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List of works by Stuart A Rushworth

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

scientific article

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

scientific article published on 06 November 2018

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

scientific article published on 11 June 2013

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

scientific article published on June 15, 2012

CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma

scientific article published on 08 January 2019

Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction

scientific article published on 24 April 2019

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism ⬇️

scientific article published on September 1, 2010

Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection

scientific article published on 08 December 2021

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

scientific article published on 25 May 2017

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

scientific article published on 28 February 2018

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

scientific article published on January 6, 2011

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

scientific article published on 12 October 2017

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

scientific article

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

scientific article

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

scientific article published on 4 December 2013

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

scientific article published on 3 May 2017

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

scientific article

MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

scientific article published on 21 November 2016

Multiple amoebic liver abscesses ⬇️

scientific article published on May 12, 2011

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

scientific article

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

scientific article

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

scientific article

Oxidative stress responses and NRF2 in human leukaemia

scientific article

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

scientific article published on 20 July 2018

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

scientific article published on 10 March 2017

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

scientific article published on September 1, 2011

Pulling the plug - halting cancer's theft of mitochondria.

scientific article published on 2 November 2017

ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

scientific article published on 14 November 2019

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

scientific article published on April 2011

TNF mediates the sustained activation of Nrf2 in human monocytes

scientific article published on 13 June 2011

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

scientific article

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

scientific article published on 11 May 2016

Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

scientific article published on 19 April 2018

Targeting the oncogenic role of miRNA in human cancer using naturally occurring compounds ⬇️

scientific article published on January 1, 2011

The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

scientific article

The bone marrow microenvironment - Home of the leukemic blasts

scientific article published on 12 March 2017

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

scientific article published on 17 October 2012

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

scientific article published on 29 March 2011

Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei

scientific article published on 18 August 2016

Trypanosoma brucei: Inhibition of cathepsin L is sufficient to kill bloodstream forms

scientific article published on 16 November 2019

Understanding life and death decisions in human leukaemias.

scientific article

Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013

Understanding the role of miRNA in regulating NF-κB in blood cancer ⬇️

scientific article published on November 21, 2011

p16INK4A dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

scientific article published on 27 May 2022

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