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List of works by Michael Howell

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

scientific article published on 03 September 2019

A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest ⬇️

scientific article published on 01 April 2019

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

scientific article published on 9 January 2017

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

scientific article published on 24 July 2017

Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study

scientific article published on 27 October 2021

Affordable luciferase reporter assay for cell-based high-throughput screening.

scientific article

Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid.

scientific article published on 9 May 2011

Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study

scientific article published in 2022

Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.

scientific article published on 2 May 2012

Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability

scientific article

Chromosomal instability confers intrinsic multidrug resistance.

scientific article

Chromosomal instability determines taxane response

scholarly article

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.

scientific article

Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication

scientific article

Defining host-pathogen interactions employing an artificial intelligence workflow

scientific article published on 12 February 2019

Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion

scientific article published on 25 September 2014

Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.

scientific article

HTS-DB: an online resource to publish and query data from functional genomics high-throughput siRNA screening projects

scientific article

High-throughput screening approaches to identify regulators of mammalian autophagy.

scientific article published on 14 February 2015

Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen

scientific article published on 01 January 2019

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

scientific article

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

scientific article published on 6 January 2016

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma

scientific article published on 14 February 2019

Manipulating signal delivery - plasma-membrane ERK activation in aPKC-dependent migration.

scientific article published on 20 July 2010

Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance

scientific article published on 21 March 2022

Multiomic Analysis of the UV-Induced DNA Damage Response ⬇️

scientific article

PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.

scientific article

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export.

scientific article published on 18 June 2018

Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

scientific article

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

scientific article published on 14 April 2020

Tales from an academic RNAi screening facility; FAQs.

scientific article published on 28 April 2011

The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery

scientific article published on 01 November 2018

The centriolar satellite protein Cep131 is important for genome stability

scientific article

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

scientific article published on 05 June 2018

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.

scientific article

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

scientific article published on 19 April 2022

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene

scientific article published on 16 February 2017

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases

scientific article published on 18 April 2019

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