List of works by Atanasio Pandiella

A Transcriptomic Immunologic Signature Predicts Favorable Outcome in Neoadjuvant Chemotherapy Treated Triple Negative Breast Tumors

scientific article published on 18 December 2019

A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers.

scientific article

A modular approach to trim cellular targets in anticancer drug discovery

scientific article published on 22 September 2011

A new method for detecting TNF-alpha-secreting cells using direct-immunofluorescence surface membrane stainings

scientific article published in June 2002

A new simple whole blood flow cytometry-based method for simultaneous identification of activated cells and quantitative evaluation of cytokines released during activation.

scientific article

A phase I study of the SRC kinase inhibitor dasatinib with trastuzumab and paclitaxel as first line therapy for patients with HER2-overexpressing advanced breast cancer. GEICAM/2010-04 study

scientific article published on 14 April 2017

Achilles' heel of triple negative cancer

scientific article

Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin

scientific article

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

scientific article

Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

scientific article

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

scientific article published on 30 August 2019

Adaptive resistance to trastuzumab impairs response to neratinib and lapatinib through deregulation of cell death mechanisms

scientific article published on 22 November 2019

Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine

scientific article published on 27 October 2020

An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy

scientific article published on 25 August 2020

An update into the pathophysiological role of HER2 in cancer: therapeutic implications

scientific article published on 01 September 2007

Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands

scientific article

Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment

scientific article published on 21 August 2020

Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester

scientific article published on 27 July 2016

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

scientific article

Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies

scientific article published on 01 August 1993

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

scientific article published on 30 September 2015

Antitumoral effect of Ocoxin in hepatocellular carcinoma.

scientific article published on 21 June 2017

Antitumoral effect of Ocoxin on acute myeloid leukemia.

scientific article published on 9 January 2016

Antitumoral effect of Ocoxin, a natural compound-containing nutritional supplement, in small cell lung cancer.

scientific article published on 16 April 2018

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

scientific article

Autocrine regulation of membrane transforming growth factor-alpha cleavage

scientific article published on 01 February 1996

Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis

scientific article published on 27 July 2010

BET inhibitors as novel therapeutic agents in breast cancer.

scientific article published on August 2017

Biological insights into effective and antagonistic combinations of targeted agents with chemotherapy in solid tumors

scientific article published on March 2014

Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines

scientific article

Bortezomib is an efficient agent in plasma cell leukemias

scientific article

Breast Cancer Heterogeneity and Response to Novel Therapeutics

scientific article published on 05 November 2020

Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.

scientific article

Bryonia dioica aqueous extract induces apoptosis and G2/M cell cycle arrest in MDA‑MB 231 breast cancer cells

scientific article published on 09 May 2019

CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

scientific article published on 7 February 2012

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

scientific article

Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue.

scientific article published on June 2013

Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin

scientific article published on 14 May 2019

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer

scientific article published on 27 November 2020

Circulating DNA and Survival in Solid Tumors

scientific article

Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signalling-competent truncated forms

scientific article published on 01 April 1999

Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients

scientific article published on 15 February 2012

Colorectal cancer and medicinal plants: Principle findings from recent studies

scientific article published on 09 August 2018

Correction: CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

article

DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer

scientific article published on 28 July 2016

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects

scientific article (publication date: 2012)

Defective cyclin B1 induction in trastuzumab-emtansine (T-DM1) acquired resistance in HER2-positive breast cancer.

scientific article published on 18 August 2017

Deficient spindle assembly checkpoint in multiple myeloma

scientific article

Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme

scientific article published on 01 November 2000

Do we have to change the way targeted drugs are developed?

scientific article published on 21 June 2010

Dual targeting of HER2-positive breast cancer with trastuzumab emtansine and pertuzumab: understanding clinical trial results

scientific article published on 07 August 2018

ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy

scientific article

ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo.

scientific article published on December 2006

ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.

scientific article published on June 2013

Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer

scientific article published on 4 August 2015

Effect of multikinase inhibitors on caspase-independent cell death and DNA damage in HER2-overexpressing breast cancer cells

scientific article published on September 2010

Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

scientific article

Efficacy and safety of dasatinib with trastuzumab and paclitaxel in first line HER2-positive metastatic breast cancer: results from the phase II GEICAM/2010-04 study

scientific article published on 03 January 2019

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

scientific article published on January 2004

Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation

scientific article published on 15 August 2006

Enhancement of antiproliferative activity by molecular simplification of catalpol

scientific article published on March 2010

Epigenetic modulation of FOXM1-gene interacting network by BET inhibitors in breast cancer

scientific article published on 11 September 2018

Erk5 is activated and acts as a survival factor in mitosis.

