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List of works by Kenji Ohgane

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

scientific article published on 13 March 2020

Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.

scientific article

Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

scientific article published on 12 January 2018

Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton

scientific article published on 27 August 2012

Discovery of Small Molecules that Induce the Degradation of Huntingtin

scientific article

Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site

scientific article published on 01 March 2013

Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

scientific article published on 14 December 2020

Multiplexing fluorogenic esterase-based viability assay with luciferase assays

scientific article published on 12 September 2019

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.

scientific article published on 22 April 2017

Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels-Alder Reactions

scientific article published in 2017

Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.

scientific article published on 17 June 2013

Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton

scientific article published on 26 March 2019

Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout.

scientific article

Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein

scientific article published on 02 June 2014

[Structural development study of a novel pharmacological chaperone for folding-defective rhodopsin mutants responsible for retinitis pigmentosa]

scientific article published on 01 March 2011

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