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List of works by Jason Moffat

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells

scientific article published on 06 November 2019

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

scientific journal article

A genome scale overexpression screen to reveal drug activity in human cells

scientific article

A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.

scientific article

A method for benchmarking genetic screens reveals a predominant mitochondrial bias

scientific article published on 01 May 2021

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

scientific article published on 08 October 2013

A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

scientific article published on December 2013

A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations ⬇️

scientific article published in Scientific Reports

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

scientific article published on 25 September 2018

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

scientific article

A versatile lentiviral expression system to identify mammalian protein-protein interactions.

scientific article published on 17 June 2012

Affinity Selection from Peptide Libraries to Determine Substrate Specificity of Protein Tyrosine Phosphatases ⬇️

scientific article published on April 10, 1998

Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline

scientific article published on 10 September 2021

Automated inference procedure for the determination of cell growth parameters.

scientific article published on 7 January 2016

BAGEL: a computational framework for identifying essential genes from pooled library screens.

scientific article

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells

scientific article published on 21 May 2019

CD133 Protein N-Glycosylation Processing Contributes to Cell Surface Recognition of the Primitive Cell Marker AC133 Epitope ⬇️

scientific article published on September 21, 2011

CD133-targeted niche-dependent therapy in cancer: a multipronged approach

scientific article published on 28 February 2014

COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines ⬇️

scientific article published on November 18, 2011

CRISPR screens are feasible in TP53 wild-type cells

scientific article published on 01 August 2019

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

scientific article published in Nature

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

scientific article published on 15 April 2015

Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B ⬇️

scientific article published on September 1, 2011

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

scientific article published in November 2017

Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma

scientific article published on 26 June 2018

Cyclin Partners Determine Pho85 Protein Kinase Substrate Specificity In Vitro and In Vivo: Control of Glycogen Biosynthesis by Pcl8 and Pcl10 ⬇️

scientific article published on June 1, 1998

Cytokinetic effects of Wee1 disruption in pancreatic cancer.

scientific article published on 18 February 2016

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

scientific article

Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells

scientific article

Developmentally programmed nuclear destruction during yeast gametogenesis.

scientific article

Differential regulation of FGFR3 by PTPN1 and PTPN2.

scientific article published on 17 December 2014

Digital microfluidic isolation of single cells for -Omics

scientific article published on 11 November 2020

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF

scientific article published on 01 January 2019

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

scientific article

Emerging and evolving concepts in gene essentiality.

scientific article published on 16 October 2017

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies

scientific article published on 01 April 2019

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

scientific article

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

scientific article

Extensive mapping of an innate immune network with CRISPR.

scientific article published on 24 July 2015

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion

scientific article published on 30 September 2019

Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response

scientific article published on 06 December 2018

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

scientific article published on 23 September 2020

Functional genomics identifies new synergistic therapies for retinoblastoma

scientific article published on 22 June 2020

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

scientific article

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform

scientific article published on 16 March 2020

Genetic interaction networks in cancer cells

scientific article published on 01 February 2019

Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons

scientific article published on 01 November 2018

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

scientific article

Global Genetic Networks and the Genotype-to-Phenotype Relationship

scientific article published on 01 March 2019

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

scientific article published on 25 November 2015

High-content CRISPR screening

scientific article published in 2022

High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting

scientific article published on 23 September 2019

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

scientific article published on 23 February 2018

INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

scientific article published on June 2015

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers

scientific article published on 01 February 2020

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

scientific article published on 21 August 2015

Identification of RNF168 as a PML nuclear body regulator

scientific article published on 16 December 2015

Identifying chemogenetic interactions from CRISPR screens with drugZ

scientific article published on 22 August 2019

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

scientific article

Inhibition of SREBP1 sensitizes cells to death ligands.

scientific article

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

scientific article published on June 2015

Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma.

scientific article published on August 2013

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching

scientific article published on 17 November 2016

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.

scientific article published on 05 June 2013

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

scientific article published on 11 June 2018

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

scientific article

Miniature short hairpin RNA screens to characterize antiproliferative drugs

scientific article

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

scientific article published in February 2017

Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes

article

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

scientific article published in 2021

Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients ⬇️

scientific article published on 01 February 1998

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

scientific article published on 04 September 2019

Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells

scientific article published on 01 January 2019

Pooled lentiviral shRNA screening for functional genomics in mammalian cells.

scientific article

Pooled screening for antiproliferative inhibitors of protein-protein interactions.

scientific article

Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation

scientific article

Protocadherin-1 is essential for cell entry by New World hantaviruses

scientific article published in Nature

RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR.

scientific article published on 29 March 2015

RNA interference screens to uncover membrane protein biology.

scientific article

RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

scientific article published in August 2017

Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins.

scientific article published on 15 April 2013

SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress

scientific article published on 6 February 2017

Scaling up the systematic hunt for mammalian genetic interactions ⬇️

scientific article published on 01 May 2013

Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display

scientific article published in September 2015

SnapShot: High-throughput sequencing applications

scientific article published on 01 September 2011

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

scientific article published on 31 January 2019

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies

scientific article published on 20 March 2019

Suppression of cancer progression by MGAT1 shRNA knockdown.

scientific article

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

scientific article

System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.

scientific article

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

scientific article published on 01 June 2020

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

scientific article published on 27 August 2019

Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles.

scientific article

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.

scientific article published on 04 May 2016

The inhibitory NKR-P1B:Clr-b recognition axis facilitates detection of oncogenic transformation and cancer immunosurveillance.

scientific article

The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription

scientific article published on 14 February 2012

The shieldin complex mediates 53BP1-dependent DNA repair

scientific article published in Nature

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.

scientific article published on June 2015

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases

scientific article published on 11 February 2019

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

scientific article published on 31 January 2014

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