scientific article

Erk5 nuclear location is independent on dual phosphorylation, and favours resistance to TRAIL-induced apoptosis

scientific article published on 25 January 2007

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

scientific article

Erratum: Achilles' heel of triple negative cancer

scientific article published on 13 December 2014

Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

scientific article published in PLoS ONE

Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target

scientific article published on 15 May 2009

Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome

scientific article published on 03 July 2019

Expression of c-Kit isoforms in multiple myeloma: differences in signaling and drug sensitivity.

scientific article

Expression of the beta-isoforms of Na,K-ATPase in the renal cortex of rats

scientific article published on 01 January 1997

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

scientific article

Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.

scientific article published on 25 March 2018

Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

scientific article published on 01 May 2005

Genetic and pharmacologic evidence that mTOR targeting outweighs mTORC1 inhibition as an antimyeloma strategy

scientific article published on 15 January 2014

Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors

article

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1

scientific article published on 11 August 2020

Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors

scientific article published on 01 January 2019

HER2 heterogeneity and resistance to anti-HER2 antibody-drug conjugates

scientific article published on 31 January 2020

HER3 overexpression and survival in solid tumors: a meta-analysis

scientific article published on 8 December 2012

HER3 targeting with an antibody-drug conjugate bypasses resistance to anti-HER2 therapies

scientific article published on 24 April 2020

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

scientific article published on 13 August 2015

Identifying breast cancer druggable oncogenic alterations: lessons learned and future targeted options.

scientific article published on February 2008

Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents

scientific article published on December 2003

Impact of Availability of Companion Diagnostics on the Clinical Development of Anticancer Drugs

scientific article published on 28 February 2017

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

scientific article published on 24 April 2003

In Silico Analysis Guides Selection of BET Inhibitors for Triple-Negative Breast Cancer Treatment.

scientific article

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases.

scientific article published on 16 March 2016

In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

scientific article

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.

scientific article

Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

scientific article published on 9 June 2010

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

scientific article

Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.

scientific article published on 13 June 2011

Inhibition of the mitotic kinase PLK1 overcomes therapeutic resistance to BET inhibitors in triple negative breast cancer

scientific article published on 28 July 2020

Integrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis

scientific article published on 01 April 2020

Interaction between Hormonal Receptor Status, Age and Survival in Patients with BRCA1/2 Germline Mutations: A Systematic Review and Meta-Regression

scientific article

MEK5 promotes lung adenocarcinoma

scientific article published on 28 February 2019

Mapping Bromodomains in breast cancer and association with clinical outcome

scientific article published on 05 April 2019

Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin.

scientific article

Medicinal Plants as Sources of Active Molecules Against COVID-19

scientific article published on 07 August 2020

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

scientific article published on 09 April 2009

Mitogen-activated protein kinase routes as targets in the action of diaza-anthracene compounds with a potent growth-inhibitory effect on cancer cells

scientific article

Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.

scientific article published on April 2002

Mitotic arrest induced by a novel family of DNA topoisomerase II inhibitors.

scientific article

Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors.

scientific article published on March 2017

Modulation of cereblon levels by anti-myeloma agents.

scientific article

Molecular pathways: P-Rex in cancer.

scientific article published on 10 June 2013

Multifunctional role of Erk5 in multiple myeloma

scientific article published on 3 February 2005

Multisite phosphorylation of Erk5 in mitosis

scientific article published on 24 August 2010

Multisite phosphorylation of P-Rex1 by protein kinase C.

scientific article published on 24 October 2016

N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity.

scientific article published on July 2005

NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.

scientific article published on 15 May 2014

Neuregulin expression in solid tumors: prognostic value and predictive role to anti-HER3 therapies

scientific article published on 08 April 2016

Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer

scientific article published on 01 July 2007

Neuregulins and cancer.

scientific article published on June 2008

Neutrophils in cancer: prognostic role and therapeutic strategies.

scientific article published on 15 August 2017

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

scientific article published on December 2008

Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development

scientific article

Novel tyrosine kinase inhibitors in the treatment of cancer.

scientific article

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.

