutionary divergence between papillary and anaplastic thyroid cancers.

scientific article

EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.

scientific article

Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas

scientific article published on 31 October 2019

Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials

scientific article published on 14 May 2020

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

scientific article published on 29 December 2017

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

scientific article

Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway.

scientific article published on 4 April 2016

Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity

scientific article

Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer

scientific article published on 08 March 2019

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

scientific article

ING proteins in cellular senescence.

scientific article published on May 2009

Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial

scientific article published on 20 September 2019

Identification of somatic gene mutations in penile squamous cell carcinoma.

scientific article published on 27 July 2015

Immune-Related Gene Expression Profiling After PD-1 Blockade in Non-Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma.

scientific article published on 9 May 2017

Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS-mutant metastatic colorectal cancer

scientific article published on 31 July 2019

Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review

scientific article

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway

scientific article published on 14 January 2010

Limitations in predicting PAM50 intrinsic subtype and risk of relapse score with Ki67 in estrogen receptor-positive HER2-negative breast cancer

scientific article

Long duration of immunotherapy in a STK11 mutated/KRAS wild-type non-small cell lung cancer patient

scientific article published on 07 August 2019

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

scientific article published on 13 August 2015

Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor

scientific article

Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid.

scientific article

Molecular prescreening to select patient population in early clinical trials

scientific article published on 03 April 2012

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer

scientific article published on 20 December 2020

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

scientific article

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

scientific article published on 21 September 2018

Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings

article

Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis

scientific article

New approach to cancer therapy based on a molecularly defined cancer classification.

scientific article

Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways.

scientific article published on 17 October 2006

Pancreatic cancer heterogeneity and response to Mek inhibition

scientific article published on 5 June 2017

Partial short-read sequencing of a highly inbred Iberian pig and genomics inference thereof

scientific article

Prognostic impact of KRAS mutation in metastatic (met) pancreatic cancer patients (pts)

Prospective multicenter real-world RAS mutation comparison between OncoBEAM-based liquid biopsy and tissue analysis in metastatic colorectal cancer

scientific article published on 23 November 2018

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.

scientific article published on 4 April 2018

Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis.

scientific article published on 22 January 2018

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

scientific article published on 15 November 2016

Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.

scientific article published in August 2003

Single-cell transcriptome conservation in cryopreserved cells and tissues

scientific article published on March 2017

Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.

scientific article published on 19 January 2016

Strand-specific deep sequencing of the transcriptome

scientific article

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

scientific article published on 06 August 2018

Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.

scientific article published on 29 July 2015

Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer

scientific article published on 19 September 2019

The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe

scientific article

The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

scientific article published on 4 April 2007

Transcription start site associated RNAs in bacteria.

scientific article published on 22 May 2012

List of works by Ana Vivancos

2399 Impact of KRAS mutations on clinical outcomes in advanced refractory pancreatic cancer patients

A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

A personalized preclinical model to evaluate the metastatic potential of patient-derived colon cancer initiating cells

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration

Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation

Adapting a prescreening program to match molecular alterations in over 5,000 patients' tumors with targeted agents and immunotherapies in early clinical trials over the last 8 years

An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice

Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

Circulating cell-free DNA as predictor of treatment failure after neoadjuvant chemoradiotherapy before surgery in patients with locally advanced rectal cancer: is it ready for primetime?

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

Clinical and molecular characterization of refractory BRAF mutant metastatic colorectal carcinoma (mCRC): Vall d’Hebron Institute of Oncology phase I program cohort

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

Comparison of the Clinical Sensitivity of the Idylla Platform and the OncoBEAM RAS CRC Assay for KRAS Mutation Detection in Liquid Biopsy Samples

Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer

Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium

Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology

Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

ERRATUM: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity

Early evolutionary divergence between papillary and anaplastic thyroid cancers.

EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.

Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas

Evolving Landscape of Molecular Prescreening Strategies for Oncology Early Clinical Trials

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway.

Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity

Genomic heterogeneity and efficacy of PI3K pathway inhibitors in patients with gynaecological cancer

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

ING proteins in cellular senescence.

Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial

Identification of somatic gene mutations in penile squamous cell carcinoma.

Immune-Related Gene Expression Profiling After PD-1 Blockade in Non-Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma.

Impact of circulating tumor DNA mutant allele fraction on prognosis in RAS-mutant metastatic colorectal cancer

Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review

Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway

Limitations in predicting PAM50 intrinsic subtype and risk of relapse score with Ki67 in estrogen receptor-positive HER2-negative breast cancer

Long duration of immunotherapy in a STK11 mutated/KRAS wild-type non-small cell lung cancer patient

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor

Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid.

Molecular prescreening to select patient population in early clinical trials

Molecular profiling of long-term responders to immune checkpoint inhibitors in advanced non-small cell lung cancer

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings

Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis

New approach to cancer therapy based on a molecularly defined cancer classification.

Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways.

Pancreatic cancer heterogeneity and response to Mek inhibition

Partial short-read sequencing of a highly inbred Iberian pig and genomics inference thereof

Prognostic impact of KRAS mutation in metastatic (met) pancreatic cancer patients (pts)

Prospective multicenter real-world RAS mutation comparison between OncoBEAM-based liquid biopsy and tissue analysis in metastatic colorectal cancer

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.

Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis.

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.

Single-cell transcriptome conservation in cryopreserved cells and tissues

Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.

Strand-specific deep sequencing of the transcriptome

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.

Targeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer

The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe

The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

Transcription start site associated RNAs in bacteria.