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List of works by Shinne-Ren Lin

1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one as a new potent apoptosis agent

scientific article published on 25 September 2009

2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents

scientific article

A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells.

scientific article

Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells

scientific article

Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells ⬇️

scientific article published on October 31, 2011

Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells

scientific article published on 21 May 2013

Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells

scientific article published on 17 August 2015

Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway

scientific article

Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells.

scientific article

Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway ⬇️

scientific article published on June 7, 2012

Cardiotoxin III suppresses hepatocyte growth factor-stimulated migration and invasion of MDA-MB-231 cells

scientific article

Cardiotoxin III-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation in K562 cells

scientific article published on 01 May 2008

Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization

scientific article

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells

scientific article

Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells

scientific article published on 23 May 2013

Design, syntheses, and biological evaluations of squamostolide and its related analogs

scientific article published on October 2005

Differential binding to phospholipid bilayers modulates membrane-damaging activity of Naja naja atra cardiotoxins

scientific article published on 18 May 2009

Disulfide isomerization and thiol-disulfide exchange of long neurotoxins from the venom of Ophiophagus hannah

scientific article published on 23 August 2006

Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells

scientific article

Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells

scientific article published on January 2009

Effects of cardiotoxin III on expression of genes and proteins related to G2/M arrest and apoptosis in K562 cells.

scientific article published on 6 December 2006

Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins

scientific article

Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells

scientific article

Guanidination of notexin alters its membrane-damaging activity in response to sphingomyelin and cholesterol ⬇️

scientific article published on December 1, 2010

Guanidination of notexin promotes its phospholipase A2 activity-independent fusogenicity on vesicles with lipid-supplied negative curvature ⬇️

scientific article published on October 23, 2011

Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra

scientific article published in October 2009

Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells.

scientific article

Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells

scientific article published on 19 September 2006

Induction of G2/M phase arrest by squamocin in chronic myeloid leukemia (K562) cells

scientific article published on 28 November 2005

Induction of apoptosis in human leukemia K562 cells by cardiotoxin III

scientific article published on 27 January 2005

Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells

scientific article

Inhibition of Src activation with cardiotoxin III blocks migration and invasion of MDA-MB-231 cells

scientific article published on 7 August 2013

Inhibitory action of naphtho[1,2-b]furan-4,5-dione on hepatocyte growth factor-induced migration and invasion of MDA-MB-231 cells: mechanisms of action

scientific article

Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity

scientific article published on March 2010

Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells

scientific article published on 25 May 2008

Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells

scientific article published on 29 March 2007

Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.

scientific article published on 25 January 2007

Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells

scientific article

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells

scientific article published on 13 October 2007

Lipid domain formation modulates activities of snake venom phospholipase A(2) enzymes

scientific article published on 10 August 2010

Mechanisms of cardiotoxin lll-induced apoptosis in human colorectal cancer colo205 cells

scientific article published on March 2006

Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity

scientific article published on 7 May 2011

Membrane-damaging activity with A chain and B chain of beta-bungarotoxin

scientific article

Modification of substrate inhibition of synaptosomal acetylcholinesterase by cardiotoxins

scientific article published in May 2004

Modulated mechanism of phosphatidylserine on the catalytic activity of Naja naja atra phospholipase A2 and Notechis scutatus scutatus notexin

scientific article published on 17 October 2014

Mutations on N-terminal region of Taiwan cobra phospholipase A(2) result in structurally distorted effects

scientific article

Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes ⬇️

scientific article published on May 5, 2012

Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells

scientific article

Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells

scientific article

Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation

scientific article

Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway

scientific article published on 2 April 2010

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways

scientific article published on 26 October 2013

Novel acyclic enediynes inhibit Cyclin A and Cdc25C expression and induce apoptosis phenomenon to show potent antitumor proliferation

scientific article published on 19 April 2007

Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation

scientific article

Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells

scientific article

Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells

scientific article published on 28 June 2008

Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles ⬇️

scientific article published on August 30, 2011

Phospholipase A2 activity-independent membrane-damaging effect of notexin

scientific article published in August 2007

Purification and characterization of Ophiophagus hannah cytotoxin-like proteins

scientific article published on 29 June 2006

Purification and characterization of Taiwan cobra venom proteins with weak toxicity

scientific article published on 01 January 2005

Purification and characterization of a neurotoxin from the venom of Ophiophagus hannah (king cobra).

scientific article

Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2 ⬇️

scientific article published on June 1, 2012

Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression

scientific article published on 12 February 2015

Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles

scientific article published on 6 August 2009

Separation and structure-function studies of Taiwan cobra cardiotoxins

scientific article

Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives

scientific article published on 18 January 2006

Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives

scientific article published on 10 June 2010

Synthesis and biological evaluation of novel symmetry bis-enediynes

scientific article

Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells

scientific article

Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells

scientific article published on 13 January 2016

Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization

scientific article published on 4 December 2007

Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells

scientific article

Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells

scientific article published on 27 May 2014

The mechanism of cytotoxicity by Naja naja atra cardiotoxin 3 is physically distant from its membrane-damaging effect

scientific article published on 27 June 2007

The structural and functional contribution of N-terminal region and His-47 on Taiwan cobra phospholipase A2.

scientific article published in March 2008

Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells

scientific article published on 01 August 2006

Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation

scientific article

p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells

scientific article published on 9 July 2008

p38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells

scientific article published on 29 March 2010

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