scientific article published on 19 September 2016

Oncogenic targets, magnitude of benefit, and market pricing of antineoplastic drugs

scientific article published on 23 May 2011

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

scientific article

Overexpression of RasN17 fails to neutralize endogenous Ras in MCF7 breast cancer cells

scientific article published on June 2005

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

scientific article

PDCD4 limits prooncogenic neuregulin-ErbB signaling

scientific article published on 17 August 2020

Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors

scientific article published on 29 June 2019

Pemetrexed acts as an antimyeloma agent by provoking cell cycle blockade and apoptosis.

scientific article published on 22 February 2007

Personalized therapies in the cancer "omics" era

scientific article published on 29 July 2010

Pharmacological screening and transcriptomic functional analyses identify a synergistic interaction between dasatinib and olaparib in triple-negative breast cancer

scientific article published on 07 February 2020

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

scientific article published on 22 September 2015

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling.

scientific article

Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.

scientific article published on 27 July 2013

Potent antimyeloma activity of a novel ERK5/CDK inhibitor

scientific article published on 26 March 2013

Preclinical development of molecular-targeted agents for cancer

scientific article published on 07 December 2010

Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications.

scientific article

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

scientific article published on 15 October 2019

Prognostic relevance of receptor tyrosine kinase expression in breast cancer: a meta-analysis.

scientific article published on 3 September 2014

Prognostic value of receptor tyrosine kinase-like orphan receptor (ROR) family in cancer: A meta-analysis

scientific article published on 29 May 2019

Proteolysis targeting chimeras (PROTACs) in cancer therapy

scientific article published on 15 September 2020

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

scientific article published on 7 July 2012

Refining Early Antitumoral Drug Development

article

Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.

scientific article published on 15 October 2017

Resistance to Antibody-Drug Conjugates.

scientific article

Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

scientific article published on 7 July 2017

Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes

scientific article published on January 2006

Screening and Preliminary Biochemical and Biological Studies of [RuCl(p-cymene)(N,N-bis(diphenylphosphino)-isopropylamine)][BF4] in Breast Cancer Models

scientific article published on 01 August 2019

Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells.

scientific article published on 17 July 2008

Synthetic lethality interaction between Aurora kinases and CHEK1 inhibitors in ovarian cancer.

scientific article published on 28 August 2017

TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

scientific article published on 5 July 2006

TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells

scientific article published on 27 March 2019

Targeting HER receptors in cancer

scientific article published on January 2013

Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors

scientific article published on 3 January 2017

Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

scientific article

Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer

scientific article published on 27 July 2006

Targeting the EGF/HER Ligand-Receptor System in Cancer.

scientific article

The Activation of the Sox2 RR2 Pluripotency Transcriptional Reporter in Human Breast Cancer Cell Lines is Dynamic and Labels Cells with Higher Tumorigenic Potential

scientific article

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

scientific article published on January 2008

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

scientific article published on 05 July 2012

The evolving landscape of protein kinases in breast cancer: clinical implications.

scientific article published on 15 June 2012

The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function.

scientific article published on 15 November 2006

The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

scientific article published on June 2006

The immunoglobulin-like domain of neuregulins potentiates ErbB3/HER3 activation and cellular proliferation.

scientific article published on 14 May 2018

The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.

scientific article published on 12 March 2008

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

scientific article published on 2 September 2014

The mitogen-activated protein kinase Erk5 mediates human mesangial cell activation.

scientific article published on 21 June 2008

Therapeutic potential of ERK5 targeting in triple negative breast cancer

scientific article

Transautocrine signaling by membrane neuregulins requires cell surface targeting, which is controlled by multiple domains

scientific article

Transcriptome evolution from breast epithelial cells to basal-like tumors.

scientific article published on 8 December 2017

Transcriptomic analyses identify association between mitotic kinases, PDZ-binding kinase and BUB1, and clinical outcome in breast cancer

scientific article published on 20 February 2016

Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors

scientific article

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

scientific article published on September 2014

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

scientific article

Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts

scientific article published on 01 February 2002

Trastuzumab Emtansine: Mechanisms of Action and Resistance, Clinical Progress, and Beyond

scientific article published on 21 January 2020

Trastuzumab and antiestrogen therapy: focus on mechanisms of action and resistance.

scientific article published in February 2006

Tumor-infiltrating lymphocytes in breast cancer: ready for prime time?

scientific article published on 9 March 2015

Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.

scientific article published on 13 December 2017

What about incorporating selenium in the therapeutic regimen of SARS-CoV-2?

scientific article published on 07 December 2020

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.

scientific article published on 17 February 2011

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.

scientific article

β-Lapachone analogs with enhanced antiproliferative activity

scientific article published on 19 April 2012

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